ICD-10 Chapter III: Diseases of the blood and blood-forming organs, and certain disorders involving the immune mechanism

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(Redirected from ICD-10 Chapters C and D: Neoplasms, diseases of the blood and blood-forming organs, and certain disorders involving the immune mechanism)

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Contents

1 C00-D48 - Neoplasms
2 D50-D89 - Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
3 See also

[edit] C00-D48 - Neoplasms

see now ICD-10 Chapter II: Neoplasms

[edit] D50-D89 - Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

[edit] (D50-D53) Nutritional anemias

(D50.) Iron deficiency anaemia
- (D 50.0) Iron deficiency anaemia secondary to blood loss (chronic)
- (D50.1) Sideropenic dysphagia
  - Kelly-Paterson syndrome
  - Plummer-Vinson syndrome
- (D 50.8) Other iron deficiency anaemias
- (D 50.9) Iron deficiency anaemia, unspecified

(D51.) Vitamin B12 deficiency anaemia
- (D51.0) Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
  - Pernicious anemia
- (D51.1) Vitamin B 12 deficiency anaemia due to selective vitamin B 12 malabsorption with proteinuria
  - Megaloblastic hereditary anaemia
- (D 51.2) Transcobalamin II deficiency
- (D 51.3) Other dietary vitamin B 12 deficiency anaemia
- (D 51.8) Other vitamin B 12 deficiency anaemias
- (D 51.9) Vitamin B 12 deficiency anaemia, unspecified

(D52.) Folate deficiency anaemia
- (D52.0) Dietary folate deficiency anaemia
  - Nutritional megaloblastic anaemia
- (D 52.1) Drug-induced folate deficiency anaemia
- (D 52.8) Other folate deficiency anaemias
- (D 52.9) Folate deficiency anaemia, unspecified

(D53.) Other nutritional anaemias
- (D 53.0) Protein deficiency anaemia
- (D 53.1) Other megaloblastic anaemias, not elsewhere classified
- (D 53.2) Scorbutic anaemia
- (D 53.8) Other specified nutritional anaemias
- (D 53.9) Nutritional anaemia, unspecified

[edit] (D55-D59) Haemolytic anaemias

(D55.) Anaemia due to enzyme disorders
- (D55.0) Anaemia due to glucose-6-phosphate dehydrogenase (G6PD) deficiency
  - Favism
  - G6PD deficiency anaemia
- (D 55.1) Anaemia due to other disorders of glutathione metabolism
- (D55.2) Anaemia due to disorders of glycolytic enzymes
- (D 55.3) Anaemia due to disorders of nucleotide metabolism
- (D 55.8) Other anaemias due to enzyme disorders
- (D 55.9) Anaemia due to enzyme disorder, unspecified

(D56.) Thalassaemia
- (D 56.0) Alpha thalassaemia
- (D 56.1) Beta thalassaemia
- (D 56.2) Delta-beta thalassaemia
- (D 56.3) Thalassaemia trait
- (D 56.4) Hereditary persistence of fetal haemoglobin (HPFH)
- (D 56.8) Other thalassaemias
- (D 56.9) Thalassaemia, unspecified

(D57.) Sickle-cell disorders
- (D 57.0) Sickle-cell anaemia with crisis
- (D 57.1) Sickle-cell anaemia without crisis
- (D 57.2) Double heterozygous sickling disorders
- (D 57.3) Sickle-cell trait
- (D 57.8) Other sickle-cell disorders

(D58.) Other hereditary haemolytic anaemias
- (D58.0) Hereditary spherocytosis
- (D58.1) Hereditary elliptocytosis
  - Elliptocytosis (congenital)
  - Ovalocytosis (congenital)(hereditary)
- (D58.2) Other haemoglobinopathies
- (D58.8) Other specified hereditary haemolytic anaemias
  - Stomatocytosis

