IFNAR1

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Interferon (alpha, beta and omega) receptor 1
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols IFNAR1 ; AVP; IFN-alpha-REC; IFNAR; IFNBR; IFRC
External IDs OMIM107450 MGI107658 HomoloGene524 ChEMBL: 1887 GeneCards: IFNAR1 Gene
RNA expression pattern
PBB GE IFNAR1 204191 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3454 15975
Ensembl ENSG00000142166 ENSMUSG00000022967
UniProt P17181 P33896
RefSeq (mRNA) NM_000629 NM_010508
RefSeq (protein) NP_000620 NP_034638
Location (UCSC) Chr 21:
34.7 – 34.73 Mb
Chr 16:
91.49 – 91.51 Mb
PubMed search [1] [2]

Interferon-alpha/beta receptor alpha chain is a protein that in humans is encoded by the IFNAR1 gene.[1][2]

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor.[2]

Interactions[edit]

IFNAR1 has been shown to interact with STAT2,[3][4][5] Tyrosine kinase 2[6][7] and PRMT1.[8]

References[edit]

  1. ^ Novick D, Cohen B, Rubinstein M (Jun 1994). "The human interferon alpha/beta receptor: characterization and molecular cloning". Cell 77 (3): 391–400. doi:10.1016/0092-8674(94)90154-6. PMID 8181059. 
  2. ^ a b "Entrez Gene: IFNAR1 interferon (alpha, beta and omega) receptor 1". 
  3. ^ Li, X; Leung S; Kerr I M; Stark G R (Apr 1997). "Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling". Mol. Cell. Biol. (UNITED STATES) 17 (4): 2048–56. ISSN 0270-7306. PMC 232052. PMID 9121453. 
  4. ^ Uddin, S; Chamdin A; Platanias L C (Oct 1995). "Interaction of the transcriptional activator Stat-2 with the type I interferon receptor". J. Biol. Chem. (UNITED STATES) 270 (42): 24627–30. doi:10.1074/jbc.270.42.24627. ISSN 0021-9258. PMID 7559568. 
  5. ^ Yan, H; Krishnan K; Greenlund A C; Gupta S; Lim J T; Schreiber R D; Schindler C W; Krolewski J J (Mar 1996). "Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein". EMBO J. (ENGLAND) 15 (5): 1064–74. ISSN 0261-4189. PMC 450004. PMID 8605876. 
  6. ^ Richter, M F; Duménil G; Uzé G; Fellous M; Pellegrini S (Sep 1998). "Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1". J. Biol. Chem. (UNITED STATES) 273 (38): 24723–9. doi:10.1074/jbc.273.38.24723. ISSN 0021-9258. PMID 9733772. 
  7. ^ Kumar, K G Suresh; Varghese Bentley; Banerjee Anamika; Baker Darren P; Constantinescu Stefan N; Pellegrini Sandra; Fuchs Serge Y (Jul 2008). "Basal ubiquitin-independent internalization of interferon alpha receptor is prevented by Tyk2-mediated masking of a linear endocytic motif". J. Biol. Chem. (United States) 283 (27): 18566–72. doi:10.1074/jbc.M800991200. ISSN 0021-9258. PMC 2441555. PMID 18474601. 
  8. ^ Abramovich, C; Yakobson B; Chebath J; Revel M (Jan 1997). "A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor". EMBO J. (ENGLAND) 16 (2): 260–6. doi:10.1093/emboj/16.2.260. ISSN 0261-4189. PMC 1169633. PMID 9029147. 

Further reading[edit]