Host cell factor C1

Host cell factor C1 (VP16-accessory protein)
Identifiers
Symbols	HCFC1; CFF; HCF-1; HCF1; HFC1; MGC70925; VCAF
External IDs	OMIM: 300019 MGI: 105942 HomoloGene: 3898 GeneCards: HCFC1 Gene
Gene Ontology
Molecular function	• chromatin binding; • sequence-specific DNA binding transcription factor activity; • transcription coactivator activity; • protein binding; • identical protein binding;
Cellular component	• nucleus; • Ada2/Gcn5/Ada3 transcription activator complex; • nucleolus; • cytoplasm; • mitochondrion; • Set1C/COMPASS complex; • SAGA-type complex; • MLL5-L complex; • MLL1 complex;
Biological process	• transcription, DNA-dependent; • regulation of transcription, DNA-dependent; • regulation of transcription, DNA-dependent; • transcription from RNA polymerase II promoter; • positive regulation of gene expression; • reactivation of latent virus; • regulation of protein complex assembly; • interspecies interaction between organisms; • positive regulation of cell cycle; • protein stabilization;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs

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Host cell factor is a protein that in humans is encoded by the HCFC1 gene.^[1]^[2]

This gene is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear coactivator is proteolytically cleaved at one of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains. The protein is involved in control of the cell cycle and transcriptional regulation during herpes simplex virus infection. Alternatively spliced variants that encode different protein isoforms have been described; however, not all variants have been fully characterized.^[2]

[edit] Interactions

Host cell factor C1 has been shown to interact with HDAC1,^[3] Histone deacetylase 2,^[3] OGT,^[3] SIN3A,^[4]^[3] SUDS3,^[3] ZBTB17,^[5] Sp1 transcription factor,^[3]^[6] MLL,^[4] PPP1CA,^[7] POU2F1,^[8]^[9] PDCD2,^[10] WDR5,^[4]^[3] CREB3,^[11]^[12]GABPA^[13] and BAP1.^[14]

