Horatio Southgate (July 5, 1812 – April 11, 1894) was born in Portland, Maine and studied for the ordained ministry at Andover Theological Seminary as a Congregationalist. In 1834 he became a member of the Episcopal Church in the United States of America, and was subsequently ordained to the diaconate in 1835. He was ordained to the priesthood in 1839 after an unusually long diaconate for this period in Anglican history.
Southgate was consecrated as a missionary bishop "for the dominions and dependencies of the Sultan" (i.e., the Ottoman Empire) on October 26, 1844, following on several years of travels in what are now Turkey, Iran, Iraq and other parts of the Middle East. His contacts with Jacobite, Nestorian, Assyrian and other Christian communities in this region marked significant early relations with the American Protestant Episcopal Church. He was accompanied by other clergymen of the Episcopal Church, including Samuel Penny, and engaged in controversy with other Anglo-American missionary groups in the region.
He returned to the United States in 1849, serving as rector of Saint Luke's Church, Portland, Maine (1850–1851); the Church of the Advent, Boston (1852–1858); and Zion Church, New York City (1858–1872). Horatio Southgate died in Astoria, Queens.
- Narrative of a Tour through Armenia, Kurdistan, Persia, and Mesopotamia (two volumes, New York, 1840)
- Narrative of a Visit to the Syrian (Jacobite) Church of Mesopotamia (1844)
- A Treatise on the Antiquity, Doctrine, Ministry, and Worship of the Anglican Church (In Greek, Constantinople, 1849)
- Practical Directions for the Observance of Lent (New York, 1850)
- The War in the East (London, 1855)
- Parochial Sermons (1859)
- The Cross above the Crescent, a Romance of Constantinople (Philadelphia, 1877)
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