IGF2BP3

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Insulin-like growth factor 2 mRNA binding protein 3
Protein IGF2BP3 PDB 2e44.png
PDB rendering based on 2e44.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols IGF2BP3 ; CT98; IMP-3; IMP3; KOC; KOC1; VICKZ3
External IDs OMIM608259 MGI1890359 HomoloGene4773 GeneCards: IGF2BP3 Gene
RNA expression pattern
PBB GE IGF2BP3 203820 s at tn.png
PBB GE IGF2BP3 203819 s at tn.png
PBB GE IGF2BP3 216493 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10643 140488
Ensembl ENSG00000136231 ENSMUSG00000029814
UniProt O00425 Q9CPN8
RefSeq (mRNA) NM_006547 NM_023670
RefSeq (protein) NP_006538 NP_076159
Location (UCSC) Chr 7:
23.35 – 23.51 Mb
Chr 6:
49.09 – 49.21 Mb
PubMed search [1] [2]

Insulin-like growth factor 2 mRNA-binding protein 3 is a protein that in humans is encoded by the IGF2BP3 gene.[1][2][3]

The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes.[3]

References[edit]

  1. ^ Nielsen J, Christiansen J, Lykke-Andersen J, Johnsen AH, Wewer UM, Nielsen FC (Feb 1999). "A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development". Mol Cell Biol 19 (2): 1262–70. PMC 116055. PMID 9891060. 
  2. ^ Mueller-Pillasch F, Lacher U, Wallrapp C, Micha A, Zimmerhackl F, Hameister H, Varga G, Friess H, Buchler M, Beger HG, Vila MR, Adler G, Gress TM (Jul 1997). "Cloning of a gene highly overexpressed in cancer coding for a novel KH-domain containing protein". Oncogene 14 (22): 2729–33. doi:10.1038/sj.onc.1201110. PMID 9178771. 
  3. ^ a b "Entrez Gene: IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3". 

Further reading[edit]