[edit] References

^ Wilson AC, LaMarco K, Peterson MG, Herr W (Aug 1993). "The VP16 accessory protein HCF is a family of polypeptides processed from a large precursor protein". Cell 74 (1): 115–25. doi:10.1016/0092-8674(93)90299-6. PMID 8392914.
^ ^a ^b "Entrez Gene: HCFC1 host cell factor C1 (VP16-accessory protein)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3054.
^ ^a ^b ^c ^d ^e ^f ^g Wysocka, Joanna; Myers Michael P, Laherty Carol D, Eisenman Robert N, Herr Winship (Apr. 2003). "Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1". Genes Dev. (United States) 17 (7): 896–911. doi:10.1101/gad.252103. ISSN 0890-9369. PMC 196026. PMID 12670868. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=196026.
^ ^a ^b ^c Yokoyama, Akihiko; Wang Zhong, Wysocka Joanna, Sanyal Mrinmoy, Aufiero Deborah J, Kitabayashi Issay, Herr Winship, Cleary Michael L (Jul. 2004). "Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression". Mol. Cell. Biol. (United States) 24 (13): 5639–49. doi:10.1128/MCB.24.13.5639-5649.2004. ISSN 0270-7306. PMC 480881. PMID 15199122. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=480881.
^ Piluso, David; Bilan Patricia, Capone John P (Nov. 2002). "Host cell factor-1 interacts with and antagonizes transactivation by the cell cycle regulatory factor Miz-1". J. Biol. Chem. (United States) 277 (48): 46799–808. doi:10.1074/jbc.M206226200. ISSN 0021-9258. PMID 12244100.
^ Gunther, M; Laithier M, Brison O (Jul. 2000). "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening". Mol. Cell. Biochem. (NETHERLANDS) 210 (1–2): 131–42. doi:10.1023/A:1007177623283. ISSN 0300-8177. PMID 10976766.
^ Ajuh, P M; Browne G J, Hawkes N A, Cohen P T, Roberts S G, Lamond A I (Feb. 2000). "Association of a protein phosphatase 1 activity with the human factor C1 (HCF) complex". Nucleic Acids Res. (ENGLAND) 28 (3): 678–86. doi:10.1093/nar/28.3.678. PMC 102561. PMID 10637318. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=102561.
^ La Boissière, S; Hughes T, O'Hare P (Jan. 1999). "HCF-dependent nuclear import of VP16". EMBO J. (ENGLAND) 18 (2): 480–9. doi:10.1093/emboj/18.2.480. ISSN 0261-4189. PMC 1171141. PMID 9889203. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171141.
^ Kristie, T M; Sharp P A (Mar. 1993). "Purification of the cellular C1 factor required for the stable recognition of the Oct-1 homeodomain by the herpes simplex virus alpha-trans-induction factor (VP16)". J. Biol. Chem. (UNITED STATES) 268 (9): 6525–34. ISSN 0021-9258. PMID 8454622.
^ Scarr, Rebecca B; Sharp Phillip A (Aug. 2002). "PDCD2 is a negative regulator of HCF-1 (C1)". Oncogene (England) 21 (34): 5245–54. doi:10.1038/sj.onc.1205647. ISSN 0950-9232. PMID 12149646.
^ Lu, R; Yang P, Padmakumar S, Misra V (Aug. 1998). "The herpesvirus transactivator VP16 mimics a human basic domain leucine zipper protein, luman, in its interaction with HCF". J. Virol. (UNITED STATES) 72 (8): 6291–7. ISSN 0022-538X. PMC 109766. PMID 9658067. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=109766.
^ Freiman, R N; Herr W (Dec. 1997). "Viral mimicry: common mode of association with HCF by VP16 and the cellular protein LZIP". Genes Dev. (UNITED STATES) 11 (23): 3122–7. doi:10.1101/gad.11.23.3122. ISSN 0890-9369. PMC 316754. PMID 9389645. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=316754.
^ Vogel, J L; Kristie T M (Feb. 2000). "The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABP". EMBO J. (ENGLAND) 19 (4): 683–90. doi:10.1093/emboj/19.4.683. ISSN 0261-4189. PMC 305606. PMID 10675337. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=305606.
^ Machida YJ, Machida Y, Vashisht AA, Wohlschlegel JA, Dutta A (2009). "The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1". J Biol Chem. 284 (49): 34179-88. PMC 2797188. PMID 19815555. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2797188.

