IFITM3

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Interferon induced transmembrane protein 3
Identifiers
Symbols IFITM3 ; 1-8U; DSPA2b; IP15
External IDs OMIM605579 MGI1913391 HomoloGene136199 GeneCards: IFITM3 Gene
Orthologs
Species Human Mouse
Entrez 10410 66141
Ensembl ENSG00000142089 ENSMUSG00000025492
UniProt Q01628 Q9CQW9
RefSeq (mRNA) NM_021034 NM_025378
RefSeq (protein) NP_066362 NP_079654
Location (UCSC) Chr 11:
0.32 – 0.33 Mb
Chr 7:
141.01 – 141.01 Mb
PubMed search [1] [2]

Interferon-induced transmembrane protein 3 (IFITM3) is a protein that in humans is encoded by the IFITM3 gene.[1][2][3] It is reported to play a critical role in the immune system's defense against Swine Flu, where heightened levels of IFITM3 keep viral levels low, and the removal of IFITM3 allows the virus to multiply unchecked [3]. This observation has been further advanced by a recent study that shows that a single nucleotide polymorphism in the human IFITM3 gene purported to increase influenza susceptibility is overrepresented in people hospitalised with pandemic H1N1.[4] The prevalence of this mutation is thought to be approximately 1/400 in European populations[4][4].


Model organisms[edit]

Model organisms have been used in the study of IFITM3 function. A conditional knockout mouse line, called Ifitm3tm1Masu[9][10] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[11][12][13]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[7][14] Twenty four tests were carried out on mutant mice, but no significant abnormalities were observed.[7] However, challenge with influenza A virus indicated that these mice display increased viral susceptibility.[4]

References[edit]

  1. ^ Lewin AR, Reid LE, McMahon M, Stark GR, Kerr IM (Aug 1991). "Molecular analysis of a human interferon-inducible gene family". Eur J Biochem 199 (2): 417–423. doi:10.1111/j.1432-1033.1991.tb16139.x. PMID 1906403. 
  2. ^ Tanaka SS, Yamaguchi YL, Tsoi B, Lickert H, Tam PP (Dec 2005). "IFITM/Mil/fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion". Dev Cell 9 (6): 745–756. doi:10.1016/j.devcel.2005.10.010. PMID 16326387. 
  3. ^ "Entrez Gene: IFITM3 interferon induced transmembrane protein 3 (1-8U)". 
  4. ^ a b c Everitt A.R. et al. (March 2012). "IFITM3 restricts the morbidity and mortality associated with influenza.". Nature. advance online publication (7395): 519–23. doi:10.1038/nature10921. PMID 22446628. 
  5. ^ "Salmonella infection data for Ifitm3". Wellcome Trust Sanger Institute. 
  6. ^ "Citrobacter infection data for Ifitm3". Wellcome Trust Sanger Institute. 
  7. ^ a b c Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x. 
  8. ^ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  9. ^ "International Knockout Mouse Consortium". 
  10. ^ "Mouse Genome Informatics". 
  11. ^ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.  edit
  12. ^ Dolgin E (June 2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718. 
  13. ^ Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. 
  14. ^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353. 

Further reading[edit]