IDH3G

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Isocitrate dehydrogenase 3 (NAD+) gamma
Identifiers
Symbols IDH3G ; H-IDHG
External IDs OMIM300089 MGI1099463 HomoloGene55803 GeneCards: IDH3G Gene
EC number 1.1.1.41
RNA expression pattern
PBB GE IDH3G 202471 s at tn.png
PBB GE IDH3G 214333 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3421 15929
Ensembl ENSG00000067829 ENSMUSG00000002010
UniProt P51553 P70404
RefSeq (mRNA) NM_004135 NM_008323
RefSeq (protein) NP_004126 NP_032349
Location (UCSC) Chr HG1497_PATCH:
152.95 – 152.96 Mb
Chr X:
73.78 – 73.79 Mb
PubMed search [1] [2]

Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial is an enzyme that in humans is encoded by the IDH3G gene.[1][2]

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the gamma subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. This gene is a candidate gene for periventricular heterotopia. Several alternatively spliced transcript variants of this gene have been described, but only some of their full length natures have been determined.[2]

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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TCACycle_WP78 go to article go to article go to article go to article go to HMDB go to article go to article go to article Go to article go to article go to article go to article go to article go to article Go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to HMDB go to article go to article go to HMDB go to article go to article go to HMDB go to article go to article go to HMDB go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to WikiPathways go to article go to article go to article go to article
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  1. ^ The interactive pathway map can be edited at WikiPathways: "TCACycle_WP78". 

References[edit]

  1. ^ Brenner V, Nyakatura G, Rosenthal A, Platzer M (Nov 1997). "Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse". Genomics 44 (1): 8–14. doi:10.1006/geno.1997.4822. PMID 9286695. 
  2. ^ a b "Entrez Gene: IDH3G isocitrate dehydrogenase 3 (NAD+) gamma". 

Further reading[edit]