History of lysergic acid diethylamide
The psychedelic drug/entheogen LSD was first synthesized by the Swiss chemist Albert Hofmann in the Sandoz (now Novartis) laboratories in Basel, Switzerland on November 16, 1938. It was not until five years later on April 16, 1943, that the psychedelic properties were found.
- 1 Discovery
- 2 Psychiatric use
- 3 Resistance and prohibition
- 4 Influential individuals
- 5 Secret government experiments
- 6 Recreational use
- 7 References
- 8 External links
Albert Hofmann, born in Baden, Switzerland, joined the pharmaceutical-chemical department of Sandoz Laboratories, located in Basel as a co-worker with professor Arthur Stoll, founder and director of the pharmaceutical department. He began studying the medicinal plant squill and the fungus ergot as part of a program to purify and synthesize active constituents for use as pharmaceuticals. His main contribution was to elucidate the chemical structure of the common nucleus of Scilla glycosides (an active principle of Mediterranean Squill). While researching lysergic acid derivatives, Hofmann first synthesized LSD on November 16, 1938. The main intention of the synthesis was to obtain a respiratory and circulatory stimulant (an analeptic). It was set aside for five years, until April 16, 1943, when Hofmann decided to take a second look at it. While re-synthesizing LSD, he accidentally absorbed a small amount of the drug through his fingertips and discovered its powerful effects. He described what he felt as being:
... affected by a remarkable restlessness, combined with a slight dizziness. At home I lay down and sank into a not unpleasant intoxicated-like condition, characterized by an extremely stimulated imagination. In a dreamlike state, with eyes closed (I found the daylight to be unpleasantly glaring), I perceived an uninterrupted stream of fantastic pictures, extraordinary shapes with intense, kaleidoscopic play of colors. some two hours this condition faded away.
April 19, 1943, Hofmann performed a self-experiment to determine the true effects of LSD, intentionally ingesting 0.25 milligrams (250 micrograms) of the substance, an amount he predicted to be a threshold dose (an actual threshold dose is 20 micrograms). Less than an hour later, Hofmann experienced sudden and intense changes in perception. He asked his laboratory assistant to escort him home and, as use of motor vehicles was prohibited because of wartime restrictions, they had to make the journey on a bicycle. On the way, Hofmann’s condition rapidly deteriorated as he struggled with feelings of anxiety, alternating in his beliefs that the next-door neighbor was a malevolent witch, that he was going insane, and that the LSD had poisoned him. When the house doctor arrived, however, he could detect no physical abnormalities, save for a pair of incredibly dilated pupils. Hofmann was reassured, and soon his terror began to give way to a sense of good fortune and enjoyment, as he later wrote...
"... little by little I could begin to enjoy the unprecedented colors and plays of shapes that persisted behind my closed eyes. Kaleidoscopic, fantastic images surged in on me, alternating, variegated, opening and then closing themselves in circles and spirals, exploding in colored fountains, rearranging and hybridizing themselves in constant flux ..."
The events of the first LSD trip, now known as “Bicycle Day”, after the bicycle ride home, proved to Hofmann that he had indeed made a significant discovery: a psychoactive substance with extraordinary potency, capable of causing significant shifts of consciousness in incredibly low doses. Hofmann foresaw the drug as a powerful psychiatric tool; because of its intense and introspective nature, he couldn’t imagine anyone using it recreationally. Bicycle day is increasingly observed in psychedelic communities as a day to celebrate the discovery of LSD.
The celebration of Bicycle Day originated in DeKalb, IL., in 1985, when Thomas B. Roberts, then a Professor at Northern Illinois University, invented the name "Bicycle Day" when he founded the first Bicycle Day celebration at his home. Several years later, he sent an announcement made by one of his students  to friends and Internet lists, thus propagating the idea and the celebration. His original intent was to commemorate Hofmann's original, accidental exposure on April 16, but that date fell midweek and was not a good time for the party, so he chose the 19th to honor Hofmann's first intentional exposure.
