Histidine ammonia-lyase

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Histidine ammonia-lyase
Identifiers
Symbols HAL ; HIS; HSTD
External IDs OMIM609457 MGI96010 HomoloGene68229 ChEMBL: 4003 GeneCards: HAL Gene
EC number 4.3.1.3
Orthologs
Species Human Mouse
Entrez 3034 15109
Ensembl ENSG00000084110 ENSMUSG00000020017
UniProt P42357 P35492
RefSeq (mRNA) NM_001258333 NM_010401
RefSeq (protein) NP_001245262 NP_034531
Location (UCSC) Chr 12:
96.37 – 96.39 Mb
Chr 10:
93.49 – 93.52 Mb
PubMed search [1] [2]
histidine ammonia-lyase
Identifiers
EC number 4.3.1.3
CAS number 9013-75-6
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

Histidine ammonia-lyase (or histidase, or histidinase) is an enzyme that in humans is encoded by the HAL gene.[1][2] Histidase converts histidine into ammonia and urocanic acid.

Function[edit]

Histidine ammonia-lyase is a cytosolic enzyme catalyzing the first reaction in histidine catabolism, the nonoxidative deamination of L-histidine to trans-urocanic acid.[1]

Pathology[edit]

Mutations in the gene for histidase are associated with histidinemia and urocanic aciduria.

Further reading[edit]

References[edit]

  1. ^ a b "Entrez Gene: histidine ammonia-lyase". 
  2. ^ Suchi M, Sano H, Mizuno H, Wada Y (September 1995). "Molecular cloning and structural characterization of the human histidase gene (HAL)". Genomics 29 (1): 98–104. doi:10.1006/geno.1995.1219. PMID 8530107. 

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.