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Section through the embryo. (Hypoblast visible but not labeled.)
Latin hypoblastus
Days 8
Precursor inner cell mass
Gives rise to endoderm
Code TE E6.
Anatomical terminology

The hypoblast is a tissue type that forms from the inner cell mass.[1] It lies beneath the epiblast and consists of small cuboidal cells.[2]

Extraembryonic endoderm (including Yolk sac) is derived from the epiblast which displaces the hypoblast cells. The absence of hypoblast results in multiple primitive streaks in chicken embryos.[3] The formation of the primitive streak, through which gastrulation occurs, is induced by Koller's sickle.[4]


  1. ^ UNSW Embryology- Glossary H
  2. ^ Moore, K. L., and Persaud, T. V. N. (2003). The Developing Human: Clinically Oriented Embryology. 7th Ed. Philadelphia: Elsevier. ISBN 0-7216-9412-8.
  3. ^ Perea-Gomez A, Vella FD, Shawlot W, Oulad-Abdelghani M, Chazaud C, Meno C, Pfister V, Chen L, Robertson E, Hamada H, Behringer RR, Ang SL. (2002). "Nodal antagonists in the anterior visceral endoderm prevent the formation of multiple primitive streaks". Dev Cell. 3 (5): 745–56. doi:10.1016/S1534-5807(02)00321-0. PMID 12431380. 
  4. ^ Gilbert SF. Developmental Biology. 10th edition. Sunderland (MA): Sinauer Associates; 2014. Early Development in Birds. Print

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