ICI-204,448

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ICI-204,448
ICI-204448 structure.png
Systematic (IUPAC) name
2-(3-[1-([2-(3,4-dichlorophenyl)acetyl]-methylamino)-2-pyrrolidin-1-ylethyl]phenoxy)acetic acid
Clinical data
Legal status
?
Identifiers
CAS number 121264-04-8 YesY
ATC code ?
PubChem CID 3683
ChEMBL CHEMBL23472 N
Chemical data
Formula C23H26Cl2N2O4 
Mol. mass 465.368 g/mol
 N (what is this?)  (verify)

ICI-204,448 is a drug which acts as a potent and peripherally selective κ-opioid agonist, with possible uses in the treatment of heart attack as well as anti-itching effects.[1][2] It is used in research to distinguish centrally from peripherally mediated kappa opioid receptor effects.[3][4]

References[edit]

  1. ^ Peart JN, Gross ER, Gross GJ (March 2004). "Effect of exogenous kappa-opioid receptor activation in rat model of myocardial infarction". Journal of Cardiovascular Pharmacology 43 (3): 410–5. doi:10.1097/00005344-200403000-00012. PMID 15076225. 
  2. ^ Inan S, Cowan A (October 2004). "Kappa opioid agonists suppress chloroquine-induced scratching in mice". European Journal of Pharmacology 502 (3): 233–7. doi:10.1016/j.ejphar.2004.09.010. PMID 15476749. 
  3. ^ Schindler CW, Graczyk Z, Gilman JP, Negus SS, Bergman J, Mello NK, Goldberg SR (December 2007). "Effects of kappa opioid agonists alone and in combination with cocaine on heart rate and blood pressure in conscious squirrel monkeys". European Journal of Pharmacology 576 (1-3): 107–13. doi:10.1016/j.ejphar.2007.07.053. PMC 2080578. PMID 17707792. 
  4. ^ Shannon HE, Eberle EL, Mitch CH, McKinzie DL, Statnick MA (December 2007). "Effects of kappa opioid receptor agonists on attention as assessed by a 5-choice serial reaction time task in rats". Neuropharmacology 53 (8): 930–41. doi:10.1016/j.neuropharm.2007.09.002. PMID 17959202.