IDH3A

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Isocitrate dehydrogenase 3 (NAD+) alpha
Identifiers
Symbol IDH3A
External IDs OMIM601149 MGI1915084 HomoloGene4037 GeneCards: IDH3A Gene
EC number 1.1.1.41
RNA expression pattern
PBB GE IDH3A 202069 s at tn.png
PBB GE IDH3A 202070 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3419 67834
Ensembl ENSG00000166411 ENSMUSG00000032279
UniProt P50213 Q9D6R2
RefSeq (mRNA) NM_005530 NM_029573
RefSeq (protein) NP_005521 NP_083849
Location (UCSC) Chr 15:
78.42 – 78.46 Mb
Chr 9:
54.59 – 54.6 Mb
PubMed search [1] [2]

Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial is an enzyme that in humans is encoded by the IDH3A gene.[1][2]

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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TCA Cycle edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "TCACycle_WP78". 

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the alpha subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase.[2]

References[edit]

  1. ^ Huh TL, Kim YO, Oh IU, Song BJ, Inazawa J (May 1997). "Assignment of the human mitochondrial NAD+ -specific isocitrate dehydrogenase alpha subunit (IDH3A) gene to 15q25.1→q25.2by in situ hybridization". Genomics 32 (2): 295–6. doi:10.1006/geno.1996.0120. PMID 8833160. 
  2. ^ a b "Entrez Gene: IDH3A isocitrate dehydrogenase 3 (NAD+) alpha". 

Further reading[edit]