Hygrine

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Hygrine
Chemical structure of hygrine
Ball-and-stick model of hygrine molecule
Names
IUPAC name
(R)-1-(1-Methylpyrrolidin-2-yl)-propan-2-one
Identifiers
496-49-1 YesY
ChEBI CHEBI:46750 YesY
ChemSpider 389762 YesY
Jmol-3D images Image
KEGG C06179 YesY
PubChem 440933
Properties
C8H15NO
Molar mass 141.21 g/mol
Boiling point 193 to 195 °C (379 to 383 °F; 466 to 468 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 YesY verify (what isYesY/N?)
Infobox references

Hygrine is a pyrrolidine alkaloid, found mainly in coca leaves (0.2%). It was first isolated by Carl Liebermann in 1889 (along with a related compound cuscohygrine) as an alkaloid accompanying cocaine in coca. Hygrine is extracted as a thick yellow oil, having a pungent taste and odor.

See also[edit]

hygrine was detected by many identifcal tests before knowing it's stracture. 1-it gives with nitrus acid HNO2 nigative results so they know that the nitrogen in compound exist as tertiary group. compound + HNO2 ---> -ve . 2-it gives with benzene sulphonyl chloride -ve results doesn't give a benzyl drvative . compound + phSO2Cl ---> -ve . 3-it gives with hydrogen iodid compound + HI ---> -(CH2)2NCH3 so that is mean it's contain NCH3 group. 4-it gives with dinitrobenzophenone (DNP) . compound + DNP ---> yelleow crystal so that mean it's contain cabonyl group. 5- it doesnot reduce fihling agent .

it prepared by (1,3 di bromoprobane + diethylacetate )+ then addition of Br2 under going reaction (bi nuclophilc substetution reaction SN2) + followed by addition of (methyl amine) (NH2CH3) -----> it gives hygirne.

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