LSD was brought to the attention of the United States in 1949 by Sandoz Laboratories because they believed LSD might have clinical applications.
Throughout the 1950s, mainstream media reported on research into LSD, undergraduate psychology students taking LSD as part of their education, described the effects of the drug, and its growing use in psychiatry. Time Magazine published 6 positive reports on LSD between 1954 and 1959.
LSD was originally perceived as a psychotomimetic capable of producing model psychosis. By the mid-1950s, LSD research was being conducted in major American medical centers, where researchers used LSD as a means of temporarily replicating the effects of mental illness. One of the leading authorities on LSD during the 1950s in the United States was the psychoanalyst Sidney Cohen. Cohen first took the drug on October 12, 1955 and expected to have an unpleasant trip, but was surprised when he experienced “no confused, disoriented delirium.” He reported that the “problems and strivings, the worries and frustrations of everyday life vanished; in their place was a majestic, sunlit, heavenly inner quietude.” Cohen immediately began his own experiments with LSD with the help of Aldous Huxley whom he had met in 1955. In 1957, with the help of Betty Eisner, Cohen began experimenting on whether or not LSD might have a helpful effect in facilitating psychotherapy, curing alcoholism, and enhancing creativity. Between 1957 and 1958, they treated twenty-two patients who suffered from minor personality disorders. LSD was also given to artists in order to track their mental deterioration, but Huxley believed LSD might enhance their creativity. Between 1958 and 1962, Oscar Janiger tested LSD on more than a hundred painters, writers, and composers.
In one study in the late 1950s, Dr Humphry Osmond gave LSD to alcoholics in Alcoholics Anonymous who had failed to quit drinking. After one year, around 50% of the study group had not had a drink — a success rate that has never been duplicated by any other means.
In the United Kingdom the use of LSD was pioneered by Dr Ronald A. Sandison in 1952, at Powick Hospital, Worcestershire. A special LSD unit was set up in 1958. After Dr Sandison left the hospital in 1964, medical superintendent Dr Justin Johanson took over and used the drug until he retired in 1972. In all, 683 patients were treated with LSD in 13,785 separate sessions at Powick, but Dr Spencer was the last member of the medical staff to use it.
From the late 1940s through the mid-1970s, extensive research and testing was conducted on LSD. During a 15-year period beginning in 1950, research on LSD and other hallucinogens generated over 1000 scientific papers, several dozen books, and 6 international conferences, and LSD was prescribed as treatment to over 40,000 patients. Film star Cary Grant was one of many men during the 1950s and 1960s who were given LSD in concert with psychotherapy. Many psychiatrists began taking the drug recreationally and sharing it with friends. Dr. Leary's experiments (see Timothy Leary below) spread LSD usage to a much wider segment of the general populace.
Sandoz halted LSD production in August 1965 after growing governmental protests at its proliferation among the general populace. The National Institute of Mental Health in the United States distributed LSD on a limited basis for scientific research. Scientific study of LSD largely ceased by about 1980 as research funding declined, and governments became wary of permitting such research, fearing that the results of the research might encourage illicit LSD use. By the end of the 20th century, there were few authorized researchers left, and their efforts were mostly directed towards establishing approved protocols for further work with LSD in easing the suffering of the dying (See thanatotherapy) and with drug addicts and alcoholics.
Sandoz began to hypothesize he could use LSD as a way to treat optic nerve hypoplasia, a congenital medical condition where the optic disc appears abnormally small. To test this new hypothesis, Sutcliffe began his testing on lab mice by making them ingest controlled amounts of LSD then dissecting them after to observe the results. He found an inconsistency in his results in which only 70% of the mice had blood engorged frontal lobes, which he narrowed down to previous history of high blood pressure and stress related problems. No other physical uses have been proposed or tested.
