Methylhomatropine

Homatropine methyl bromide

Systematic (IUPAC) name
(N,N-dimethyl-8-azoniabicyclo[3.2.1]oct-3-yl) 2-hydroxy-2-phenylacetate bromide
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	80-49-9
ATC code	A02BX03
PubChem	CID 6646
DrugBank	APRD01017
ChemSpider	6394 Y
UNII	68JRS2HC1C Y
ChEMBL	CHEMBL1200851
Chemical data
Formula	C17H24BrNO3
Mol. mass	356.26 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C17H24NO3.BrH/c1-18(2)13-8-9-14(18)11-15(10-13)21-17(20)16(19)12-6-4-3-5-7-12;/h3-7,13-16,19H,8-11H2,1-2H3;1H/q+1;/p-1/t13-,14+,15+,16?; Y Key:ZTVIKZXZYLEVOL-MCOXGKPRSA-N Y
Y(what is this?)  (verify)

Homatropine methylbromide or Methylhomatropine bromide is a quaternary ammonium salt of methylhomatropine. It is a peripherally acting anticholinergic medication that inhibits muscarinic acetylcholine receptors and thus the parasympathetic nervous system. It does not cross the blood-brain barrier. It is used, in addition to papaverine, as component of mild drugs that help "flush" the bile.

Certain preparations of drugs such as hydrocodone are mixed with a small, sub-therapeutic amount homatropine methylbromide to discourage intentional overdose.

Contraindications

• Untreated glaucoma
• Myasthenia gravis
• Severe heart failure
• Thyrotoxicosis