(D59.) Acquired haemolytic anaemia
- (D 59.0) Drug-induced autoimmune haemolytic anaemia
- (D59.1) Other autoimmune haemolytic anaemias
  - Warm autoimmune hemolytic anemia
- (D 59.2) Drug-induce nonautoimmune haemolytic anaemia
- (D 59.3) Haemolytic-uraemic syndrome
- (D59.4) Other nonautoimmune haemolytic anaemias
  - Microangiopathic hemolytic anemia
- (D 59.5) Paroxysmal nocturnal haemoglobinuria (Marchiafava-Micheli)
- (D59.6) Haemoglobinuria due to haemolysis from other external causes
  - paroxysmal cold haemoglobinuria
- (D 59.8) Other acquired haemolytic anaemias
- (D 59.9) Acquired haemolytic anaemia, unspecified

[edit] (D60-D64) Aplastic and other anaemias

(D 60.) Acquired pure red cell aplasia (erythroblastopenia)

(D61.) Other aplastic anaemias
- (D61.0) Constitutional aplastic anaemia
- (D 61.1) Drug-induced aplastic anaemia
- (D 61.2) Aplastic anaemia due to other external agents
- (D 61.3) Idiopathic aplastic anaemia
- (D 61.8) Other specified aplastic anaemias
- (D61.9) Aplastic anaemia, unspecified

(D 62.) Acute posthaemorrhagic anaemia
(D 63.) Anaemia in chronic diseases classified elsewhere

(D64.) Other anaemias
- (D 64.0) Hereditary sideroblastic anaemia
- (D 64.1) Secondary sideroblastic anaemia due to disease
- (D 64.2) Secondary sideroblastic anaemia due to drugs and toxins
- (D 64.3) Other sideroblastic anaemias
- (D 64.4) Congenital dyserythropoietic anaemia
- (D 64.8) Other specified anaemias
- (D 64.9) Anaemia, unspecified

[edit] (D65-D69) Coagulation defects, purpura and other haemorrhagic conditions

(D65.) Disseminated intravascular coagulation (defibrination syndrome)
- Afibrinogenaemia, acquired
- Consumption coagulopathy
- Diffuse or disseminated intravascular coagulation (DIC)
- Fibrinolytic haemorrhage, acquired
- Fibrinolytic purpura
- Purpura fulminans

(D66.) Hereditary factor VIII deficiency
- Haemophilia A

(D67.) Hereditary factor IX deficiency
- Christmas disease
- Haemophilia B

(D68.) Other coagulation defects
- (D 68.0) Von Willebrand's disease
- (D68.1) Hereditary factor XI deficiency
  - Haemophilia C
- (D 68.2) Hereditary deficiency of other clotting factors
- (D 68.3) Haemorrhagic disorder due to circulating anticoagulants
- (D 68.4) Acquired coagulation factor deficiency
- (D 68.8) Other specified coagulation defects
- (D 68.9) Coagulation defect, unspecified

(D69.) Purpura and other haemorrhagic conditions
- (D69.0) Allergic purpura
  - anaphylactoid purpura
  - Henoch-Schönlein purpura
- (D69.1) Qualitative platelet defects
  - Bernard-Soulier syndrome (giant platelet)
  - Glanzmann's disease
  - Grey platelet syndrome
  - Thromboasthenia (haemorrhagic)(hereditary)
  - Thrombocytopathy
- (D 69.2) Other nonthrombocytopenic purpura
- (D69.3) Idiopathic thrombocytopenic purpura
  - Evans' syndrome
- (D 69.4) Other primary thrombocytopenia
- (D 69.5) Secondary thrombocytopenia
- (D 69.6) Thrombocytopenia, unspecified
- (D 69.8) Other specified haemorrhagic conditions
- (D 69.9) Haemorrhagic condition, unspecified

[edit] (D70-D77) Other diseases of blood and blood-forming organs

(D70.) Agranulocytosis

(D71.) Functional disorders of polymorphonuclear neutrophils

(D72.) Other disorders of white blood cells
- (D72.0) Genetic anomalies of leukocytes
- (D 72.1) Eosinophilia
- (D72.8) Other specified disorders of white blood cells
  - Leukaemoid reaction: lymphocytic, monocytic, myelocytic
  - Leukocytosis
  - Lymphocytosis (symptomatic)
  - Lymphopenia
  - Monocytosis (symptomatic)
  - Plasmacytosis
- (D 72.9) Disorder of white blood cells, unspecified

