Humanist minuscule is a handwriting or style of script that was invented in secular circles in Italy, at the beginning of the fifteenth century. "Few periods in Western history have produced writing of such great beauty", observes the art historian Millard Meiss. The new hand was based on Carolingian minuscule, which Renaissance humanists, obsessed with the revival of Antiquity and their role as its inheritors, took to be ancient Roman: "when they handled manuscript books copied by eleventh- and twelfth-century scribes, quattrocento literati thought they were looking at texts that came right out of the bookshops of ancient Rome".
The humanistic term litterae antiquae (the "ancient letters") applied to this hand was an inheritance from the fourteenth century, where the phrase had been opposed to litterae modernae, "modern letters", in other words, the Gothic script.
The humanist minuscule was connected to the humanistic content of the texts for which it was the appropriate vehicle. By contrast, 15th-century texts of professional interest in the fields of law, medicine, and the old thomistic philosophy still being taught in the universities, were circulated in the gothic hand, whereas vernacular literature had its own, separate, distinctive traditions. "A humanist manuscript was intended to suggest its contents by its look," Martin Davies has noted: "old wine in new bottles, or the very latest vintage in stylish new dress". With the diffusion of humanist manuscripts produced in the highly organized commercial scriptoria of Quattrocento Italy, the Italian humanist script reached the rest of Europe, a very important aspect which has not yet been fully explored.
Petrarchan reform 
In Petrarch's compact book hand, the wider leading and reduced compression and round curves are early manifestations of the reaction against the crabbed Gothic secretarial minuscule we know today as "blackletter"; Petrarch was one of the few medieval authors to have written at any length on the handwriting of his time; in his essay on the subject, La scrittura he criticized the current scholastic hand, with its laboured strokes (artificiosis litterarum tractibus) and exuberant (luxurians) letter-forms amusing the eye from a distance, but fatiguing on closer exposure, as if written for other purpose than to be read. For Petrarch the gothic hand violated three principles: writing, he said, should be simple (castigata), clear (clara) and orthographically correct. Boccaccio was a great admirer of Petrarch; from Boccaccio's immediate circle this post-Petrarchan "semi-gothic" revised hand spread to literati in Florence, Lombardy and the Veneto.
Poggio Bracciolini 
A more thorough reform of handwriting than the Petrarchan compromise was in the offing. The generator of the new style (illustration) was Poggio Bracciolini, a tireless pursuer of ancient manuscripts, who developed the new humanist script in the first decade of the 15th century. The Florentine bookseller Vespasiano da Bisticci recalled later in the century that Poggio had been a very fine calligrapher of lettera antica and had transcribed texts to support himself— presumably, as Martin Davies points out— before he went to Rome in 1403 to begin his career in the papal curia. Berthold Ullman identifies the watershed moment in the development of the new humanistic hand as the youthful Poggio's transcription of Cicero's Epistles to Atticus. By the time the Medici library was catalogued in 1418, almost half the manuscripts were noted as in the lettera antica. The new script was embraced and developed by the Florentine humanists and educators Niccolò de' Niccoli and Coluccio Salutati.
Niccoli's cursive and roman typeface 
The neat sloping humanist cursive invented by the Florentine humanist Niccolò de' Niccoli in the 1420s and disseminated through his scholars is usually characterized as essentially a rapid version of the same script. Rhiannon Daniels writes, however, "This was not humanistic bookhand written cursively, but a running script written with a very fine pen; a modification of contemporary gothic chancery script influenced by humanistic bookhand; hence it is sometimes known as cancelleresca all'antica". In the late fifteenth century a "chancery italic" script was developed by humanists in Rome from the cursive humanist minuscule. Calligraphic forms of chancery italic were popularized by the famous Roman writing master Ludovico Arrighi in the early sixteenth century.
In the history of Western typography the humanist minuscule played a prominent part as a model for the typesetter's roman typeface, as it was standardized by Aldus Manutius, who introduced his revolutionary italic typeface based on the chancery cursive in Venice, 1501, and was practised by designer-printers Nicolas Jenson and Francesco Griffo; roman type has helped establish the remarkable resistance to change of the modern Latin alphabet.
- D. Thomas, "What is the origin of the scrittura humanistica?", Bibliofilia 53 (1951:1-10).
- Meiss, "Towards a more comprehensive Renaissance palaeography", The Art Bulletin 42 (1960:1).
- Elizabeth Eisenstein, The Printing Revolution in Early Modern Europe, 2nd ed. (Cambridge University Press) 2006:134. Knowledge of ancient scripts sometimes went backwards before it went forwards; the late medieval Reims Gospel, an Old Church Slavonic manuscript using Glagolithic and Cyrillic scripts, was thought to have been scribed by Saint Jerome himself, and in the late 16th century incorporated into the coronation ceremony of French kings, who took the oath of the Order of the Holy Spirit by touching the book.
- Martin Davies, "Humanism in script and print", in Jill Kraye, ed. The Cambridge Companion to Renaissance Humanism, 1996:note 3 p. 60.
- Davies in Kraye (ed.) 1996:51.
- P.O. Kristeller, "The European Diffusion of Italian Humanism", Italica 39, 1962.
- Petrarch, La scrittura, discussed by Armando Petrucci, La scrittura di Francesco Petrarca (Vatican City) 1967.
- Petrarch, La scrittura, noted in Albert Derolez, "The script reform of Petrarch: an illusion?" in John Haines, Randall Rosenfeld, eds. Music and Medieval Manuscripts: paleography and performance 2006:5f; Derolez discusses the degree of Petrarch's often alluded-to reform.
- Mirella Ferrari "La 'littera antiqua' a Milan, 1417-1439" in Johanne Autenrieth, ed. Renaissance- und Humanistenhandschriften, (Munich: Oldenbourg,) 1988:21-29.
- Rhiannon Daniels, Boccaccio and the book: production and reading in Italy 1340-1520, 2009:28.
- Davies, in Kraye (ed.) 1996:51.
- Ullman, The Origin and Development of Humanistic Script (Rome) 1960.
- Stanley Morison, "Early humanistic script and the first roman type", reprinted in his Selected Essays on the History of Letter-Forms in Manuscript and Print, ed. by David McKitterick, 2 vols. 1981:206-29.
- cancelleresca all'antica: "chancery script in the ancient manner"; Daniels 2009:29.
- "Rome Reborn: The Vatican Library & Renaissance Culture"
- S. Morison, "Early humanistic script and the first roman type", The Library 24 (1943:1-291; Lane Wilkinson (University of Tennessee at Chattanooga), "The Humanistic minuscule and the advent of Roman type" (online text in pdf format).