The community received its name because its first post office was located in the "home" of postmaster Hugh Cannon in 1834.
The town became famous as the setting for an episode of the television show The X-Files entitled "Home" which originally aired on October 11, 1996. In the episode, Home is depicted as an idyllic "Mayberry" like town clouded by a reclusive local family with a dark secret. Although the episode was set in the town, it was actually filmed near Fort Langley, British Columbia.
The author Edward Abbey moved to Home in 1931, having been born in the Indiana hospital and spending the first four-and-a-half years in other towns and villages in the area. Abbey, known for his great depictions of nature and its beauty, was said to have gotten much of his inspiration from growing up in Home.
The town was called Kellysburg until the early 1900s. Harry Burkett and his family moved to town in 1918. Harry Burkett started the post office in his home, which led to the town's name: everyone talked about going to the home post office, and eventually the town's name was changed from Kellysburg to Home.[contradictory]