[edit] Further reading

Oehler T, Angel P (1992). "A common intermediary factor (p52/54) recognizing "acidic blob"-type domains is required for transcriptional activation by the Jun proteins". Mol. Cell. Biol. 12 (12): 5508–15. PMC 360488. PMID 1448082. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=360488.
Wilson AC, Peterson MG, Herr W (1995). "The HCF repeat is an unusual proteolytic cleavage signal". Genes Dev. 9 (20): 2445–58. doi:10.1101/gad.9.20.2445. PMID 7590226.
Klemm RD, Goodrich JA, Zhou S, Tjian R (1995). "Molecular cloning and expression of the 32-kDa subunit of human TFIID reveals interactions with VP16 and TFIIB that mediate transcriptional activation". Proc. Natl. Acad. Sci. U.S.A. 92 (13): 5788–92. doi:10.1073/pnas.92.13.5788. PMC 41586. PMID 7597030. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=41586.
Frattini A, Faranda S, Redolfi E, et al. (1995). "Genomic organization of the human VP16 accessory protein, a housekeeping gene (HCFC1) mapping to Xq28". Genomics 23 (1): 30–5. doi:10.1006/geno.1994.1455. PMID 7829097.
Kristie TM, Pomerantz JL, Twomey TC, et al. (1995). "The cellular C1 factor of the herpes simplex virus enhancer complex is a family of polypeptides". J. Biol. Chem. 270 (9): 4387–94. doi:10.1074/jbc.270.9.4387. PMID 7876203.
Kristie TM, Sharp PA (1993). "Purification of the cellular C1 factor required for the stable recognition of the Oct-1 homeodomain by the herpes simplex virus alpha-trans-induction factor (VP16)". J. Biol. Chem. 268 (9): 6525–34. PMID 8454622.
Zoppè M, Frattini A, Faranda S, Vezzoni P (1996). "The complete sequence of the host cell factor 1 (HCFC1) gene and its promoter: a role for YY1 transcription factor in the regulation of its expression". Genomics 34 (1): 85–91. doi:10.1006/geno.1996.0244. PMID 8661027.
Wilson AC, Freiman RN, Goto H, et al. (1997). "VP16 targets an amino-terminal domain of HCF involved in cell cycle progression". Mol. Cell. Biol. 17 (10): 6139–46. PMC 232464. PMID 9315674. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=232464.
Freiman RN, Herr W (1998). "Viral mimicry: common mode of association with HCF by VP16 and the cellular protein LZIP". Genes Dev. 11 (23): 3122–7. doi:10.1101/gad.11.23.3122. PMC 316754. PMID 9389645. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=316754.
Lu R, Yang P, Padmakumar S, Misra V (1998). "The herpesvirus transactivator VP16 mimics a human basic domain leucine zipper protein, luman, in its interaction with HCF". J. Virol. 72 (8): 6291–7. PMC 109766. PMID 9658067. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=109766.
Ge H, Si Y, Roeder RG (1999). "Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation". EMBO J. 17 (22): 6723–9. doi:10.1093/emboj/17.22.6723. PMC 1171017. PMID 9822615. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171017.
La Boissière S, Hughes T, O'Hare P (1999). "HCF-dependent nuclear import of VP16". EMBO J. 18 (2): 480–9. doi:10.1093/emboj/18.2.480. PMC 1171141. PMID 9889203. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171141.
Lu R, Misra V (2000). "Potential role for luman, the cellular homologue of herpes simplex virus VP16 (alpha gene trans-inducing factor), in herpesvirus latency". J. Virol. 74 (2): 934–43. doi:10.1128/JVI.74.2.934-943.2000. PMC 111614. PMID 10623756. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=111614.
Mahajan SS, Wilson AC (2000). "Mutations in host cell factor 1 separate its role in cell proliferation from recruitment of VP16 and LZIP". Mol. Cell. Biol. 20 (3): 919–28. doi:10.1128/MCB.20.3.919-928.2000. PMC 85209. PMID 10629049. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=85209.
Ajuh PM, Browne GJ, Hawkes NA, et al. (2000). "Association of a protein phosphatase 1 activity with the human factor C1 (HCF) complex". Nucleic Acids Res. 28 (3): 678–86. doi:10.1093/nar/28.3.678. PMC 102561. PMID 10637318. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=102561.
Vogel JL, Kristie TM (2000). "The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABP". EMBO J. 19 (4): 683–90. doi:10.1093/emboj/19.4.683. PMC 305606. PMID 10675337. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=305606.
Scarr RB, Smith MR, Beddall M, Sharp PA (2000). "A novel 50-kilodalton fragment of host cell factor 1 (C1) in G(0) cells". Mol. Cell. Biol. 20 (10): 3568–75. doi:10.1128/MCB.20.10.3568-3575.2000. PMC 85649. PMID 10779346. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=85649.
Choi Y, Asada S, Uesugi M (2000). "Divergent hTAFII31-binding motifs hidden in activation domains". J. Biol. Chem. 275 (21): 15912–6. doi:10.1074/jbc.275.21.15912. PMID 10821850.
Lu R, Misra V (2000). "Zhangfei: a second cellular protein interacts with herpes simplex virus accessory factor HCF in a manner similar to Luman and VP16". Nucleic Acids Res. 28 (12): 2446–54. doi:10.1093/nar/28.12.2446. PMC 102720. PMID 10871379. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=102720.

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[pmid8392914-0] Wilson AC, LaMarco K, Peterson MG, Herr W (Aug 1993). "The VP16 accessory protein HCF is a family of polypeptides processed from a large precursor protein". Cell 74 (1): 115–25. doi:10.1016/0092-8674(93)90299-6. PMID 8392914.

[entrez-1] "Entrez Gene: HCFC1 host cell factor C1 (VP16-accessory protein)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3054.