Resistance and prohibition
By the mid-sixties the backlash against the use of LSD and its perceived corrosive effects on the values of the Western middle class resulted in governmental action to restrict the availability of the drug by making any use of it illegal. Despite a history of positive results of judicious use under controlled circumstances, LSD was declared a "Schedule 1", entailing that the drug has a "high potential for abuse" and is without any "currently accepted medical use in treatment". LSD was removed from legal circulation. To support this action, the United States Drug Enforcement Administration claimed:
Although initial observations on the benefits of LSD were highly optimistic, empirical data developed subsequently proved less promising ... Its use in scientific research has been extensive and its use has been widespread. Although the study of LSD and other hallucinogens increased the awareness of how chemicals could affect the mind, its use in psychotherapy largely has been debunked. It produces no aphrodisiac effects, does not increase creativity, has no lasting positive effect in treating alcoholics or criminals, does not produce a 'model psychosis', and does not generate immediate personality change.However, drug studies have confirmed that the powerful hallucinogenic effects of this drug can produce profound adverse reactions, such as acute panic reactions, psychotic crises, and "flashbacks", especially in users ill-equipped to deal with such trauma.
LSD became illegal in California on October 6, 1966. Other U.S. states and the rest of the world followed with the ban.
Renowned British intellectual Aldous Huxley was one of the most important figures in the early history of LSD. He was a figure of high repute in the world of letters and had become internationally famous through his novels Crome Yellow, Antic Hay and his dystopian novel Brave New World. His experiments with psychedelic drugs (initially mescaline) and his descriptions of them in his writings did much to spread awareness of psychedelic drugs to the general public and arguably helped to glamorize their recreational use, although Huxley himself treated them very seriously.
Huxley was introduced to psychedelic drugs in 1953 by a friend, psychiatrist Dr. Humphry Osmond. Osmond had become interested in hallucinogens and their relationship to mental illness in the 1940s and during the 1950s he made extensive studies of a number of drugs including mescaline and LSD. As noted above, Osmond had some remarkable success in treating alcoholics with LSD.
In May 1953 Osmond gave Huxley his first dose of mescaline, at the Huxley home. In 1954 Huxley recorded his experiences in the landmark book The Doors of Perception; the title was drawn from a quotation by British artist and poet William Blake. Huxley tried LSD for the first time in 1955, obtained from "Captain" Al Hubbard.
Alfred Matthew Hubbard is reputed to have introduced more than 6,000 people to LSD, including scientists, politicians, intelligence officials, diplomats, and church figures. He became known as the original "Captain Trips", travelling about with a leather case containing pharmaceutically pure LSD, mescaline, and psilocybin. He became a 'freelance' apostle for LSD in the early 1950s after supposedly receiving an angelic vision telling him that something important to the future of mankind would soon be coming. When he read about LSD the next year, he immediately sought and acquired LSD, which he tried for himself in 1951.
Although he had no medical training, Hubbard collaborated on running psychedelic sessions with LSD with Ross McLean at Vancouver's Hollywood Hospital, with psychiatrists Abram Hoffer and Humphry Osmond, with Myron Stolaroff at the International Federation for Advanced Study in Menlo Park, and with Willis Harman at Stanford Research Institute (SRI). At various times over the next twenty years, Hubbard also reportedly worked for the Canadian Special Services, the U.S. Justice Department and the U.S. Bureau of Alcohol, Tobacco & Firearms. It is also rumoured that he was involved with the CIA's MK-ULTRA project. How his government positions interacted with his work with LSD is unknown.
Harold A. Abramson
In 1955, Time Magazine reported:
"In Manhattan, Psychiatrist Harold A. Abramson of the Cold Spring Harbor Biological Laboratory has developed a technique of serving dinner to a group of subjects, topping off the meal with a liqueur glass containing 40 micrograms of LSD."
This mention in America's most popular newsweekly is noteworthy because Harold A. Abramson was not a psychiatrist or even a psychologist, but was an allergist who was a key participant in the CIA MK-ULTRA mind-control program.