(D73.) Diseases of spleen
- (D 73.0) Hyposplenism
- (D 73.1) Hypersplenism
- (D 73.2) Chronic congestive splenomegaly
- (D 73.3) Abscess of spleen
- (D 73.4) Cyst of spleen
- (D 73.5) Infarction of spleen
- (D 73.8) Other diseases of spleen
- (D 73.9) Disease of spleen, unspecified

(D74.) Methaemoglobinaemia
- (D74.0) Congenital methaemoglobinaemia
  - Congenital NADH-methaemoglobin reductase deficiency
  - Haemoglobin-M (Hb-M) disease
  - Methaemoglobinaemia, hereditary
- (D74.8) Other methaemoglobinaemias
  - Acquired methaemoglobinaemia (with sulfhaemoglobinaemia)
  - Toxic methaemoglobinaemia
- (D 74.9) Methaemoglobinaemia, unspecified

(D75.) Other diseases of blood and blood-forming organs
- (D 75.0) Familial erythrocytosis
- (D 75.1) Secondary polycythaemia
- (D 75.2) Essential thrombocytosis
- (D75.8) Other specified diseases of blood and blood-forming organs
  - Basophilia
- (D 75.9) Disease of blood and blood-forming organs, unspecified

(D76.) Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
- (D76.0) Langerhans' cell histiocytosis, not elsewhere classified
  - Eosinophilic granuloma
  - Hand-Schüller-Christian disease
  - Histiocytosis X (chronic)
- (D76.1) Haemophagocytic lymphohistiocytosis
  - Familial haemophagocytic reticulosis
- (D 76.2) Haemophagocytic syndrome, infection-associated
- (D76.3) Other histiocytosis syndromes
  - Reticulohistiocytoma (giant-cell)
  - Sinus histiocytosis with massive lymphadenopathy
  - Xanthogranuloma

(D 77.) Other disorders of blood and blood-forming organs in diseases classified elsewhere

[edit] (D80-D89) Certain disorders involving the immune mechanism

(D80.) Immunodeficiency with predominantly antibody defects
- (D80.0) Hereditary hypogammaglobulinaemia
  - Autosomal recessive agammaglobulinaemia (Swiss type)
  - X-linked agammaglobulinaemia (Bruton) (with growth hormone deficiency)
- (D80.1) Nonfamilial hypogammaglobulinaemia
- (D 80.2) Selective deficiency of immunoglobulin A (IgA)
- (D 80.3) Selective deficiency of immunoglobulin G (IgG) subclasses
- (D 80.4) Selective deficiency of immunoglobulin M (IgM)
- (D 80.5) Immunodeficiency with increased immunoglobulin M (IgM)
- (D 80.6) Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia
- (D 80.7) Transient hypogammaglobulinaemia of infancy
- (D80.8) Other immunodeficiencies with predominantly antibody defects
  - Kappa light chain deficiency
- (D 80.8) Immunodeficiency with predominantly antibody defects, unspecified

(D81.) Combined immunodeficiencies
- (D 81.0) Severe combined immunodeficiency (SCID) with reticular dysgenesis
- (D 81.1) Severe combined immunodeficiency (SCID) with low T-cell and B-cell numbers
- (D 81.2) Severe combined immunodeficiency (SCID) with low or normal B-cell numbers
- (D 81.3) Adenosine deaminase deficiency (ADA)
- (D 81.4) Nezelof's syndrome
- (D 81.5) Purine nucleoside phosphorylase deficiency (PNP)
- (D81.6) Major histocompatibility complex class I deficiency
  - Bare lymphocyte syndrome
- (D 81.7) Major histocompatibility complex class II deficiency
- (D81.8) Other combined immunodeficiencies
  - Biotin-dependent carboxylase deficiency
- (D81.9) Combined immunodeficiency, unspecified
  - Severe combined immunodeficiency disorder (SCID) NOS

(D82.) Immunodeficiency associated with other major defects
- (D82.0) Wiskott-Aldrich syndrome
  - Immunodeficiency with thrombocytopenia and eczema
- (D 82.1) Di George's syndrome
- (D 82.2) Immunodeficiency with short-limbed stature
- (D82.3) Immunodeficiency following hereditary defective response to Epstein-Barr virus
  - X-linked lymphoproliferative disease
- (D 82.4) Hyperimmunoglobulin E syndrome (IgE)
(D 83.) Common variable immunodeficiency

