Hurthle cell

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Hürthle cell
Classification and external resources
Hurthle cell neoplasm.jpg
Micrograph showing Hürthle cells in a Hürthle cell neoplasm. Pap stain.
ICD-10 C73.9
ICD-O: 8290/0
DiseasesDB 31956
eMedicine med/1045
MeSH D018249

A Hürthle cell is a cell in the thyroid that is often associated with Hashimoto's thyroiditis[1] as well as follicular thyroid cancer.

Histology[edit]

Hürthle cells are characterized as enlarged epithelial cells with abundant eosinophilic granular cytoplasm as a result of altered mitochondria.[2] They generally stain pink and are prominently found in histological sections of thyroid glands affected with Hashimoto's.

Clinical significance[edit]

A Hürthle cell adenoma is a type of thyroid benign tumor[3] that, in rare cases, has the potential to become malignant[4] and metastasize (Hürthle cell carcinoma). Hürthle cells are also found in Hashimoto's thyroiditis and toxic and nontoxic nodular goiter. Hürthle cells are hypothesized to be of follicular epithelial origin.

Eponym[edit]

It is named for Karl Hürthle.[5][6]

See also[edit]

References[edit]

  1. ^ "Endocrine Pathology". Retrieved 2009-05-07. 
  2. ^ Aytug, Serhat (June 13, 2006). "Hurthle Cell Carcinoma". eMedicine. 
  3. ^ "Hürthle cell tumor" at Dorland's Medical Dictionary
  4. ^ Qian L, Pucci R, Castro CY, Eltorky MA (October 2004). "Renal cell carcinoma metastatic to Hürthle cell adenoma of thyroid". Ann Diagn Pathol 8 (5): 305–8. doi:10.1016/j.anndiagpath.2004.07.011. PMID 15494939. 
  5. ^ synd/2742 at Who Named It?
  6. ^ M. Askanazy. Pathologisch-anatomische Beiträge zur Kenntniss des morbus basedowii, insbesondere uber die dabei auftretende Muskelerkrankkung. Deutsches Archiv für klinische Medicin, Leipzig, 1898, 61:118-186.

External links[edit]