Hypoprothrombinemia

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Hypoprothrombinemia
Classification and external resources
ICD-10 D68.2
ICD-9 286.3, 776.3
eMedicine ped/1133
MeSH D007020

Hypoprothrombinemia is a blood disorder in which a deficiency of prothrombin (Factor II) results in impaired blood clotting, leading to an increased physiological risk for bleeding, especially in the gastrointestinal system, cranial vault, and superficial integumentary system.

Causes[edit]

Hypoprothrombinemia can be the result of a genetic defect, may be acquired as the result of another disease process, or may be an adverse effect of medication. For example, 5-10% of patients with systemic lupus erythematosus exhibit acquired hypoprothrombinemia due to the presence of autoantibodies which bind to prothrombin and remove it from the bloodstream (lupus anticoagulant-hypoprothrombinaemia syndrome).[1]

It may also be a rare adverse effect to Rocephin.[2]

Treatment[edit]

Hypoprothrombinemia can be treated with periodic infusions of purified prothrombin complexes.[3]

References[edit]

  1. ^ Bajaj S, Rapaport S, Fierer D, Herbst K, Schwartz D (1983). "A mechanism for the hypoprothrombinemia of the acquired hypoprothrombinemia-lupus anticoagulant syndrome.". Blood 61 (4): 684–92. PMID 6403077. 
  2. ^ [ http://www.gene.com/download/pdf/rocephin_prescribing.pdf Rocephin proscribing information]. Accessed October 24, 2013.
  3. ^ Lechler E (1999). "Use of prothrombin complex concentrates for prophylaxis and treatment of bleeding episodes in patients with hereditary deficiency of prothrombin, factor VII, factor X, protein C protein S, or protein Z.". Thromb Res 95 (4 Suppl 1): S39–50. doi:10.1016/S0049-3848(99)00083-3. PMID 10499908.