More than three hours long, Hurlyburly focuses on the intersecting lives of several low- to mid-level Hollywood players in the 1980s. Fueled by massive amounts of drugs, they attempt to find some meaning in their isolated, empty lives by engaging in endless discussions laced with misogyny. The central character Eddie's oft-repeated apathetic question "How does it pertain to me?" sums up his spiritual agony as he heads for catharsis.
- First Witch: "When shall we three meet again / In thunder, lightning, or in rain?"
- Second Witch: "When the hurlyburly's done, / When the battle's lost and won."
The play's first staging was produced by the Goodman Theatre in Chicago. The Broadway production, directed by Mike Nichols, opened on August 7, 1984 at the Ethel Barrymore Theatre, where it ran for 343 performances. The original cast included William Hurt, Christopher Walken, Harvey Keitel, Jerry Stiller, Judith Ivey, Sigourney Weaver, and Cynthia Nixon.
Nixon was performing in The Real Thing at the same time. (The timing of her entrance and exit in each play allowed her to run back and forth between the two theatres, located two blocks from each other.) Replacements later in the run included Danny Aiello, Susan Anton, Christine Baranski, Frank Langella, Ron Silver, John Rubinstein and Candice Bergen.
A 2005 Off-Broadway revival was produced by The New Group, and starred Ethan Hawke, Josh Hamilton, Bobby Cannavale, Parker Posey, Wallace Shawn, Halley Wegryn Gross, and Catherine Kellner. Elizabeth Berkley took over from Catherine Kellner and received much praise, with Charles Isherwood of The New York Times even going as far as apologizing to her for his past criticisms of her ability, stating that the fact she held "her own among this skilled company of scene-stealers is a testament to how much her talent has grown".  The production received critical acclaim and garnered a Drama Desk Award nomination for Outstanding Revival of a Play.
Awards and nominations
- Tony Award for Best Play (nominee)
- Drama Desk Award for Outstanding Revival of a Play (2005 production by The New Group, nominee)
Rabe wrote the screenplay for a 1998 film version directed by Anthony Drazan. He condensed the action into two hours and updated the setting from the mid-1980s to the late 1990s. The cast included Sean Penn, Kevin Spacey, Chazz Palminteri, Robin Wright Penn, Garry Shandling, Anna Paquin, and Meg Ryan. Penn's performance won him the Volpi Cup and Drazan was nominated for the Golden Lion at the Venice Film Festival. Penn also was nominated Best Male Lead at the Independent Spirit Awards.
- Rich, Frank (22 June 1984). "THEATER: 'HURLYBURLY'". The New York Times. Retrieved 31 March 2010.
- McKinley, Jesse (22 February 2005). "'Hurlyburly' Will Move, Bypassing Broadway". The New York Times. Retrieved 31 March 2010.
- Isherwood, Charles. "The Redemption of Elizabeth Berkley". The New York Times, June 19, 2005. Accessed 13 May 2009.
- Hernandez, Ernio (19 Mar 2005). "Hiatus: Hurlyburly Shuts Down Production Off-Broadway Before Moving to New Location". Playbill. Retrieved 31 March 2010.
- Simonson, Robert (28 Apr 2005). "Drama Desk Nominations Announced April 28". Playbill. Retrieved 31 March 2010.
- "NYC Group Production". Retrieved May 27, 2010.