IGFBP1

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Insulin-like growth factor binding protein 1
Protein IGFBP1 PDB 1zt3.png
PDB rendering based on 1zt3.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols IGFBP1 ; AFBP; IBP1; IGF-BP25; PP12; hIGFBP-1
External IDs OMIM146730 MGI96436 HomoloGene498 ChEMBL: 4178 GeneCards: IGFBP1 Gene
RNA expression pattern
PBB GE IGFBP1 205302 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3484 16006
Ensembl ENSG00000146678 ENSMUSG00000020429
UniProt P08833 P47876
RefSeq (mRNA) NM_000596 NM_008341
RefSeq (protein) NP_000587 NP_032367
Location (UCSC) Chr 7:
45.93 – 45.93 Mb
Chr 11:
7.2 – 7.2 Mb
PubMed search [1] [2]

Insulin-like growth factor-binding protein 1 (IBP-1) also known as placental protein 12 (PP12) is a protein that in humans is encoded by the IGFBP1 gene.[1][2]

Function[edit]

This gene is a member of the Insulin-like growth factor-binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a type-I thyroglobulin domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[2]

References[edit]

Further reading[edit]

  • Rajaram S, Baylink DJ, Mohan S (1998). "Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions.". Endocr. Rev. 18 (6): 801–31. doi:10.1210/er.18.6.801. PMID 9408744. 
  • Ferry RJ, Cerri RW, Cohen P (1999). "Insulin-like growth factor binding proteins: new proteins, new functions.". Horm. Res. 51 (2): 53–67. doi:10.1159/000023315. PMID 10352394. 
  • Firth SM, Baxter RC (2003). "Cellular actions of the insulin-like growth factor binding proteins.". Endocr. Rev. 23 (6): 824–54. doi:10.1210/er.2001-0033. PMID 12466191. 
  • Wood AW, Duan C, Bern HA (2005). "Insulin-like growth factor signaling in fish.". Int. Rev. Cytol. 243: 215–85. doi:10.1016/S0074-7696(05)43004-1. PMID 15797461. 
  • Ehrenborg E, Larsson C, Stern I, et al. (1992). "Contiguous localization of the genes encoding human insulin-like growth factor binding proteins 1 (IGBP1) and 3 (IGBP3) on chromosome 7.". Genomics 12 (3): 497–502. doi:10.1016/0888-7543(92)90440-4. PMID 1373120. 
  • Ekstrand J, Ehrenborg E, Stern I, et al. (1990). "The gene for insulin-like growth factor-binding protein-1 is localized to human chromosomal region 7p14-p12.". Genomics 6 (3): 413–8. doi:10.1016/0888-7543(90)90470-F. PMID 1691735. 
  • Suwanichkul A, Cubbage ML, Powell DR (1991). "The promoter of the human gene for insulin-like growth factor binding protein-1. Basal promoter activity in HEP G2 cells depends upon liver factor B1.". J. Biol. Chem. 265 (34): 21185–93. PMID 1701175. 
  • Brinkman A, Kortleve DJ, Schuller AG, et al. (1991). "Site-directed mutagenesis of the N-terminal region of IGF binding protein 1; analysis of IGF binding capability.". FEBS Lett. 291 (2): 264–8. doi:10.1016/0014-5793(91)81298-M. PMID 1718783. 
  • Brewer MT, Stetler GL, Squires CH, et al. (1988). "Cloning, characterization, and expression of a human insulin-like growth factor binding protein.". Biochem. Biophys. Res. Commun. 152 (3): 1289–97. doi:10.1016/S0006-291X(88)80425-X. PMID 2454104. 
  • Julkunen M, Koistinen R, Aalto-Setälä K, et al. (1988). "Primary structure of human insulin-like growth factor-binding protein/placental protein 12 and tissue-specific expression of its mRNA.". FEBS Lett. 236 (2): 295–302. doi:10.1016/0014-5793(88)80041-3. PMID 2457513. 
  • Lee YL, Hintz RL, James PM, et al. (1988). "Insulin-like growth factor (IGF) binding protein complementary deoxyribonucleic acid from human HEP G2 hepatoma cells: predicted protein sequence suggests an IGF binding domain different from those of the IGF-I and IGF-II receptors.". Mol. Endocrinol. 2 (5): 404–11. doi:10.1210/mend-2-5-404. PMID 2458522. 
  • Luthman H, Söderling-Barros J, Persson B, et al. (1989). "Human insulin-like growth-factor-binding protein. Low-molecular-mass form: protein sequence and cDNA cloning.". Eur. J. Biochem. 180 (2): 259–65. doi:10.1111/j.1432-1033.1989.tb14641.x. PMID 2466665. 
  • Cubbage ML, Suwanichkul A, Powell DR (1989). "Structure of the human chromosomal gene for the 25 kilodalton insulin-like growth factor binding protein.". Mol. Endocrinol. 3 (5): 846–51. doi:10.1210/mend-3-5-846. PMID 2474129. 
  • Alitalo T, Kontula K, Koistinen R, et al. (1989). "The gene encoding human low-molecular weight insulin-like growth-factor binding protein (IGF-BP25): regional localization to 7p12-p13 and description of a DNA polymorphism.". Hum. Genet. 83 (4): 335–8. doi:10.1007/BF00291377. PMID 2478445. 
  • Brinkman A, Groffen CA, Kortleve DJ, Drop SL (1989). "Organization of the gene encoding the insulin-like growth factor binding protein IBP-1.". Biochem. Biophys. Res. Commun. 157 (3): 898–907. doi:10.1016/S0006-291X(88)80959-8. PMID 2849945. 
  • Busby WH, Klapper DG, Clemmons DR (1988). "Purification of a 31,000-dalton insulin-like growth factor binding protein from human amniotic fluid. Isolation of two forms with different biologic actions.". J. Biol. Chem. 263 (28): 14203–10. PMID 2971653. 
  • Grundmann U, Nerlich C, Bohn H, Rein T (1988). "Cloning of cDNA encoding human placental protein 12 (PP12): binding protein for IGF I and somatomedin.". Nucleic Acids Res. 16 (17): 8711. doi:10.1093/nar/16.17.8711. PMC 338590. PMID 3419931. 
  • Jones JI, Gockerman A, Busby WH, et al. (1993). "Insulin-like growth factor binding protein 1 stimulates cell migration and binds to the alpha 5 beta 1 integrin by means of its Arg-Gly-Asp sequence.". Proc. Natl. Acad. Sci. U.S.A. 90 (22): 10553–7. doi:10.1073/pnas.90.22.10553. PMC 47815. PMID 7504269. 
  • Jones JI, Busby WH, Wright G, et al. (1993). "Identification of the sites of phosphorylation in insulin-like growth factor binding protein-1. Regulation of its affinity by phosphorylation of serine 101.". J. Biol. Chem. 268 (2): 1125–31. PMID 7678248.