[pmid12670868-2] ^ ^a ^b ^c ^d ^e ^f ^g Wysocka, Joanna; Myers Michael P, Laherty Carol D, Eisenman Robert N, Herr Winship (Apr. 2003). "Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1". Genes Dev. (United States) 17 (7): 896–911. doi:10.1101/gad.252103. ISSN 0890-9369. PMC 196026. PMID 12670868. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=196026.

[pmid15199122-3] Yokoyama, Akihiko; Wang Zhong, Wysocka Joanna, Sanyal Mrinmoy, Aufiero Deborah J, Kitabayashi Issay, Herr Winship, Cleary Michael L (Jul. 2004). "Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression". Mol. Cell. Biol. (United States) 24 (13): 5639–49. doi:10.1128/MCB.24.13.5639-5649.2004. ISSN 0270-7306. PMC 480881. PMID 15199122. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=480881.

[pmid12244100-4] Piluso, David; Bilan Patricia, Capone John P (Nov. 2002). "Host cell factor-1 interacts with and antagonizes transactivation by the cell cycle regulatory factor Miz-1". J. Biol. Chem. (United States) 277 (48): 46799–808. doi:10.1074/jbc.M206226200. ISSN 0021-9258. PMID 12244100.

[pmid10976766-5] Gunther, M; Laithier M, Brison O (Jul. 2000). "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening". Mol. Cell. Biochem. (NETHERLANDS) 210 (1–2): 131–42. doi:10.1023/A:1007177623283. ISSN 0300-8177. PMID 10976766.

[pmid10637318-6] Ajuh, P M; Browne G J, Hawkes N A, Cohen P T, Roberts S G, Lamond A I (Feb. 2000). "Association of a protein phosphatase 1 activity with the human factor C1 (HCF) complex". Nucleic Acids Res. (ENGLAND) 28 (3): 678–86. doi:10.1093/nar/28.3.678. PMC 102561. PMID 10637318. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=102561.

[pmid9889203-7] La Boissière, S; Hughes T, O'Hare P (Jan. 1999). "HCF-dependent nuclear import of VP16". EMBO J. (ENGLAND) 18 (2): 480–9. doi:10.1093/emboj/18.2.480. ISSN 0261-4189. PMC 1171141. PMID 9889203. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171141.

[pmid8454622-8] Kristie, T M; Sharp P A (Mar. 1993). "Purification of the cellular C1 factor required for the stable recognition of the Oct-1 homeodomain by the herpes simplex virus alpha-trans-induction factor (VP16)". J. Biol. Chem. (UNITED STATES) 268 (9): 6525–34. ISSN 0021-9258. PMID 8454622.

[pmid12149646-9] Scarr, Rebecca B; Sharp Phillip A (Aug. 2002). "PDCD2 is a negative regulator of HCF-1 (C1)". Oncogene (England) 21 (34): 5245–54. doi:10.1038/sj.onc.1205647. ISSN 0950-9232. PMID 12149646.

[pmid9658067-10] Lu, R; Yang P, Padmakumar S, Misra V (Aug. 1998). "The herpesvirus transactivator VP16 mimics a human basic domain leucine zipper protein, luman, in its interaction with HCF". J. Virol. (UNITED STATES) 72 (8): 6291–7. ISSN 0022-538X. PMC 109766. PMID 9658067. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=109766.

[pmid9389645-11] Freiman, R N; Herr W (Dec. 1997). "Viral mimicry: common mode of association with HCF by VP16 and the cellular protein LZIP". Genes Dev. (UNITED STATES) 11 (23): 3122–7. doi:10.1101/gad.11.23.3122. ISSN 0890-9369. PMC 316754. PMID 9389645. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=316754.

[pmid10675337-12] Vogel, J L; Kristie T M (Feb. 2000). "The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABP". EMBO J. (ENGLAND) 19 (4): 683–90. doi:10.1093/emboj/19.4.683. ISSN 0261-4189. PMC 305606. PMID 10675337. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=305606.

[pmid19815555-13] Machida YJ, Machida Y, Vashisht AA, Wohlschlegel JA, Dutta A (2009). "The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1". J Biol Chem. 284 (49): 34179-88. PMC 2797188. PMID 19815555. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2797188.

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Host cell factor C1

[edit] Interactions

[edit] References

[edit] Further reading

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