Akpan was charged with misconduct by the FA in November 2011, after homophobic comments were posted on his Twitter account. Despite insisting that someone else had posted the comments, he admitted the charge after no one came forward to claim responsibility, and he was fined £1,200 by the Football Association. On 14 April 2012 Akpan was sent off in a game against AFC Wimbledon due to a challenge that broke Jason Prior's leg in two places.
Akpan signed for Premier League side Reading on a three-and-a-half-year contract on 8 January 2013. He stated his desire to help his new club avoid relegation.