Hotelling's T-squared distribution

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In statistics Hotelling's T-squared distribution is a univariate distribution proportional to the F-distribution and arises importantly as the distribution of a set of statistics which are natural generalizations of the statistics underlying Student's t-distribution. In particular, the distribution arises in multivariate statistics in undertaking tests of the differences between the (multivariate) means of different populations, where tests for univariate problems would make use of a t-test.

The distribution is named for Harold Hotelling, who developed it[1] as a generalization of Student's t-distribution.

The distribution[edit]

If the vector pd1 is Gaussian multivariate-distributed with zero mean and unit covariance matrix N(p01,pIp) and mMp is a p x p matrix with a Wishart distribution with unit scale matrix and m degrees of freedom W(pIp,m) then m(1d' pM−1pd1) has a Hotelling T2 distribution with dimensionality parameter p and m degrees of freedom.[2]

If the notation T^2_{p,m} is used to denote a random variable having Hotelling's T-squared distribution with parameters p and m then, if a random variable X has Hotelling's T-squared distribution,


X \sim T^2_{p,m}

then[1]


\frac{m-p+1}{pm} X\sim F_{p,m-p+1}

where F_{p,m-p+1} is the F-distribution with parameters p and m−p+1.

Hotelling's T-squared statistic[edit]

Hotelling's T-squared statistic is a generalization of Student's t statistic that is used in multivariate hypothesis testing, and is defined as follows.[1]

Let \mathcal{N}_p(\boldsymbol{\mu},{\mathbf \Sigma}) denote a p-variate normal distribution with location \boldsymbol{\mu} and covariance {\mathbf \Sigma}. Let

{\mathbf x}_1,\dots,{\mathbf x}_n\sim \mathcal{N}_p(\boldsymbol{\mu},{\mathbf \Sigma})

be n independent random variables, which may be represented as p\times1 column vectors of real numbers. Define

\overline{\mathbf x}=\frac{\mathbf{x}_1+\cdots+\mathbf{x}_n}{n}

to be the sample mean. It can be shown that


n(\overline{\mathbf x}-\boldsymbol{\mu})'{\mathbf \Sigma}^{-1}(\overline{\mathbf x}-\boldsymbol{\mathbf\mu})\sim\chi^2_p ,

where \chi^2_p is the chi-squared distribution with p degrees of freedom. To show this use the fact that \overline{\mathbf x}\sim \mathcal{N}_p(\boldsymbol{\mu},{\mathbf \Sigma}/n) and then derive the characteristic function of the random variable \mathbf y=n(\overline{\mathbf x}-\boldsymbol{\mu})'{\mathbf \Sigma}^{-1}(\overline{\mathbf x}-\boldsymbol{\mathbf\mu}). This is done below,

\phi_{\mathbf y}(\theta)=\operatorname{E} e^{i \theta \mathbf y},
=\operatorname{E} e^{i \theta n(\overline{\mathbf x}-\boldsymbol{\mu})'{\mathbf \Sigma}^{-1}(\overline{\mathbf x}-\boldsymbol{\mathbf\mu})}
= \int e^{i \theta n(\overline{\mathbf x}-\boldsymbol{\mu})'{\mathbf \Sigma}^{-1}(\overline{\mathbf x}-\boldsymbol{\mathbf\mu})} (2\pi)^{-\frac{p}{2}}|\boldsymbol\Sigma/n|^{-\frac{1}{2}}\, e^{ -\frac{1}{2}n(\overline{\mathbf x}-\boldsymbol\mu)'\boldsymbol\Sigma^{-1}(\overline{\mathbf x}-\boldsymbol\mu) }\,dx_{1}...dx_{p}
= \int (2\pi)^{-\frac{p}{2}}|\boldsymbol\Sigma/n|^{-\frac{1}{2}}\, e^{ -\frac{1}{2}n(\overline{\mathbf x}-\boldsymbol\mu)'(\boldsymbol\Sigma^{-1}-2 i \theta \boldsymbol\Sigma^{-1})(\overline{\mathbf x}-\boldsymbol\mu) }\,dx_{1}...dx_{p},
= |(\boldsymbol\Sigma^{-1}-2 i \theta \boldsymbol\Sigma^{-1})^{-1}/n|^{\frac{1}{2}} |\boldsymbol\Sigma/n|^{-\frac{1}{2}} \int (2\pi)^{-\frac{p}{2}} |(\boldsymbol\Sigma^{-1}-2 i \theta \boldsymbol\Sigma^{-1})^{-1}/n|^{-\frac{1}{2}} \, e^{ -\frac{1}{2}n(\overline{\mathbf x}-\boldsymbol\mu)'(\boldsymbol\Sigma^{-1}-2 i \theta \boldsymbol\Sigma^{-1})(\overline{\mathbf x}-\boldsymbol\mu) }\,dx_{1}...dx_{p},
= |(\mathbf I_p-2 i \theta \mathbf I_p)|^{-\frac{1}{2}},
= (1-2 i \theta)^{-\frac{p}{2}}.~~\blacksquare

However, {\mathbf \Sigma} is often unknown and we wish to do hypothesis testing on the location \boldsymbol{\mu}.