R. Gordon Wasson
In 1957, R. Gordon Wasson, the vice president of J.P. Morgan, published an article in Life Magazine extolling the virtues of magic mushrooms. This prompted Albert Hofmann to isolate psilocybin in 1958 for distribution by Sandoz with its product LSD in the U.S., further raising interest in LSD in the mass media. Following Wasson's report, Timothy Leary visited Mexico to experience the mushrooms.
Dr. Timothy Leary
Dr. Timothy Leary, a lecturer in psychology at Harvard University, was the most prominent pro-LSD researcher. Leary claimed that using LSD with the right dosage, set (what one brings to the experience), and setting, preferably with the guidance of professionals, could alter behavior in dramatic and beneficial ways.
Dr. Leary began conducting experiments with psilocybin in 1960 on himself and a number of Harvard graduate students after trying hallucinogenic mushrooms used in Native American religious rituals while visiting Mexico. His group began conducting experiments on state prisoners, where they claimed a 90% success rate preventing repeat offenses. Later reexamination of Leary's data reveals his results to be skewed, whether intentionally or not; the percent of men in the study who ended up back in prison later in life was approximately 2% lower than the usual rate. Leary was later introduced to LSD, and he then incorporated that drug into his research as his mental catalyst of choice. Leary claimed that his experiments produced no murders, suicides, psychotic breaks, or bad trips. On the contrary, almost all of Leary's participants reported profound mystical experiences which they felt had a tremendous positive effect on their lives. While it is true that Leary's experiments did not lead to any murders, he willfully chose to ignore the bad trips which occurred, as well as the attempted suicide of a woman the day after she was given mescaline by Leary.
By 1962, faculty discontent with Leary's experiments reached critical mass. Leary was informed that the CIA was monitoring his research (see Government experiments below). Many of the other faculty members had harboured reservations about Leary's research, and powerful parents began complaining to the university about Leary's distribution of hallucinogenic drugs to their children. Further, many undergraduate students who were not part of Leary's research program heard of the profound experiences other students had undergone, and began taking LSD (which was not illegal at the time) recreationally. Leary described LSD as a potent aphrodisiac in an interview with Playboy magazine. When Leary left the University for an extended amount of time during the spring semester, thus failing to fulfill his duties as professor, it was the last straw. Leary and another Harvard psychologist, Richard Alpert, were dismissed from the university in 1963.
In 1964, they published The Psychedelic Experience: A Manual Based on the Tibetan Book of the Dead.
Leary and Alpert, unfazed by their dismissals, relocated first to Mexico, but were expelled from the country by the Mexican government. They then set up at a large private mansion owned by William Hitchcock in New York, known as Millbrook, where they continued their experiments. Their research lost its controlled scientific character as the experiments transformed into LSD parties. Leary later wrote, "We saw ourselves as anthropologists from the twenty-first century inhabiting a time module set somewhere in the Dark Ages of the 1960s. On this space colony we were attempting to create a new paganism and a new dedication to life as art."
A judge who expressed dislike for Dr. Leary's books sentenced him to 30 years in prison for possession of half a marijuana cigarette (which was later reversed by the Supreme Court in Leary v. United States). Publicity surrounding the case further cemented Leary's growing reputation as a counter cultural guru. Around this time, President Richard Nixon described Leary as "the most dangerous man in America." Repeated FBI raids instigated the end of the Millbrook experiment. Leary refocused his efforts towards countering the tremendous amount of anti-LSD propaganda then being issued by the United States government, coining the slogan, "Turn on, tune in, drop out."
