Hydroflumethiazide

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Hydroflumethiazide
Hydroflumethiazide.svg
Systematic (IUPAC) name
1,1-Dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide
Clinical data
AHFS/Drugs.com Micromedex Detailed Consumer Information
Identifiers
135-09-1 YesY
C03AA02
PubChem CID 3647
DrugBank DB00774 YesY
ChemSpider 3521 YesY
UNII 501CFL162R YesY
KEGG D00654 YesY
ChEMBL CHEMBL1763 YesY
Chemical data
Formula C8H8F3N3O4S2
331.29 g/mol
 YesY (what is this?)  (verify)

Hydroflumethiazide (or Saluron) is a diuretic.

Synthesis[edit]

Hydroflumethiazide synthesis:[1][2][3] Numerous patents, e.g., Lund et al., U.S. Patent 3,254,076 (1966 to Lövens Kemiske Fabrik).

See also[edit]

References[edit]

  1. ^ Holdrege, C. T.; Babel, R. B.; Cheney, L. C. (1959). "Synthesis of Trifluoromethylated Compounds Possessing Diuretic Activity1". Journal of the American Chemical Society 81 (18): 4807. doi:10.1021/ja01527a015.  edit
  2. ^ Close, W. J.; Swett, L. R.; Brady, L. E.; Short, J. H.; Vernsten, M. (1960). "Synthesis of Potential Diuretic Agents. I. Derivatives of 7-Sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-Dioxide". Journal of the American Chemical Society 82 (5): 1132. doi:10.1021/ja01490a028.  edit
  3. ^ Novello, F. C.; Bell, S. C.; Abrams, E. L. A.; Ziegler, C.; Sprague, J. M. (1960). "Diuretics: 1,2,4-Benzothiadiazine-1,1-dioxides". The Journal of Organic Chemistry 25 (6): 970. doi:10.1021/jo01076a028.  edit