Sum of p squared t's[edit]

Define

{\mathbf W}=\frac{1}{n-1}\sum_{i=1}^n (\mathbf{x}_i-\overline{\mathbf x})(\mathbf{x}_i-\overline{\mathbf x})'

to be the sample covariance. Here we denote transpose by an apostrophe. It can be shown that \mathbf W is positive-definite and (n-1)\mathbf W follows a p-variate Wishart distribution with n−1 degrees of freedom.[3] Hotelling's T-squared statistic is then defined[4] to be


t^2=n(\overline{\mathbf x}-\boldsymbol{\mu})'{\mathbf W}^{-1}(\overline{\mathbf x}-\boldsymbol{\mathbf\mu})

and, also from above,

t^2 \sim T^2_{p,n-1}

i.e.

\frac{n-p}{p(n-1)}t^2 \sim F_{p,n-p} ,

where F_{p,n-p} is the F-distribution with parameters p and n−p. In order to calculate a p value, multiply the t2 statistic by the above constant and use the F-distribution.

Hotelling's two-sample T-squared statistic[edit]

If {\mathbf x}_1,\dots,{\mathbf x}_{n_x}\sim N_p(\boldsymbol{\mu},{\mathbf V}) and {\mathbf y}_1,\dots,{\mathbf y}_{n_y}\sim N_p(\boldsymbol{\mu},{\mathbf V}), with the samples independently drawn from two independent multivariate normal distributions with the same mean and covariance, and we define

\overline{\mathbf x}=\frac{1}{n_x}\sum_{i=1}^{n_x} \mathbf{x}_i \qquad \overline{\mathbf y}=\frac{1}{n_y}\sum_{i=1}^{n_y} \mathbf{y}_i

as the sample means, and

{\mathbf W}= \frac{\sum_{i=1}^{n_x}(\mathbf{x}_i-\overline{\mathbf x})(\mathbf{x}_i-\overline{\mathbf x})'
+\sum_{i=1}^{n_y}(\mathbf{y}_i-\overline{\mathbf y})(\mathbf{y}_i-\overline{\mathbf y})'}{n_x+n_y-2}

as the unbiased pooled covariance matrix estimate, then Hotelling's two-sample T-squared statistic is

t^2 = \frac{n_x n_y}{n_x+n_y}(\overline{\mathbf x}-\overline{\mathbf y})'{\mathbf W}^{-1}(\overline{\mathbf x}-\overline{\mathbf y})
\sim T^2(p, n_x+n_y-2)

and it can be related to the F-distribution by[3]

\frac{n_x+n_y-p-1}{(n_x+n_y-2)p}t^2 \sim F(p,n_x+n_y-1-p).

The non-null distribution of this statistic is the noncentral F-distribution (the ratio of a non-central Chi-squared random variable and an independent central Chi-squared random variable)

\frac{n_x+n_y-p-1}{(n_x+n_y-2)p}t^2 \sim F(p,n_x+n_y-1-p;\delta),

with

\delta = \frac{n_x n_y}{n_x+n_y}\boldsymbol{\nu}'\mathbf{V}^{-1}\boldsymbol{\nu},

where \boldsymbol{\nu} is the difference vector between the population means.

More robust and powerful tests than Hotelling's two-sample test have been proposed in the literature, see for example the interpont distance based tests which can be applied also when the number of variables is comparable with, or even larger than, the number of subjects.[5][6]

See also[edit]

References[edit]

  1. ^ a b c Hotelling, H. (1931). "The generalization of Student's ratio". Annals of Mathematical Statistics 2 (3): 360–378. doi:10.1214/aoms/1177732979. 
  2. ^ Eric W. Weisstein, CRC Concise Encyclopedia of Mathematics, Second Edition, Chapman & Hall/CRC, 2003, p. 1408
  3. ^ a b Mardia, K. V.; Kent, J. T.; Bibby, J. M. (1979). Multivariate Analysis. Academic Press. ISBN 0-12-471250-9. 
  4. ^ http://www.itl.nist.gov/div898/handbook/pmc/section5/pmc543.htm
  5. ^ Marozzi, M. (2014). "Multivariate tests based on interpoint distances with application to magnetic resonance imaging". Statistical Methods in Medical Research. doi:10.1177/0962280214529104. 
  6. ^ Marozzi, M. (2015). "Multivariate multidistance tests for high-dimensional low sample size case-control studies". Statistics in Medicine 34. doi:10.1002/sim.6418. 

External links[edit]