Homatropine

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Homatropine
HomatropineNEW.png
Systematic (IUPAC) name
(N-methyl-8-azabicyclo[3.2.1]oct-3-yl) 2-hydroxy-2-phenylacetate
Clinical data
AHFS/Drugs.com monograph
MedlinePlus a601006
Legal status
  • rx only not FDA approved only sold in UK
Identifiers
CAS number 87-00-3 N
ATC code A02BX03 S01FA05
PubChem CID 6321423
DrugBank DB00725
ChemSpider 16498795 YesY
UNII 8QS6WCL55Z YesY
ChEMBL CHEMBL1233442 N
Chemical data
Formula C16H21NO3 
Mol. mass 356.26 g/mol
 N (what is this?)  (verify)

Homatropine (Equipin, Isopto Homatropine) is an anticholinergic medication that is an antagonist at muscarinic acetylcholine receptors and thus the parasympathetic nervous system. It is used in eye drops as a cycloplegic (to temporarily paralyze accommodation), and as a mydriatic (to dilate the pupil). For Homatropine methylbromide see Methylhomatropine, this is a different medication. Homatropine is less potent than atropine and has a shorter duration of action. It is available as the hydrobromide salt.

Homatropine is also given as an atropine substitute given to reverse the muscarinic and CNS effects associated with indirect cholinomimetic (anti-AChase) administration.

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