ICAM3

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Intercellular adhesion molecule 3
Protein ICAM3 PDB 1t0p.png
PDB rendering based on 1t0p.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ICAM3 ; CD50; CDW50; ICAM-R
External IDs OMIM146631 HomoloGene88479 GeneCards: ICAM3 Gene
RNA expression pattern
PBB GE ICAM3 204949 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3385 n/a
Ensembl ENSG00000076662 n/a
UniProt P32942 n/a
RefSeq (mRNA) NM_002162 n/a
RefSeq (protein) NP_002153 n/a
Location (UCSC) Chr 19:
10.44 – 10.45 Mb
n/a
PubMed search [1] n/a

Intercellular adhesion molecule 3 (ICAM3) also known as CD50 (Cluster of Differentiation 50), is a human gene.

The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response.[1] It functions not only as an adhesion molecule, but also as a potent signalling molecule.[2]

Interactions[edit]

ICAM3 has been shown to interact with EZR[3][4] and Moesin.[4][5]

See also[edit]

References[edit]

  1. ^ de Fougerolles AR, Springer TA. (1992). "Intercellular adhesion molecule 3, a third adhesion counter-receptor for lymphocyte function-associated molecule 1 on resting lymphocytes". J Exp Med 175: 185. PMID 1730916. 
  2. ^ "Entrez Gene: ICAM3 intercellular adhesion molecule 3". 
  3. ^ Heiska, L; Alfthan K; Grönholm M; Vilja P; Vaheri A; Carpén O (Aug 1998). "Association of ezrin with intercellular adhesion molecule-1 and -2 (ICAM-1 and ICAM-2). Regulation by phosphatidylinositol 4, 5-bisphosphate". J. Biol. Chem. (UNITED STATES) 273 (34): 21893–900. doi:10.1074/jbc.273.34.21893. ISSN 0021-9258. PMID 9705328. 
  4. ^ a b Serrador, Juan M; Vicente-Manzanares Miguel, Calvo Javier, Barreiro Olga, Montoya Maria C, Schwartz-Albiez Reinhard, Furthmayr Heinz, Lozano Francisco, Sánchez-Madrid Francisco (Mar 2002). "A novel serine-rich motif in the intercellular adhesion molecule 3 is critical for its ezrin/radixin/moesin-directed subcellular targeting". J. Biol. Chem. (United States) 277 (12): 10400–9. doi:10.1074/jbc.M110694200. ISSN 0021-9258. PMID 11784723. 
  5. ^ Serrador, J M; Alonso-Lebrero J L, del Pozo M A, Furthmayr H, Schwartz-Albiez R, Calvo J, Lozano F, Sánchez-Madrid F (Sep 1997). "Moesin interacts with the cytoplasmic region of intercellular adhesion molecule-3 and is redistributed to the uropod of T lymphocytes during cell polarization". J. Cell Biol. (UNITED STATES) 138 (6): 1409–23. doi:10.1083/jcb.138.6.1409. ISSN 0021-9525. PMC 2132557. PMID 9298994. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.