Histatins are proteins found in saliva. They are antimicrobial and antifungal proteins, and have been found to play a role in wound-closure.A significant source of histatins are found in the serous fluid secreted by Von Ebner's glands, salivary glands at the back of the tongue. Here they offer some early defense against incoming microbes.
The 3 major histatins are 1,3, and 5. Histatin 2 is a degradation product of histatin 1, and all other histatins are degradation products of histatin 3. Therefore there are only two genes, HTN1 and HTN3.