|Molar mass||141.21 g/mol|
|Boiling point||193 to 195 °C (379 to 383 °F; 466 to 468 K)|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|what is: / ?)(|
Hygrine is a pyrrolidine alkaloid, found mainly in coca leaves (0.2%). It was first isolated by Carl Liebermann in 1889 (along with a related compound cuscohygrine) as an alkaloid accompanying cocaine in coca. Hygrine is extracted as a thick yellow oil, having a pungent taste and odor.
hygrine was detected by many identifcal tests before knowing it's stracture. 1-it gives with nitrus acid HNO2 nigative results so they know that the nitrogen in compound exist as tertiary group. compound + HNO2 ---> -ve . 2-it gives with benzene sulphonyl chloride -ve results doesn't give a benzyl drvative . compound + phSO2Cl ---> -ve . 3-it gives with hydrogen iodid compound + HI ---> -(CH2)2NCH3 so that is mean it's contain NCH3 group. 4-it gives with dinitrobenzophenone (DNP) . compound + DNP ---> yelleow crystal so that mean it's contain cabonyl group. 5- it doesnot reduce fihling agent .
it prepared by (1,3 di bromoprobane + diethylacetate )+ then addition of Br2 under going reaction (bi nuclophilc substetution reaction SN2) + followed by addition of (methyl amine) (NH2CH3) -----> it gives hygirne.
- Dr. Ame Pictet (1904). The Vegetable Alkaloids. With particular reference to their chemical constitution. London: Chapman & Hall.
- "Hygrine". Webster's Revised Unabridged Dictionary (? ed.). 1913.
- "USDA, ARS, National Genetic Resources Program. Phytochemical and Ethnobotanical Databases.[Online Database] National Germplasm Resources Laboratory, Beltsville, Maryland.". Retrieved July 15, 2005.