Hydroxyquinol 1,2-dioxygenase

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hydroxyquinol 1,2-dioxygenase
Identifiers
EC number 1.13.11.37
CAS number 91847-14-2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a hydroxyquinol 1,2-dioxygenase (EC 1.13.11.37) is an enzyme that catalyzes the chemical reaction

benzene-1,2,4-triol + O2 \rightleftharpoons 3-hydroxy-cis,cis-muconate

Thus, the two substrates of this enzyme are benzene-1,2,4-triol (hydroxyquinol) and O2, whereas its product is 3-hydroxy-cis,cis-muconate.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O2 as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2. The systematic name of this enzyme class is benzene-1,2,4-triol:oxygen 1,2-oxidoreductase (decyclizing). This enzyme is also called hydroxyquinol dioxygenase. This enzyme participates in benzoate degradation via hydroxylation and 1,4-dichlorobenzene degradation. It employs one cofactor, iron.

Structural studies[edit]

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1TMX.

References[edit]