Normal respiration is driven mostly by the levels of carbon dioxide in the arteries, which are detected indirectly by central chemoreceptors when carbon dioxide crosses the blood brain barrier, forming detectable Hydrogen ions, and directly by peripheral chemoreceptors, and very little by the oxygen levels. An increase in carbon dioxide will cause chemoreceptor reflexes to trigger an increase in ventilation. Hypoxic drive accounts normally for 10% of the total drive to breathe. This increases as the PaO2 goes to 70 torr and below, while hypoxic drive is no longer active when PaO2 exceeds 170 torr. The hypoxic drive is so weak that unconsciousness will develop before respiratory distress is noted and is therefore a risk for pilots flying at high altitudes. For this reason, supplemental oxygen is required by Federal Aviation Regulations for pilots flying above about 12,500 feet altitude in unpressurized airplanes.
In the past, it was believed that in cases where there are chronically high carbon dioxide levels in the blood such as in COPD patients, the body will begin to rely more on the oxygen receptors and less on the carbon dioxide receptors. And that in this case, when there is an increase in oxygen levels the body will decrease the rate of respiration.
Recent studies have proven that COPD patients who have chronically compensated elevated CO2 levels (known as "CO2 Retainers") are not in fact dependent on hypoxic drive to breathe. However, when in respiratory failure and put on high inspired oxygen, the CO2 in their blood may increase via three mechanisms, namely the Haldane Effect, the Ventilation/Perfusion mismatch (where the regional pulmonary hypoxic vasoconstriction is released) and by the removal or reduction of the hypoxic drive itself.
- FAR 91.211
- Kim, V; Benditt JO; Wise RA; Sharafkhaneh A (2008). "Oxygen therapy in chronic obstructive pulmonary disease". Proceedings of the American Thoracic Society 5 (4): 513–8. doi:10.1513/pats.200708-124ET. PMC 2645328. PMID 18453364.
- Lumb, AB (2000). Nunn's Applied Respiratory Physiology (5th ed.). Butterworth Heinemann. p. 533. ISBN 0-7506-3107-4.
- Brady. Anatomy and Physiology for Emergency Care