(D84.) Other immunodeficiencies
- (D 84.0) Lymphocyte function antigen-1 (LFA-1) defect
- (D84.1) Defects in the complement system
  - C1 esterase inhibitor deficiency (C1-INH)
- (D 84.8) Other specified immunodeficiencies
- (D 84.9) Immunodeficiency, unspecified

(D86.) Sarcoidosis
- (D 86.0) Sarcoidosis of lung
- (D 86.1) Sarcoidosis of lymph nodes
- (D 86.2) Sarcoidosis of lung with sarcoidosis of lymph nodes
- (D 86.3) Sarcoidosis of skin
- (D 86.8) Sarcoidosis of other and combined sites
(D89.) Other disorders involving the immune mechanism, not elsewhere classified
- (D89.0) Polyclonal hypergammaglobulinaemia
  - Benign hypergammaglobulinaemic purpura
  - Polyclonal gammopathy NOS
- (D 89.1) Cryoglobulinaemia
- (D 89.2) Hypergammaglobulinaemia, unspecified
- (D 89.8) Other specified disorders involving the immune mechanism, not elsewhere classified
- (D 89.9) Disorder involving the immune mechanism, unspecified

[edit] See also

Pathology: Medical conditions (Diseases/Disorders/Illness, Syndromes/Sequences, Symptoms/Signs, Injuries, etc.) and ICD codes

Infectious disease/Infection: Bacterial disease (G+, G-) · Virus disease · Parasitic disease (Protozoan infection, Helminthiasis, Ectoparasitic infestation) · Mycosis · Zoonosis

(C/D,
140-239 & 280-289)

Cancer (C00-D48, 140-239)	Tumor

Myeloid hematologic (D50-D77, 280-289)	Anemia · Coagulopathy

Lymphoid immune (D80-D89, 279)	Immunodeficiency · Immunoproliferative disorder · Hypersensitivity

Endocrine disease · Nutrition disorder · Inborn error of metabolism

Mental disorder

Nervous system disease (CNS, PNS) · Neuromuscular disease

Eye disease · Ear disease

Cardiovascular disease (Heart disease, Vascular disease)

Respiratory disease (Obstructive lung disease, Restrictive lung disease, Pneumonia)

Stomatognathic disease (Tooth disease) · Digestive disease (Esophageal, Stomach, Enteropathy, Liver, Pancreatic)

Skin disease · skin appendages (Nail disease, Hair disease, Sweat gland disease)

Musculoskeletal disorders · Osteochondropathy (Osteopathy, Chondropathy)

Urologic disease (Nephropathy, Urinary bladder disease) · Male genital disease · Breast disease · Female genital disease

Complications of pregnancy · Obstetric labor complication · Puerperal disorder

Congenital disorder

Syndromes · Medical signs (Eponymous)

Bone fracture · Joint dislocation · Sprain · Strain · subluxation · Head injury · Chest trauma · Poisoning

Pathology: hematology · hematologic diseases of RBCs and megakaryocytes / MEP (D50-69,74, 280-287)

Red
blood cells

↑

Polycythemia vera

↓

Micro-: Iron deficiency anemia (Plummer-Vinson syndrome)

Macro-: Megaloblastic anemia (Pernicious anemia)

Hemolytic
(mostly Normo-)

Hereditary	enzymopathy: G6PD · glycolysis (PK, TI, HK) hemoglobinopathy: Thalassemia (alpha, beta, delta) · Sickle-cell disease/trait · HPFH membrane: Hereditary spherocytosis (Minkowski-Chauffard syndrome) · Hereditary elliptocytosis (Ovalocytosis) · Hereditary stomatocytosis

Acquired	Autoimmune (WAHA, CAD, PCH) membrane (PNH) MAHA · TM (HUS) Drug-induced autoimmune · Drug-induced nonautoimmune Hemolytic disease of the newborn

Aplastic
(mostly Normo-)

Hereditary: Fanconi anemia · Diamond-Blackfan anemia

Acquired: PRCA · Sideroblastic anemia · Myelophthisic

MCV (Normocytic, Microcytic, Macrocytic) · MCHC (Normochromic, Hypochromic)

