Hypogammaglobulinemia is a type of immune disorder characterized by a reduction in all types of gamma globulins.[1]
Hypogammaglobulinemia is a characteristic of common variable immunodeficiency.[2]
[edit] Terminology
"Hypogammaglobulinemia" is distinguished from dysgammaglobulinemia, which is a reduction in some types of gamma globulins, but not others.[3][4]
"Hypogammaglobulinemia" is largely synonymous with "agammaglobulinemia". When this term is used (as in "X-linked agammaglobulinemia") it implies that gamma globulins are not merely reduced, but completely absent. Modern assays have allowed most agammaglobulinemias to be more precisely defined as hypogammaglobulinemias,[5] but the distinction is not usually clinically relevant.
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| Globin |
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| Globulin |
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| Serpin |
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see also globular proteins, globins, antibodies, serpins
B structural (perx, skel, cili, mito, nucl, sclr) · DNA/RNA/protein synthesis (drep, trfc, tscr, tltn) · membrane (icha, slcr, atpa, abct, othr) · transduction (iter, csrc, itra), trfk
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G protein-coupled receptor
(including hormone) |
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Class A
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Class B
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Class C
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Class F
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Enzyme-linked receptor
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growth factor) |
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| JAK-STAT |
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| TNF receptor |
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| Lipid receptor |
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| Other/ungrouped |
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see also cell surface receptors
B structural (perx, skel, cili, mito, nucl, sclr) · DNA/RNA/protein synthesis (drep, trfc, tscr, tltn) · membrane (icha, slcr, atpa, abct, othr) · transduction (iter, csrc, itra), trfk
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