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Intraflagellar transport 88
Symbols IFT88 ; D13S1056E; DAF19; TG737; TTC10; hTg737
External IDs OMIM600595 MGI98715 HomoloGene4761 GeneCards: IFT88 Gene
RNA expression pattern
PBB GE IFT88 204703 at tn.png
More reference expression data
Species Human Mouse
Entrez 8100 21821
Ensembl ENSG00000032742 ENSMUSG00000040040
UniProt Q13099 Q61371
RefSeq (mRNA) NM_006531 NM_009376
RefSeq (protein) NP_006522 NP_033402
Location (UCSC) Chr 13:
21.14 – 21.27 Mb
Chr 14:
57.42 – 57.52 Mb
PubMed search [1] [2]

Intraflagellar transport protein 88 homolog is a protein that in humans is encoded by the IFT88 gene.[1][2]


This gene encodes a member of the tetratrico peptide repeat (TPR) family. Mutations of a similar gene in mouse can cause polycystic kidney disease. Two transcript variants encoding distinct isoforms have been identified for this gene.[2] In 2012 a mutation was found to be responsible for a novel form of ciliopathy and anosmia in humans capable of remedy in mice by adenoviral mediated gene therapy.[3]


IFT88 has been shown to interact with BAT2.[4]


  1. ^ Schrick J, Onuchic L, Reeders S, Korenberg J, Chen X, Moyer J et al. (Sep 1995). "Characterization of the human homologue of the mouse Tg737 candidate polycystic kidney disease gene". Hum. Mol. Genet. 4 (4): 559–67. doi:10.1093/hmg/4.4.559. PMID 7633404. 
  2. ^ a b "Entrez Gene: IFT88 intraflagellar transport 88 homolog (Chlamydomonas)". 
  3. ^ Gene therapy rescues cilia defects and restores olfactory function in a mammalian ciliopathy model
  4. ^ Lehner B, Semple J, Brown S, Counsell D, Campbell R, Sanderson C (Jan 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819. 

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