Historically, LSD was distributed not for profit, but because those who made and distributed it truly believed that the psychedelic experience could do good for humanity, that it expanded the mind and could bring understanding and love. A limited number of chemists, probably fewer than a dozen, are believed to have manufactured nearly all of the illicit LSD available in the United States. The best known of these is undoubtedly Augustus Owsley Stanley III, usually known simply as Owsley. The former chemistry student set up a private LSD lab in the mid-Sixties in San Francisco and supplied the LSD consumed at the famous Merry Pranksters parties held by Ken Kesey and his Merry Pranksters, and other major events such as the Gathering of the tribes in San Francisco in January 1967. He also had close social connections to leading San Francisco bands the Grateful Dead, Jefferson Airplane, Jefferson Starship, and Big Brother and The Holding Company, regularly supplied them with his LSD and also worked as their live sound engineer and made many tapes of these groups in concert. Owsley's LSD activities — immortalized by Steely Dan in their song "Kid Charlemagne" — ended with his arrest at the end of 1967, but some other manufacturers probably operated continuously for 30 years or more. Announcing Owsley's first bust in 1966, The San Francisco Chronicle's headline "LSD Millionaire Arrested" inspired the rare Grateful Dead song "Alice D. Millionaire."
Ken Kesey was born in La Junta, Colorado to dairy farmers Frederick A. Kesey and Ginevra Smith. In 1946, the family moved to Springfield, Oregon. A champion wrestler in both high school and college, he graduated from Springfield High School in 1953.
Kesey attended the University of Oregon's School of Journalism, where he received a degree in speech and communication in 1957, where he was also a brother of Beta Theta Pi. He was awarded a Woodrow Wilson National Fellowship in 1958 to enroll in the creative writing program at Stanford University, which he did the following year. While at Stanford, he studied under Wallace Stegner and began the manuscript that would become One Flew Over the Cuckoo's Nest.
At Stanford in 1959, Kesey volunteered to take part in a CIA-financed study named Project MKULTRA at the Menlo Park Veterans Hospital. The project studied the effects on the patients of psychoactive drugs, particularly LSD, psilocybin, mescaline, cocaine, AMT, and DMT. Kesey wrote many detailed accounts of his experiences with these drugs, both during the Project MKULTRA study and in the years of private experimentation that followed. Kesey's role as a medical guinea pig inspired him to write One Flew Over the Cuckoo's Nest in 1962. The success of this book, as well as the sale of his residence at Stanford, allowed him to move to La Honda, California, in the mountains southeast of Stanford University. He frequently entertained friends and many others with parties he called "Acid Tests" involving music (such as Kesey's favorite band, The Warlocks, later known as the Grateful Dead), black lights, fluorescent paint, strobes and other "psychedelic" effects, and, of course, LSD. These parties were noted in some of Allen Ginsberg's poems and are also described in Tom Wolfe's The Electric Kool-Aid Acid Test, as well as Hell's Angels: The Strange and Terrible Saga of the Outlaw Motorcycle Gangs by Hunter S. Thompson and Freewheelin Frank, Secretary of the Hell's Angels by Frank Reynolds. Ken Kesey was also said to have experimented with LSD with Ringo Starr in 1965 and in fact influenced the set up for his future performances with The Beatles in the UK.
In 1964, Los Angeles Psychiatrist Sidney Cohen published 'The Beyond Within: the LSD Story'. Cohen had conducted research on the drug's effects at the Veterans Administration Hospital in Los Angeles.
In an interview with Cohen for the publication, Time magazine reported:
[LSD's] effects on the mind... are so fantastic that most experimenters insist words are not the right medium for describing them.
Dr. Cohen and other reputable researchers have been disturbed by what he calls the "beatnik microculture" and its abuses of LSD and other hallucinogens. The danger, he says, is that public reaction against oddball antics may set back serious research for many years.
