IGFBP2

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Insulin-like growth factor binding protein 2, 36kDa
Protein IGFBP2 PDB 2h7t.png
PDB rendering based on 2h7t.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols IGFBP2 ; IBP2; IGF-BP53
External IDs OMIM146731 MGI96437 HomoloGene499 ChEMBL: 3088 GeneCards: IGFBP2 Gene
RNA expression pattern
PBB GE IGFBP2 202718 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3485 16008
Ensembl ENSG00000115457 ENSMUSG00000039323
UniProt P18065 P47877
RefSeq (mRNA) NM_000597 NM_008342
RefSeq (protein) NP_000588 NP_032368
Location (UCSC) Chr 2:
217.5 – 217.53 Mb
Chr 1:
72.82 – 72.85 Mb
PubMed search [1] [2]

Insulin-like growth factor-binding protein 2 is a protein that in humans is encoded by the IGFBP2 gene.[1]


References[edit]

  1. ^ Zapf J, Kiefer M, Merryweather J, Musiarz F, Bauer D, Born W, Fischer JA, Froesch ER (Oct 1990). "Isolation from adult human serum of four insulin-like growth factor (IGF) binding proteins and molecular cloning of one of them that is increased by IGF I administration and in extrapancreatic tumor hypoglycemia". J Biol Chem 265 (25): 14892–8. PMID 1697583. 

Further reading[edit]

  • Rajaram S, Baylink DJ, Mohan S (1997). "Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions.". Endocr. Rev. 18 (6): 801–31. doi:10.1210/er.18.6.801. PMID 9408744. 
  • Wolf E, Lahm H, Wu M, et al. (2000). "Effects of IGFBP-2 overexpression in vitro and in vivo.". Pediatr. Nephrol. 14 (7): 572–8. doi:10.1007/s004670000362. PMID 10912521. 
  • Chesik D, De Keyser J, Wilczak N (2007). "Insulin-like growth factor binding protein-2 as a regulator of IGF actions in CNS: implications in multiple sclerosis.". Cytokine Growth Factor Rev. 18 (3–4): 267–78. doi:10.1016/j.cytogfr.2007.04.001. PMID 17485236. 
  • Binkert C, Margot JB, Landwehr J, et al. (1992). "Structure of the human insulin-like growth factor binding protein-2 gene". Mol. Endocrinol. 6 (5): 826–36. doi:10.1210/me.6.5.826. PMID 1376411. 
  • Zhou J, Bondy C (1992). "Insulin-like growth factor-II and its binding proteins in placental development". Endocrinology 131 (3): 1230–40. doi:10.1210/en.131.3.1230. PMID 1380437. 
  • Ehrenborg E, Vilhelmsdotter S, Bajalica S, et al. (1991). "Structure and localization of the human insulin-like growth factor-binding protein 2 gene". Biochem. Biophys. Res. Commun. 176 (3): 1250–5. doi:10.1016/0006-291X(91)90420-C. PMID 1710112. 
  • Agarwal N, Hsieh CL, Sills D, et al. (1991). "Sequence analysis, expression and chromosomal localization of a gene, isolated from a subtracted human retina cDNA library, that encodes an insulin-like growth factor binding protein (IGFBP2)". Exp. Eye Res. 52 (5): 549–61. doi:10.1016/0014-4835(91)90056-K. PMID 1712312. 
  • Roghani M, Lassarre C, Zapf J, et al. (1991). "Two insulin-like growth factor (IGF)-binding proteins are responsible for the selective affinity for IGF-II of cerebrospinal fluid binding proteins". J. Clin. Endocrinol. Metab. 73 (3): 658–66. doi:10.1210/jcem-73-3-658. PMID 1714916. 
  • Clemmons DR, Snyder DK, Busby WH (1991). "Variables controlling the secretion of insulin-like growth factor binding protein-2 in normal human subjects". J. Clin. Endocrinol. Metab. 73 (4): 727–33. doi:10.1210/jcem-73-4-727. PMID 1716260. 
  • Roghani M, Segovia B, Whitechurch O, Binoux M (1993). "Purification from human cerebrospinal fluid of insulin-like growth factor binding proteins (IGFBPs). Isolation of IGFBP-2, an altered form of IGFBP-3 and a new IGFBP species". Growth Regul. 1 (3): 125–30. PMID 1726837. 
  • Rosenfeld RG, Pham H, Conover CA, et al. (1989). "Structural and immunological comparison of insulin-like growth factor binding proteins of cerebrospinal and amniotic fluids". J. Clin. Endocrinol. Metab. 68 (3): 638–46. doi:10.1210/jcem-68-3-638. PMID 2465304. 
  • Binkert C, Landwehr J, Mary JL, et al. (1989). "Cloning, sequence analysis and expression of a cDNA encoding a novel insulin-like growth factor binding protein (IGFBP-2)". EMBO J. 8 (9): 2497–502. PMC 401241. PMID 2479552. 
  • Ilvesmäki V, Blum WF, Voutilainen R (1994). "Insulin-like growth factor binding proteins in the human adrenal gland". Mol. Cell. Endocrinol. 97 (1–2): 71–9. doi:10.1016/0303-7207(93)90212-3. PMID 7511544. 
  • Zhou J, Bondy C (1993). "Anatomy of the human ovarian insulin-like growth factor system". Biol. Reprod. 48 (3): 467–82. doi:10.1095/biolreprod48.3.467. PMID 7680905. 
  • Han VK, Bassett N, Walton J, Challis JR (1996). "The expression of insulin-like growth factor (IGF) and IGF-binding protein (IGFBP) genes in the human placenta and membranes: evidence for IGF-IGFBP interactions at the feto-maternal interface". J. Clin. Endocrinol. Metab. 81 (7): 2680–93. doi:10.1210/jc.81.7.2680. PMID 8675597. 
  • Bach LA, Rechler MM (1996). "Measurement of insulin-like growth factor (IGF)-II binding to purified IGF binding proteins 1-6: comparison of charcoal adsorption and high performance size exclusion chromatography". Biochim. Biophys. Acta 1313 (1): 79–88. doi:10.1016/0167-4889(96)00053-5. PMID 8781553. 
  • Ho PJ, Baxter RC (1997). "Insulin-like growth factor-binding protein-2 in patients with prostate carcinoma and benign prostatic hyperplasia". Clin. Endocrinol. (Oxf) 46 (3): 333–42. doi:10.1046/j.1365-2265.1997.1100922.x. PMID 9156044. 
  • Wong MS, Fong CC, Yang M (1999). "Biosensor measurement of the interaction kinetics between insulin-like growth factors and their binding proteins". Biochim. Biophys. Acta 1432 (2): 293–301. doi:10.1016/S0167-4838(99)00106-5. PMID 10407151.