I-384 serves as the main interstate transportation artery for southern Manchester, beginning right before the East Hartford/Manchester town line and having four of its six exits within southern Manchester. The two major stops off the highway include the Spencer Street commercial shopping district located at Exit 1 and the Main Street/Downtown Manchester area off Exit 3.
The highway is 8 lanes wide west of Route 83, 6 lanes wide to Route 85, and four lanes wide for the rest of the highway's duration.
Since May 31, 1996, the segment of Interstate 384 "running from the junction of Interstate Route 84 in Manchester in a general easterly direction to Route 6 in Bolton" has been officially known as the State Trooper Russell A. Bagshaw Highway, in memory of a Connecticut State Police trooper who was killed in the line of duty. 
Prior to 1984, Interstate 384 was designated Interstate 84. During that time, current Interstate 84 east of the East Hartford junction was Interstate 86. Originally, the freeway was supposed to end in Johnston, Rhode Island at the Interstate 95-Interstate 195 connector (now the Route 6-10 Connector). The freeway was built to Bolton where it abruptly ends at Route 6. A freeway was to be built towards the present Route 6 bypass at Willimantic, Connecticut. From there, the freeway was to be built towards Interstate 395 in Killingly. After that a freeway was built towards the Rhode Island border at Route 6. There the freeway was to be built parallel to Route 6 towards Johnston. In 1982, Rhode Island canceled their plans because of community backlash and possible changes to the Scituate Reservoir. In 1986, Connecticut canceled their plans and changed I-86 back to I-84 and I-84 was renumbered I-384. State legislators have proposed to extend I-384 from Bolton to Willimantic where the Route 6 bypass is completed. if completed, I-384 would bypass Route 6. Route 6 from Bolton to Willimantic is known as "Suicide 6" because of all the sharp turns and intersections. On average, at least two people/year die on the "Suicide 6" stretch. If on schedule, this section of I-384 is supposed to be completed by 2025.