Secret government experiments
The CIA became interested in LSD when they read reports alleging that American prisoners during the Korean War were being brainwashed with the use of some sort of drug or “lie serum.” LSD was the original centerpiece of the United States Central Intelligence Agency's top secret MK-ULTRA project, an ambitious undertaking conducted from the 1950s through the 1970s designed to explore the possibilities of pharmaceutical mind control. Hundreds of participants, including CIA agents, government employees, military personnel, prostitutes, members of the general public, and mental patients were given LSD, many without their knowledge or consent. The experiments often involved severe psychological torture. To guard against outward reactions, doctors conducted experiments in clinics and laboratories where subjects were monitored by EEG machines and had their words recorded. Some studies investigated whether drugs, stress or specific environmental conditions could be used to break prisoners or to induce confessions. The CIA also created The Society for the Investigation of Human Ecology which was a CIA funding front which provided grants to social scientists and medical researchers investigating questions of interest related to the MK-ULTRA program. Between 1960 and 1963, the CIA gave $856,782 worth of grants to different organizations. The researchers eventually concluded that LSD's effects were too varied and uncontrollable to make it of any practical use as a truth drug, and the project moved on to other substances. It would be decades before the US government admitted the existence of the project and offered apologies to the families of those who had died during the experiments.
From 1960 to 1980
LSD began to be used recreationally in certain (primarily medical) circles. Mainly academics and medical professionals, who became acquainted with LSD in their work, began using it themselves and sharing it with friends and associates. Among the first to do so was British psychiatrist Humphry Osmond.
Psychedelic subculture goes mainstream
LSD historian Jay Stevens, author of the book Storming Heaven: LSD and the American Dream, has said that, in the early days of its recreational use, LSD users (who were at that time mostly academics and medical professionals) fell into two broadly delineated groups. The first group, which was essentially conservative and was exemplified by Huxley, felt that LSD was too powerful and too dangerous to allow its immediate and widespread introduction, and that its use ought to be restricted to the 'elite' members of society — artists, writers, scientists — who could mediate its gradual distribution throughout society. The second and more radical group, typified by Alpert and Leary, felt that LSD had the power to revolutionize society and that it should be spread as widely as possible and be available to all.
During the 1960s, this second 'group' of casual LSD users evolved and expanded into a subculture that extolled the mystical and religious symbolism often engendered by the drug's powerful effects, and advocated its use as a method of raising consciousness. The personalities associated with the subculture, gurus such as Dr. Timothy Leary and psychedelic rock musicians such as the Grateful Dead, Jimi Hendrix, Pink Floyd, Jefferson Airplane and The Beatles soon attracted a great deal of publicity, generating further interest in LSD.
The popularization of LSD outside of the medical world was hastened when individuals such as Ken Kesey participated in drug trials and liked what they saw. Tom Wolfe wrote a widely read account of these early days of LSD's entrance into the non-academic world in his book The Electric Kool Aid Acid Test, which documented the cross-country, acid-fueled voyage of Ken Kesey and the Merry Pranksters on the psychedelic bus "Furthur" and the Pranksters' later 'Acid Test' LSD parties.
In 1965, Sandoz laboratories stopped its still legal shipments of LSD to the United States for research and psychiatric use, after a request from the U.S. government concerned about its use.
Musicians and LSD
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On March 27, 1965, Beatles John Lennon and George Harrison (and their wives) were dosed with LSD without their permission by their dentist, Dr. John Riley. John Lennon mentioned the incident in his famous 1970 Rolling Stone interview, but the name of the dentist was revealed only in 2006.
In 1992, Mike Dirnt of Green Day wrote the famous Longview bassline while under the influence of LSD. In an interview, Green Day lead singer and guitarist Billie Joe Armstrong recalled that he arrived at their house and saw Mike sitting on the floor with highly dilated pupils, holding his bass guitar. Mike looked up at Billie and exclaimed, "Listen to this!"
LSD became a headline item in early 1967. The Beatles, a popular group during the 1960s, admitted to having been under the influence of LSD. Earlier in the year, British tabloid News of the World ran a sensational three-week series on 'drug parties' hosted by rock group The Moody Blues and attended by leading stars including Donovan, The Who's Pete Townshend and Cream drummer Ginger Baker. Largely as a result of collusion between News of the World journalists and the London Drug Squad, many pop stars including Donovan, and Mick Jagger and Keith Richards of The Rolling Stones were arrested for drug possession, although none of the arrests involved LSD.
