Human Proteome Folding Project

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The Human Proteome Folding Project (HPF) is a collaborative effort between New York University (Bonneau Lab), the Institute for Systems Biology (ISB) and the University of Washington (Baker Lab), using the Rosetta software developed by the Rosetta Commons.

As of January 2007, the HPF project is currently in Phase 2, which is running exclusively on the World Community Grid. Phase 1 ran on two distributed computing grids: the World Community Grid, an IBM philanthropic initiative, and on United Devices'

The Institute for Systems Biology designed the Human Proteome Folding project for World Community Grid and will use the results within its larger research efforts.

WCG screensaver, Human Proteome Folding Project Phase2, running under UD client software

Current project status[edit]

HPF Phase 1 applied Rosetta v4.2x software on the human genome and 89 others, starting in November 2004. Phase 1 ended in July 2006. HPF Phase 2 (HPF2) applies the Rosetta v4.8x software in higher resolution, "full atom refinement" mode, concentrating on cancer biomarkers (proteins found at dramatically increased levels in cancer tissues), human secreted proteins and malaria.


Malmström, Lars; Riffle, Michael; Strauss, Charlie E. M.; Chivian, Dylan; Davis, Trisha N.; Baker, David; Baker, D (2007), "Superfamily Assignments for the Yeast Proteome through Integration of Structure Prediction with the Gene Ontology", PLoS Biology 5 (4): e76, doi:10.1371/journal.pbio.0050076, PMC 1828141, PMID 17373854 

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