Other

Methemoglobinemia · Sulfhemoglobinemia · Reticulocytopenia

Coagulation/
coagulopathy/
bleeding
diathesis

↑

Thrombocytosis	Essential thrombocytosis

Hypercoagulability	primary: Antithrombin III deficiency · Protein C deficiency/Activated protein C resistance/Protein S deficiency/Factor V Leiden · Hyperprothrombinemia acquired: DIC (Congenital afibrinogenemia, Purpura fulminans) · autoimmune (Antiphospholipid)

↓

myeloid navs: cells/physio, disease of RBCs+megakaryocytes/monocytes+granulocytes/neoplasia, symptoms+signs/eponymous
↑ means increased, ↓ means decreased

v • d • e Lymphatic disease: splenic disease (D73/Q89.0, 289.4-289.5/759.0)

Acquired	Acquired asplenia/hyposplenism · Wandering spleen · Splenomegaly (Banti's syndrome)

Congenital	Congenital asplenia/hyposplenism · Accessory spleen · Polysplenia

lymphatic organ navs: anat, physio, lymphatic disease/splenic disease/thymus disorders/thymus neoplasia/vascular tumors, proc

v • d • e Lymphatic disease: histiocytosis (D76.0, 277.89)

WHO-I/Langerhans cell histiocytosis	Letterer-Siwe disease · Hand-Schüller-Christian disease · Eosinophilic granuloma

WHO-II/non-Langerhans cell histiocytosis	Juvenile xanthogranuloma · Hemophagocytic lymphohistiocytosis · Erdheim-Chester disease · Niemann-Pick disease · Sea-blue histiocyte syndrome

WHO-III/malignant histiocytosis	Histiocytic sarcoma · Langerhans cell sarcoma · Interdigitating dendritic cell sarcoma · Follicular dendritic cell sarcoma

Immune disorders: Lymphoid and complement immunodeficiency (D80-D85, 279)

Antibody/humoral (B)

Hypogammaglobulinemia	X-linked agammaglobulinemia · Transient hypogammaglobulinemia of infancy

Dysgammaglobulinemia	IgA deficiency · IgG deficiency · IgM deficiency · Hyper IgM syndrome (2, 3, 4, 5) · Wiskott-Aldrich syndrome · Hyper-IgE syndrome

Other	Common variable immunodeficiency · ICF syndrome

Cell-mediated (T)

thymic hypoplasia: hypoparathyroid (Di George's syndrome) · euparathyroid (Nezelof syndrome, Ataxia telangiectasia)

peripheral: Purine nucleoside phosphorylase deficiency · Hyper IgM syndrome (1)

Severe combined (B+T)

x-linked: X-SCID
autosomal: Adenosine deaminase deficiency · Omenn syndrome · ZAP70 deficiency · Bare lymphocyte syndrome

Lymphocytopenia

Idiopathic CD4+ lymphocytopenia

Complement deficiency

C1-inhibitor (Angioedema/Hereditary angioedema) · Complement 2 deficiency

lymphocyte navs: cells/physio, immunodeficiency/immunoproliferative immunoglobulin/neoplasia, proc

v • d • e Sarcoidosis (D86, 135)

Integuement	Annular sarcoidosis · Erythrodermic sarcoidosis · Ichthyosiform sarcoidosis · Hypopigmented sarcoidosis · Lupus pernio · Morpheaform sarcoidosis · Mucosal sarcoidosis · Papular sarcoid · Scar sarcoid · Subcutaneous sarcoidosis · Ulcerative sarcoidosis

Central nervous system	Neurosarcoidosis

Lymph node	Löfgren syndrome

Systemic	Systemic sarcoidosis

v • d • e Immune disorders, Immunoproliferative immunoglobulin disorders (D89, 273)

PCDs/PP	Plasmacytoma · Multiple myeloma (Plasma cell leukemia) · MGUS · IgM (Macroglobulinemia/Waldenström's macroglobulinemia) · heavy chain (Heavy chain disease) · light chain (Primary amyloidosis)

Other hypergammaglobulinemia	Cryoglobulinemia

lymphocyte navs: cells/physio, immunodeficiency/immunoproliferative immunoglobulin/neoplasia, proc

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