Hypermagnesemia
| Hypermagnesemia | |
|---|---|
| Classification and external resources | |
 Magnesium |
|
| ICD-10 | E83.4 |
| ICD-9 | 275.2 |
| DiseasesDB | 6259 |
| eMedicine | med/3383 emerg/262 ped/1080 |
Hypermagnesemia is an electrolyte disturbance in which there is an abnormally elevated level of magnesium in the blood.[1] Usually this results in excess of magnesium in the body.
Hypermagnesemia occurs rarely because the kidney is very effective in excreting excess magnesium. It usually develops only in people with kidney failure who are given magnesium salts or who take drugs that contain magnesium (e.g. some antacids and laxatives). It is usually concurrent with hypocalcemia and/or hyperkalemia.
Contents |
[edit] Metabolism
For a detailed description of magnesium homeostasis and metabolism see hypomagnesemia.
[edit] Symptoms
- Weakness, nausea and vomiting
- Impaired breathing
- Hypotension
- Hypocalcemia
- Arrhythmia and Asystole
Arrhythmia and asystole are possible cardiac complications of hypermagnesemia. Magnesium acts as physiologic calcium blocker, which results in electrical conduction abnormalities.
Clinical consequences related to serum concentration:
- 4.0 mEq/l hyporeflexia
- >5.0 mEq/l Prolonged atrioventricular conduction
- >10.0 mEq/l Complete heart block
- >13.0 mEq/l Cardiac arrest
Note that the therapeutic range for the prevention of the pre-eclampsic uterine contractions is: 4.0-7.0 mEq/L.[2] As per Lu and Nightingale,[3] serum Mg2+ concentrations associated with maternal toxicity (also neonate depression - hypotonia and low Apgar scores) are:
- 7.0-10.0 mEq/L - loss of patellar reflex
- 10.0-13.0 mEq/L - respiratory depression
- 15.0-25.0 mEq/L - altered atrioventricular conduction and (further) complete heart block
- >25.0 mEq/L - cardiac arrest
[edit] Causes
Since magnesium is excreted through the kidneys, renal failure (as a result of hypermagnesemia) most often occurs due to prolonged over supplementation or long term use of magnesium containing medications or laxatives.
[edit] Predisposing conditions
- Hemolysis, magnesium concentration in erythrocytes is approximately three times greater than in serum, therefore hemolysis can increase plasma magnesium. Hypermagnesemia is expected only in massive hemolysis.
- Renal insufficiency, excretion of magnesium becomes impaired when creatinine clearance falls below 30 ml/min. However, hypermagnesemia is not a prominent feature of renal insufficiency unless magnesium intake is increased.
- Other conditions that can predispose to mild hypermagnesemia are diabetic ketoacidosis, adrenal insufficiency, hyperparathyroidism and lithium intoxication.
[edit] Therapy
Prevention of hypermagnesemia usually is possible. In mild cases, withdrawing magnesium supplementation is often sufficient. In more severe cases the following treatments are used:
- Intravenous calcium gluconate, because the actions of magnesium in neuromuscular and cardiac function are antagonized by calcium.
Definitive treatment of hypermagnesemia requires increasing renal magnesium excretion through:
- Intravenous diuretics, in the presence of normal renal function
- Dialysis, when kidney function is impaired and the patient is symptomatic from hypermagnesemia
[edit] References
- ^ "hypermagnesemia" at Dorland's Medical Dictionary
- ^ Pritchard JA. The use of the magnesium ion in the management of eclamptogenic toxemias. Surg Gynecol Obstet. 1955; 100:131–140
- ^ Lu JF,Nightingale CH. Magnesium sulfate in eclampsia and pre-eclampsia. Clin Pharmacokinet. 2000; 38:305–314
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