History of medical diagnosis
The history of medical diagnosis began in earnest from the days of Imhotep in ancient Egypt and Hippocrates in ancient Greece but is far from perfect despite the enormous bounty of information made available by medical research including the sequencing of the human genome. The practice of diagnosis continues to be dominated by theories set down in the early 20th century.
 Ancient Egypt
 Ancient Babylonia
A Babylonian medical textbook, the Diagnostic Handbook written by Esagil-kin-apli (fl. 1069-1046 BC), introduced the use of empiricism, logic and rationality in the diagnosis of an illness or disease. The book made use of logical rules in combining observed symptoms on the body of a patient with its diagnosis and prognosis. He described the symptoms for many varieties of epilepsy and related ailments along with their diagnosis and prognosis which both played significant roles in the practice of Babylonian medicine.
 Ancient China
Predated by Babylonian and Egyptian medicine, traditional Chinese medicine (TCM) was described in an ancient Chinese text, the Yellow Emperor's Inner Canon or Huangdi Neijing which dates to the first or second century BCE. The four diagnostic methods of TCM which are still being practiced today are inspection, listening and smelling, inquiry and palpation.
 Ancient Greece
Over two thousand years ago, Hippocrates recorded the association between disease and heredity. In similar fashion, Pythagoras noted the association between metabolism and heredity (allergy to Fava beans). The medical community, however, has only recently acknowledged the importance of genetics and its relevance to mainstream medicine.
 Islamic world
The Arabic physician, Abu al-Qasim al-Zahrawi (Abulcasis), wrote on hematology in his Al-Tasrif (1000). He provided the first description on haemophilia, a hereditary genetic disorder, in which he wrote of an Andalusian family whose males died of bleeding after minor injuries.
 The Oslerian ideal
The ideals of William Osler, who transformed the practice of medicine in the early 1900s, were based on the principles of the diagnosis and treatment of disease. According to Osler, the functions of a physician were to be able to identify disease and its manifestations and to understand its mechanisms and how it may be prevented or cured. For his medical students he believed that the best textbook was the patient himself—analysis of morbid anatomy and pathology were the keys. The Oslerian ideal continues today as the basis of the doctor's strategy is, "What disease does this patient have, and what is the best way for treatment?" The emphasis is on the classification of the disease in order to use the remedies available for its effects to be reversed or ameliorated. The human being in question is representative of a class of people with this type of disease; this person's biological individuality is not given any great weight.
 Garrod's view
The successor to William Osler as Regius Professor at Oxford was Archibald Garrod. Garrod echoed the observations of his Greek counterparts of two millennia ago, ...our chemical individualities are due to our chemical merits as well as our chemical shortcomings; and it is more nearly true to say that the factors which confer upon us our predispositions to and immunities from various mishaps which are spoken of as diseases, are inherent in our very chemical structure; and even in the molecular groupings which confer upon us our individualities, and which went into the making of the chromosomes from which we sprang. Because Garrod practiced in the early 1900s, well before the knowledge of DNA encoding genes that in turn encoded proteins responsible for bodily structure and functions were discovered, it took some time before medicine could fully appreciate the fundamental importance of his concept of diagnosis.
 Present-day Oslerian practice
Whereas Osler laid the founding principles by which medicine should be practiced, Garrod placed these principles in a greater context of a chemical individuality that is inherited and is subject to the mechanisms of evolutionary selection. The Oslerian ideal of medical practice continues to dominate medical philosophy today. The patient is a collective of symptoms to be characterized and analyzed algorithmically in order to draw a diagnosis and subsequently produce a strategy of treatment. Medicine is about problems based solutions. In keeping with this philosophy, today's pathology reports provide a momentary snapshot of the patient's biochemical profile, highlighting the end result of the disease process.
 Influence of DNA technology
Garrod's conception of biological individuality was confirmed with the advent of the sequencing of the human genome. Finally the subtle relationship between inheritance, individuality and environment became apparent via the variations detected in DNA. In each patient's DNA lies a script for how their bodies will change and become ill as well as how they will handle the assaults of the environment from the beginning of their life to its end. It is hoped that by knowing a patient's genes that the biological strengths and weaknesses in respect to these assaults will be revealed and disease processes can be predicted before they have the opportunity to manifest. Although knowledge in this area is far from complete, there are already medical interventions based on this. More importantly, the physician, forewarned with this knowledge can guide the patient towards appropriate lifestyle changes to anticipate and mitigate disease processes.
- Encyclopedia Britannica
- Horstmanshoff, Stol & Tilburg 2004, pp. 97–98
- Horstmanshoff, Stol & Tilburg 2004, pp. 99
- Stol 1993, p. 5
- Ginzburg 1984, pp. 90–91
- Sivin 1993
- Needham & Lu 1980, pp. 89–90
- Deng 1999, pp. 3–55, 1. Inspection
- Deng 1999, pp. 56–62, 2. Listening and smelling
- Deng 1999, pp. 63–82, 3. Inquiry
- Deng 1999, pp. 83–162, 4. Palpation
- Skinner 2001
- Goodman 2003, p. 155
- Deng, Tietao (1999). "Section One: Examination Methods". Practical Diagnosis in Traditional Chinese Medicine (5th reprint, 2005 ed.). Elsevier. pp. 1–162. ISBN 978-0-443-04582-0. LCCN 98037012. OCLC 98037012.
- Encyclopedia Britannica. "Edwin Smith papyrus". Retrieved 2012-01-28.
- Ginzburg, Carlo (1984). "Morelli, Freud, and Sherlock Holmes: Clues and Scientific Method". In Eco, Umberto; Sebeok, Thomas. The Sign of Three: Dupin, Holmes, Peirce. Bloomington, IN: History Workshop, Indiana University Press. pp. 81–118. ISBN 978-0-253-35235-4. LCCN 82049207. OCLC 9412985. Ginzburg stresses the significance of Babylonian medicine in his discussion of the conjectural paradigm as evidenced by the methods of Giovanni Morelli, Sigmund Freud and Sherlock Holmes in the light of Charles Sanders Peirce's logic of making good guesses or abductive reasoning.
- Goodman, Lenn Evan (2003). Islamic Humanism. Oxford University Press. ISBN 978-0-19-513580-0. LCCN 2002071525. OCLC 472527462.
- Horstmanshoff, H. F. J.; Stol, Marten; Tilburg, Cornelis (2004). Magic and Rationality in Ancient Near Eastern and Graeco-Roman Medicine. Brill Publishers. ISBN 978-90-04-13666-3. LCCN 2004050576. OCLC 217878445.
- LearnTCM.com. "Four diagnostic methods of traditional Chinese medicine". Retrieved 2012-01-28.
- Needham, Joseph; Lu, Gwei-djen (1980). Celestial Lancets. Cambridge: Cambridge University Press. ISBN 978-0-521-21513-8. LCCN 79041734. OCLC 638024213.
- Sivin, Nathan (1993). "Huang-ti nei-ching" [Yellow Emperor's Inner Canon]. In Loewe, Michael. Early Chinese Texts: A Bibliographical Guide. Berkeley: Institute for East Asian Studies, University of California, Berkeley. ISBN 978-1-55729-043-4. LCCN 93040281. OCLC 29356935.
- Skinner, Patricia (2001). "Unani-tibbi" [denotes Arabic or Islamic medicine]. Encyclopedia of Alternative Medicine.
- Stol, Marten (1993). Epilepsy in Babylonia. Brill Publishers. ISBN 978-90-72371-63-8. OCLC 29232876.