ICMT

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Isoprenylcysteine carboxyl methyltransferase
Identifiers
Symbols ICMT ; HSTE14; MST098; MSTP098; PCCMT; PCMT; PPMT
External IDs OMIM605851 MGI1888594 HomoloGene5735 ChEMBL: 4699 GeneCards: ICMT Gene
EC number 2.1.1.100
RNA expression pattern
PBB GE ICMT 201611 s at tn.png
PBB GE ICMT 201609 x at tn.png
PBB GE ICMT 201610 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 23463 57295
Ensembl ENSG00000116237 ENSMUSG00000039662
UniProt O60725 Q9EQK7
RefSeq (mRNA) NM_012405 NM_133788
RefSeq (protein) NP_036537 NP_598549
Location (UCSC) Chr 1:
6.28 – 6.3 Mb
Chr 4:
152.3 – 152.31 Mb
PubMed search [1] [2]

Protein-S-isoprenylcysteine O-methyltransferase is an enzyme that in humans is encoded by the ICMT gene.[1][2][3]

This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined.[3]

References[edit]

  1. ^ Dai Q, Choy E, Chiu V, Romano J, Slivka SR, Steitz SA, Michaelis S, Philips MR (Jul 1998). "Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum". J Biol Chem 273 (24): 15030–4. doi:10.1074/jbc.273.24.15030. PMID 9614111. 
  2. ^ Desrosiers RR, Nguyen QT, Beliveau R (Sep 1999). "The carboxyl methyltransferase modifying G proteins is a metalloenzyme". Biochem Biophys Res Commun 261 (3): 790–7. doi:10.1006/bbrc.1999.0936. PMID 10441503. 
  3. ^ a b "Entrez Gene: ICMT isoprenylcysteine carboxyl methyltransferase". 

Further reading[edit]