Homatropine

Homatropine

Systematic (IUPAC) name
(N-methyl-8-azabicyclo[3.2.1]oct-3-yl) 2-hydroxy-2-phenylacetate
Clinical data
AHFS/Drugs.com	monograph
MedlinePlus	a601006
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	87-00-3 N
ATC code	A02BX03 S01FA05
PubChem	CID 6321423
DrugBank	APRD01017
ChemSpider	16498795 Y
UNII	8QS6WCL55Z Y
ChEMBL	CHEMBL1233442 N
Chemical data
Formula	C16H21NO3
Mol. mass	356.26 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C16H21NO3/c1-17-12-7-8-13(17)10-14(9-12)20-16(19)15(18)11-5-3-2-4-6-11/h2-6,12-15,18H,7-10H2,1H3/t12-,13+,14+,15? Y Key:ZTVIKZXZYLEVOL-MCOXGKPRSA-N Y
N(what is this?)  (verify)

Homatropine (Equipin, Isopto Homatropine) is an anticholinergic medication that inhibits muscarinic acetylcholine receptors and thus the parasympathetic nervous system. It is used in eye drops as a cycloplegic, to temporarily paralyze accommodation, and as a mydriatic, to dilate the pupil. For Homatropine methylbromide see Methylhomatropine, this is a different medication. Homatropine is less potent than atropine and has a shorter duration of action. It is available as the hydrobromide salt.

Homatropine is also given as an atropine substitute given to reverse the muscarinic and CNS effects associated with indirect cholinomimetic (anti-AChase) administration.

Side effects

• Blurred vision
• Sensitivity to light

Contraindications

• Untreated glaucoma
• Myasthenia gravis
• Severe heart failure
• Thyrotoxicosis