IFI27

Interferon, alpha-inducible protein 27
Identifiers
Symbols	IFI27; FAM14D; ISG12; ISG12A; P27
External IDs	OMIM: 600009 MGI: 1277180 HomoloGene: 84735 GeneCards: IFI27 Gene
Gene Ontology Molecular function • molecular_function Cellular component • mitochondrion • membrane • integral to membrane Biological process • activation of caspase activity • induction of apoptosis by extracellular signals • activation of pro-apoptotic gene products • cytokine-mediated signaling pathway • type I interferon-mediated signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3429	52668
Ensembl	ENSG00000165949	ENSMUSG00000064215
UniProt	P40305	n/a
RefSeq (mRNA)	NM_001130080.1	NM_026790
RefSeq (protein)	NP_001123552.1	NP_081066
Location (UCSC)	Chr 14: 94.58 – 94.58 Mb	Chr 12: 104.67 – 104.68 Mb
PubMed search	[1]	[2]

Interferon alpha-inducible protein 27 is a protein that in humans is encoded by the IFI27 gene.

Further reading

• Taulés M, Rius E, Talaya D, et al. (1999). "Calmodulin is essential for cyclin-dependent kinase 4 (Cdk4) activity and nuclear accumulation of cyclin D1-Cdk4 during G1.". J. Biol. Chem. 273 (50): 33279–86. doi:10.1074/jbc.273.50.33279. PMID 9837900. 
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310948. 
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=311072. 
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1083732. 
• Martensen PM, Søgaard TM, Gjermandsen IM, et al. (2001). "The interferon alpha induced protein ISG12 is localized to the nuclear membrane.". Eur. J. Biochem. 268 (22): 5947–54. doi:10.1046/j.0014-2956.2001.02545.x. PMID 11722583. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages.". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042. 
• Smidt KC, Hansen LL, Søgaard TM, et al. (2003). "A nine-nucleotide deletion and splice variation in the coding region of the interferon induced ISG12 gene.". Biochim. Biophys. Acta 1638 (3): 227–34. PMID 12878323. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Taguchi T, Kato Y, Baba Y, et al. (2004). "Protein levels of p21, p27, cyclin E and Bax predict sensitivity to cisplatin and paclitaxel in head and neck squamous cell carcinomas.". Oncol. Rep. 11 (2): 421–6. PMID 14719078. 
• Parker N, Porter AC (2004). "Identification of a novel gene family that includes the interferon-inducible human genes 6-16 and ISG12.". BMC Genomics 5: 8. doi:10.1186/1471-2164-5-8. PMC 343271. PMID 14728724. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=343271. 
• Namciu SJ, Friedman RD, Marsden MD, et al. (2004). "Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1.". Mamm. Genome 15 (3): 162–78. doi:10.1007/s00335-003-2311-y. PMID 15014966. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528930. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1347501. 
• Fjaerli HO, Bukholm G, Krog A, et al. (2007). "Whole blood gene expression in infants with respiratory syncytial virus bronchiolitis.". BMC Infect. Dis. 6: 175. doi:10.1186/1471-2334-6-175. PMC 1713240. PMID 17166282. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1713240.