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Human-in-the-Loop or HITL is defined as a model that requires human interaction. HITL is associated with Virtual Modeling & Simulation (M&S) in the Live, Virtual, and Constructive taxonomy. HITL models may conform to Human factors requirements as is the case of a Mockup. In this type of simulation a human is always part of the simulation and consequently influences the outcome in such a way that is difficult if not impossible to reproduce exactly. HITL also readily allows for the identification of problems and requirements that may not be easily identified by other means of simulation.
HITL is often referred to as interactive simulation which is a special kind of physical simulation in which physical simulations include human operators, such as in a Flight simulator or a driving simulator.
Human-in-the-Loop lends itself the ability for the user to change the outcome of an event or process. HITL is extremely effective for the purposes of training because it allows the trainee to immerse themselves in the event or process. The immersion effectively contributes to a positive transfer of skills acquired to the real world. This can be demonstrated by trainees utilizing flight simulators in preparation to become pilots.
HITL also allows for the acquisition of knowledge in regards to how a new process may impact a particular event. Utilizing HITL allows participants to interact with realistic models and attempt to perform as they would in an actual scenario. HITL simulations bring to the surface issues that would not otherwise be apparent until after a new process has been deployed. A real world example of HITL simulation as an evaluation tool is the Federal Aviation Administration’s (FAA) use of HITL simulation to allow air traffic controllers to test new automation procedures by allowing controllers to direct the activities of simulated air traffic while monitoring the impact the newly implemented procedures.
With almost any process there always remains the human element which can only be reproduced using HITL simulation. Although much of can be done to automate systems humans typically still need to take the information provided by a system to determine the next course of action based on their judgment and experience. Intelligent systems can only go so far in certain circumstances to automate a process, only real humans in the simulation can accurately judge the final design. Table top simulation may be useful in the very early stages of project development for the purpose of collecting data to set broad parameters, but the important decisions require human-in-the-loop simulation.
 Human-in-the-Loop Simulation within Virtual Simulation Taxonomy
Virtual simulations inject Human-in-the-Loop in a central role by exercising motor control skills (i.e., flying an airplane), decision making skills (i.e., committing fire control resources to action), or communication skills (i.e., as members of a C4I team).
 Examples of Human-in-the-Loop Simulators
- Flight Simulators
- Driving Simulators
- Marine Simulators
- Select Computer & Video Games
Although human-in-the-loop simulation can include a computer simulation in the form of a synthetic environment, computer simulation is not always a form of human-in-the-loop simulation, often this type of simulation is considered human-out-of-the loop simulation. In this particular case a computer model’s behavior is modified according to a set of initial parameters. The results of the model differ from a true human-in-the-loop simulation because the results can easily be replicated time and time again by simply providing identical parameters.
 See also
- "DoD Modeling and Simulation (M&S) Glossary", DoD 5000.59-M, DoD, January 1998 
- Karwowski, Waldemar, "International encyclopedia of ergonomics and human factors", ISBN 0-415-30430-X, 9780415304306, CRC Press, 2006 
- Simulation - Wikipedia, the free encyclopedia. Wikipedia, the free encyclopedia. Retrieved July 19, 2010, from http://en.wikipedia.org/wiki/Simulation
- Sollenberger, R. (2005). Human-in-the-Loop Simulation Evaluating the Collocation of the User Request Evaluation Tool. U.S. Department of Transportation Federal Aviation Administration, 1. Retrieved July 19, 2010, from http://hf.tc.faa.gov/technotes/dot-faa-ct-tn04-28.pdf
- Human-in-the-loop simulation: The right tool for port design. (2007, Spring). Port Technology International, 32, 1-2. Retrieved July 19, 2010, from http://www.marinesafety.com/research/documents/HumanintheloopSimulationasPublishedinPortTechnologyInternationalIssue32.pdf