ICA1

Islet cell autoantigen 1, 69kDa
Identifiers
Symbols	ICA1; ICA69; ICAp69
External IDs	OMIM: 147625 MGI: 96391 HomoloGene: 7777 GeneCards: ICA1 Gene
Gene Ontology Molecular function • molecular_function • protein binding • protein domain specific binding Cellular component • Golgi membrane • nucleus • nucleolus • cytoplasm • Golgi apparatus • Golgi stack • cytosol • membrane • cell junction • dendrite • transport vesicle membrane • secretory granule membrane • synaptic vesicle membrane • cytoplasmic vesicle • synapse • perinuclear region of cytoplasm Biological process • neurotransmitter transport • regulation of protein homodimerization activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3382	15893
Ensembl	ENSG00000003147	ENSMUSG00000062995
UniProt	Q05084	P97411
RefSeq (mRNA)	NM_001136020.1	NM_010492.3
RefSeq (protein)	NP_001129492.1	NP_034622.3
Location (UCSC)	Chr 7: 8.15 – 8.3 Mb	Chr 6: 8.58 – 8.73 Mb
PubMed search	[1]	[2]

Islet cell autoantigen 1 is a protein that in humans is encoded by the ICA1 gene.

This gene encodes a protein with an arfaptin homology domain that is found both in the cytosol and as membrane-bound form on the Golgi complex and immature secretory granules. This protein is believed to be an autoantigen in insulin-dependent diabetes mellitus and primary Sjogren's syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

Further reading

• Nepom GT (1996). "Glutamic acid decarboxylase and other autoantigens in IDDM". Curr. Opin. Immunol. 7 (6): 825–30. doi:10.1016/0952-7915(95)80055-7. PMID 8679127. 
• Thai AC, Ng WY, Lui KF, Cheah JS (1996). "Islet cell and thyroid autoimmunity in Chinese patients with IDDM". Diabetes Care 18 (4): 586–7. PMID 7497880. 
• Martin S, Kardorf J, Schulte B et al (1995). "Autoantibodies to the islet antigen ICA69 occur in IDDM and in rheumatoid arthritis". Diabetologia 38 (3): 351–5. doi:10.1007/BF00400641. PMID 7758883. 
• Miyazaki I, Cheung RK, Gaedigk R et al (1995). "T cell activation and anergy to islet cell antigen in type I diabetes". J. Immunol. 154 (3): 1461–9. PMID 7822811. 
• Lampasona V, Ferrari M, Bosi E et al (1995). "Sera from patients with IDDM and healthy individuals have antibodies to ICA69 on western blots but do not immunoprecipitate liquid phase antigen". J. Autoimmun. 7 (5): 665–74. doi:10.1006/jaut.1994.1051. PMID 7840858. 
• Gaedigk R, Duncan AM, Miyazaki I et al (1994). "ICA1 encoding p69, a protein linked to the development of type 1 diabetes, maps to human chromosome 7p22". Cytogenet. Cell Genet. 66 (4): 274–6. doi:10.1159/000133711. PMID 8162706. 
• Pietropaolo M, Castaño L, Babu S et al (1993). "Islet cell autoantigen 69 kD (ICA69). Molecular cloning and characterization of a novel diabetes-associated autoantigen". J. Clin. Invest. 92 (1): 359–71. doi:10.1172/JCI116574. PMC 293615. PMID 8326004. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=293615. 
• Karges W, Pietropaolo M, Ackerley CA, Dosch HM (1996). "Gene expression of islet cell antigen p69 in human, mouse, and rat". Diabetes 45 (4): 513–21. doi:10.2337/diabetes.45.4.513. PMID 8603775. 
• Martin S, Lampasona V, Dosch M, Pietropaolo M (1996). "Islet cell autoantigen 69 antibodies in IDDM". Diabetologia 39 (6): 747. doi:10.1007/BF00418550. PMID 8781774. 
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
• Gaedigk R, Karges W, Hui MF et al (1997). "Genomic organization and transcript analysis of ICAp69, a target antigen in diabetic autoimmunity". Genomics 38 (3): 382–91. doi:10.1006/geno.1996.0641. PMID 8975715. 
• Stassi G, Schloot N, Pietropaolo M (1997). "Islet cell autoantigen 69 kDa (ICA69) is preferentially expressed in the human islets of Langerhans than exocrine pancreas". Diabetologia 40 (1): 120–2. PMID 9028728. 
• Rønningen KS, Atrazhev A, Luo L et al (1998). "Anti-BSA antibodies do not cross-react with the 69-kDa islet cell autoantigen ICA69". J. Autoimmun. 11 (3): 223–31. doi:10.1006/jaut.1998.0199. PMID 9693970. 
• Kerokoski P, Ilonen J, Gaedigk R et al (1999). "Production of the islet cell antigen ICA69 (p69) with baculovirus expression system: analysis with a solid-phase time-resolved fluorescence method of sera from patients with IDDM and rheumatoid arthritis". Autoimmunity 29 (4): 281–9. doi:10.3109/08916939908994748. PMID 10433084. 
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310948. 
• Winer S, Astsaturov I, Cheung R et al (2002). "Primary Sjögren's syndrome and deficiency of ICA69". Lancet 360 (9339): 1063–9. doi:10.1016/S0140-6736(02)11144-5. PMID 12383988. 
• Friday RP, Pietropaolo SL, Profozich J et al (2003). "Alternative core promoters regulate tissue-specific transcription from the autoimmune diabetes-related ICA1 (ICA69) gene locus". J. Biol. Chem. 278 (2): 853–63. doi:10.1074/jbc.M210175200. PMID 12409289.