The music of groups including The Beatles had also begun to show the obvious influence of their experiences with LSD. John Lennon wrote a song which many assumed referred to LSD, "Lucy in the Sky with Diamonds", although John Lennon always dismissed the connection as coincidence. Lennon and Harrison, however, had been experimenting with the drug since 1965. The songs "She Said She Said" (the line,'I know what it's like to be dead' is from an LSD trip the Beatles took with actor Peter Fonda. Fonda said those words repeatedly to John Lennon during the acid trip) and "Tomorrow Never Knows" (many lines of which Lennon borrowed from Leary's "The Psychedelic Experience") from the album Revolver were clearly about LSD trips. During that same time, bands such as Pink Floyd, Jefferson Airplane, and the Grateful Dead helped give birth to a genre known as "psychedelic rock" or acid rock. The FBI suggested in now declassified documents that the Grateful Dead were responsible for introducing LSD to the U.S. The tradition of psychedelic music carried over into the mid seventies when groups like Jefferson Starship recorded songs such as Fading Lady Light that were obviously about LSD trips.
LSD in Australia
LSD was evidently in limited recreational use in Australia in the early 1960s, but is believed to have been initially restricted to those with connections to the scientific and the medical communities. LSD overdose was suggested as a possible cause of the January 2, 1962 deaths of CSIRO scientists Dr Gilbert Bogle and his lover Dr Margaret Chandler, but this is very unlikely as there are no known cases of LSD fatal overdose and other more likely causes of death have been suggested. Large quantities of LSD began to appear in Australia around 1968, and soon permeated the music scene and youth culture in general, especially in the capital cities. The major source of supply during this period is believed to have been American servicemen visiting Australia (mainly Sydney) from Vietnam on 'rest and recreation' (R&R) leave, although the growing connections between American and Australian organized crime in the late 1960s may also have facilitated its importation. Recreational LSD use among young people was on a par with that in other countries in Australia by the early 1970s and continued until late in the decade. LSD is not believed to have been manufactured locally in a significant quantity (if at all) and most if not all supplies were sourced from overseas.
Production of LSD
During the 1960s and early 1970s, the drug culture adopted LSD as the psychedelic drug of choice, particularly amongst the hippie community. However, LSD dramatically decreased in popularity in the mid-1970s. This decline was due to negative publicity centred on side-effects of LSD use (most misleading or patently false), its criminalization, and the increasing effectiveness of drug law enforcement efforts, rather than new medical information. The last country to produce LSD legally (until 1975) was Czechoslovakia; during the 1960s, high-quality LSD was imported from the communist country to California, a fact appreciated by Leary in The Politics of Ecstasy.
The first ever home grown UK 'acid lab' was busted in 1969. Up to then, all LSD had been imported from the U.S. or was remnant produce of Sandoz before it stopped producing LSD. The lab in Kent, and a flat in London were raided simultaneously and quantities of equipment and LSD seized along with the two men who had been making the LSD; Quentin Theobald and Peter Simmons.
The availability of LSD had been drastically reduced by the late 1970s due to a combination of governmental controls and law enforcement. The supply of constituent chemicals including lysergic acid which was used for production of LSD in the 1960s and ergotamine tartrate which was used for production in the 1970s were placed under tight surveillance and government funding for LSD research was almost totally eliminated. These efforts were augmented by a series of major busts in England and Europe. One of the most famous was "Operation Julie" in Britain in 1978, so called after the first name of the female drug squad officer involved; it broke up one of the largest LSD manufacturing and distribution operations in the world at that time, headed by chemist Richard Kemp. The group targeted by the Julie task force were reputed to have had links to the mysterious Brotherhood of Eternal Love and to Ronald Stark.
