IFNA2

Interferon, alpha 2
PDB rendering based on 1itf.
Available structures PDB 1ITF, 1RH2, 2HIE, 2HYM, 2KZ1
Identifiers
Symbols	IFNA2; IFN-alphaA; IFNA; INFA2; MGC125764; MGC125765
External IDs	OMIM: 147562 HomoloGene: 86655 GeneCards: IFNA2 Gene
Gene Ontology Molecular function • cytokine activity • interferon-alpha/beta receptor binding • protein binding Cellular component • extracellular region • extracellular region • extracellular space Biological process • induction of apoptosis • inflammatory response • cell surface receptor linked signaling pathway • cell-cell signaling • blood coagulation • response to virus • negative regulation of gene expression • cytokine-mediated signaling pathway • negative regulation of T cell differentiation • negative regulation of transcription, DNA-dependent • type I interferon-mediated signaling pathway • regulation of type I interferon-mediated signaling pathway • negative regulation of T-helper 2 cell cytokine production • negative regulation of interleukin-5 secretion • negative regulation of interleukin-13 secretion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3440	n/a
Ensembl	ENSG00000188379	n/a
UniProt	P01563	n/a
RefSeq (mRNA)	NM_000605	n/a
RefSeq (protein)	NP_000596	n/a
Location (UCSC)	Chr 9: 21.38 – 21.39 Mb	n/a
PubMed search	[1]	n/a

Interferon alpha-2 is a protein that in humans is encoded by the IFNA2 gene.

Interactions

IFNA2 has been shown to interact with IFNAR2.

Further reading

• Conti L, Fantuzzi L, Del Cornò M et al. (2005). "Immunomodulatory effects of the HIV-1 gp120 protein on antigen presenting cells: implications for AIDS pathogenesis". Immunobiology 209 (1–2): 99–115. doi:10.1016/j.imbio.2004.02.008. PMID 15481145. 
• Capobianchi MR, Ankel H, Ameglio F et al. (1992). "Recombinant glycoprotein 120 of human immunodeficiency virus is a potent interferon inducer". AIDS Res. Hum. Retroviruses 8 (5): 575–9. doi:10.1089/aid.1992.8.575. PMID 1381203. 
• Flores I, Mariano TM, Pestka S (1991). "Human interferon omega (omega) binds to the alpha/beta receptor". J. Biol. Chem. 266 (30): 19875–7. PMID 1834641. 
• Tyring SK, Cauda R, Tumbarello M et al. (1991). "Synthetic peptides corresponding to sequences in HIV envelope gp41 and gp120 enhance in vitro production of interleukin-1 and tumor necrosis factor but depress production of interferon-alpha, interferon-gamma and interleukin-2". Viral Immunol. 4 (1): 33–42. doi:10.1089/vim.1991.4.33. PMID 1905933. 
• Adolf GR, Kalsner I, Ahorn H et al. (1991). "Natural human interferon-alpha 2 is O-glycosylated". Biochem. J. 276 ( Pt 2) (Pt 2): 511–8. PMC 1151121. PMID 2049076. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1151121. 
• Stine KC, Bolognesi D, Weinhold KJ (1989). "Cytokine augmentation of human immunodeficiency virus type 1 (HIV-1) gp120-specific cellular cytotoxicity". Journal of biological response modifiers 8 (5): 501–10. PMID 2552026. 
• Oliver G, Balbás P, Valle F et al. (1986). "[Cloning of human leukocyte interferon cDNA and a strategy for its production in E. coli]". Rev. Latinoam. Microbiol. 27 (2): 141–50. PMID 3906813. 
• Streuli M, Nagata S, Weissmann C (1980). "At least three human type alpha interferons: structure of alpha 2". Science 209 (4463): 1343–7. doi:10.1126/science.6158094. PMID 6158094. 
• Allen G, Fantes KH (1981). "A family of structural genes for human lymphoblastoid (leukocyte-type) interferon". Nature 287 (5781): 408–11. doi:10.1038/287408a0. PMID 6159537. 
• Goeddel DV, Yelverton E, Ullrich A et al. (1981). "Human leukocyte interferon produced by E. coli is biologically active". Nature 287 (5781): 411–6. doi:10.1038/287411a0. PMID 6159538. 
• Wetzel R (1981). "Assignment of the disulphide bonds of leukocyte interferon". Nature 289 (5798): 606–7. doi:10.1038/289606a0. PMID 6162107. 
• Goeddel DV, Leung DW, Dull TJ et al. (1981). "The structure of eight distinct cloned human leukocyte interferon cDNAs". Nature 290 (5801): 20–6. doi:10.1038/290020a0. PMID 6163083. 
• Maeda S, McCandliss R, Gross M et al. (1981). "Construction and identification of bacterial plasmids containing nucleotide sequence for human leukocyte interferon". Proc. Natl. Acad. Sci. U.S.A. 77 (12): 7010–3. doi:10.1073/pnas.77.12.7010. PMC 350430. PMID 6164056. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=350430. 
• Lawn RM, Gross M, Houck CM et al. (1982). "DNA sequence of a major human leukocyte interferon gene". Proc. Natl. Acad. Sci. U.S.A. 78 (9): 5435–9. doi:10.1073/pnas.78.9.5435. PMC 348760. PMID 6170983. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=348760. 
• Weber H, Weissmann C (1983). "Formation of genes coding for hybrid proteins by recombination between related, cloned genes in E. coli". Nucleic Acids Res. 11 (16): 5661–9. doi:10.1093/nar/11.16.5661. PMC 326304. PMID 6310510. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=326304. 
• Ameglio F, Capobianchi MR, Castilletti C et al. (1994). "Recombinant gp120 induces IL-10 in resting peripheral blood mononuclear cells; correlation with the induction of other cytokines". Clin. Exp. Immunol. 95 (3): 455–8. doi:10.1111/j.1365-2249.1994.tb07018.x. PMC 1535081. PMID 7511078. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1535081. 
• Ankel H, Capobianchi MR, Castilletti C, Dianzani F (1994). "Interferon induction by HIV glycoprotein 120: role of the V3 loop". Virology 205 (1): 34–43. doi:10.1006/viro.1994.1617. PMID 7526537. 
• Nair MP, Chadha KC, Stadler I et al. (1995). "Differential effects of human immunodeficiency virus type 1 envelope protein gp120 on interferon production by mononuclear cells from adults and neonates". Clin. Diagn. Lab. Immunol. 2 (4): 434–8. PMC 170174. PMID 7583919. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=170174. 
• Lee N, Ni D, Brissette R et al. (1995). "Interferon-alpha 2 variants in the human genome". J. Interferon Cytokine Res. 15 (4): 341–9. doi:10.1089/jir.1995.15.341. PMID 7627809.