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LSD made a comeback in the 1980s accompanying the advent of recreational MDMA use, first in the punk and gothic subcultures through dance clubs, then in the 1990s through the acid house scene and rave subculture. LSD use and availability declined sharply following a raid of a large scale LSD lab in 2000 (see LSD in the United States). The lab was run by William Leonard Pickard (now serving two life sentences in prison) and Clyde Apperson (now serving 30 years in prison). Gordon Todd Skinner (who owned the property the lab had been operating on) came to the DEA looking to work as an informant. He and his then-girlfriend Krystle Cole were intimately involved in the case, but were not charged in the bust. The lab was allegedly producing a kilogram of LSD every five weeks, and the US Government contends that LSD supply dropped by 90% following the bust. In the decade after this bust, LSD availability and use has gradually risen. Since the late 1980s, there has also been a revival of hallucinogen research more broadly, which, in recent years, has included preclinical and clinical studies involving LSD and other compounds such as members of the 2C family compounds and psilocybin. In particular, a study released in 2012 highlighted the extraordinary effectiveness of LSD in treating alcoholism.
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- Selvin, Joel (2007-07-12). "For the unrepentant patriarch of LSD, long, strange trip winds back to Bay Area". San Francisco Chronicle. p. A-1. Retrieved 2008-02-01.
- Lehmann-Haupt, Christopher. "Ken Kesey, Author of 'Cuckoo's Nest,' Who Defined the Psychedelic Era, Dies at 66". The New York Times (November 11, 2001). Retrieved on February 21, 2008.
- Baker, Jeff (November 11, 2001). "All times a great artist, Ken Kesey is dead at age 66". The Oregonian. pp. A1.
- Stanford University to La Honda, California, Maps.google.com, 1970-01-01, retrieved 2012-03-20
- Friday, Dec. 18, 1964 (1964-12-18). "Drugs: The Pros & Cons of LSD". TIME. Retrieved 2010-04-20.
- Sullum, Jacob (2011-01-05) 'I Wish I Could Talk in Technicolor', Reason
- Friday, Dec. 18, 1964 (1964-12-18). "Drugs: The Pros & Cons of LSD". TIME. Retrieved 2010-04-20.
- Price H, David: "Buying a Piece of Anthrology Part 1: Human Ecology and Unwitting Anthropological Research for the CIA" Anthropology Today, Vol.23 No.3 pp.8-13
- Friday, Apr. 22, 1966 (1966-04-22). "Drugs: The Dangers of LSD". TIME. Retrieved 2010-04-20.
- Herbert, Ian (2006-09-09). "Revealed: Dentist who introduced Beatles to LSD". The Independent (London).
- Miles 1998, p. 169.
- Brown & Gaines 2002, pp. 171–172.
- LSD in the FBI Vault, countyourculture, retrieved 2012-03-20
- Lim HK, Andrenyak D, Francom P, Foltz RL, Jones RT. Quantification of LSD and N-demethyl-LSD in urine by gas chromatography/resonance electron capture ionization mass spectrometry. Anal Chem. 1988 Jul 15;60(14):1420-5. PMID 3218752
- Langlitz, Nicolas. The Revival of Hallucinogen Research since the Decade of the Brain.. Ph.D. thesis. University of California: Berkeley, 2007. Langlitz, Nicolas "The Persistence of the Subjective in Neuropsychopharmacology. Observations of Contemporary Hallucinogen Research", History of the Human Sciencess, 23:1, 2010, pp. 37-57.
- Lee, Martin A.; Shlain, Bruce (1992). Acid Dreams: The complete social history of LSD: The CIA, the sixties, and beyond. Grove Weidenfeld. ISBN 978-0-8021-3062-4.
- [niu.academia.edu/ThomasRoberts "Why is Bicycle Day April 19th, and not the 16th?"]
- [niu.academia.edu/ThomasRoberts "Bicycle Day, April 19th"]
- Watch Hofmann's Potion, a documentary on the origins of LSD
- LSD Returns--For Psychotherapeutics (Scientific American Magazine article)
- Fan bookmarklet dedicated to LSD anniversary