IGFBP5

Insulin-like growth factor binding protein 5
PDB rendering based on 1boe.
Available structures PDB 1BOE, 1H59
Identifiers
Symbols	IGFBP5; IBP5
External IDs	OMIM: 146734 MGI: 96440 HomoloGene: 56489 GeneCards: IGFBP5 Gene
Gene Ontology Molecular function • fibronectin binding • protein binding • insulin-like growth factor I binding Cellular component • extracellular region • extracellular region • insulin-like growth factor binding protein complex Biological process • regulation of cell growth • signal transduction • regulation of glucose metabolic process • negative regulation of smooth muscle cell migration • negative regulation of translation • negative regulation of cell migration • hair follicle morphogenesis • intracellular signal transduction • glucose homeostasis • positive regulation of insulin-like growth factor receptor signaling pathway • negative regulation of insulin-like growth factor receptor signaling pathway • type B pancreatic cell proliferation • negative regulation of osteoblast differentiation • skeletal muscle tissue growth • negative regulation of smooth muscle cell proliferation • striated muscle cell differentiation • positive regulation of protein kinase B signaling cascade • mammary gland involution • cellular response to cAMP • cellular response to organic cyclic compound Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3488	16011
Ensembl	ENSG00000115461	ENSMUSG00000026185
UniProt	P24593	Q07079
RefSeq (mRNA)	NM_000599.3	NM_010518.2
RefSeq (protein)	NP_000590.1	NP_034648.2
Location (UCSC)	Chr 2: 217.54 – 217.56 Mb	Chr 1: 72.9 – 72.92 Mb
PubMed search	[1]	[2]

Insulin-like growth factor-binding protein 5 is a protein that in humans is encoded by the IGFBP5 gene.

Further reading

• Mohan S, Farley JR, Baylink DJ (1996). "Age-related changes in IGFBP-4 and IGFBP-5 levels in human serum and bone: implications for bone loss with aging.". Prog. Growth Factor Res. 6 (2–4): 465–73. doi:10.1016/0955-2235(95)00027-5. PMID 8817691. 
• Schneider MR, Wolf E, Hoeflich A, Lahm H (2002). "IGF-binding protein-5: flexible player in the IGF system and effector on its own". J. Endocrinol. 172 (3): 423–40. doi:10.1677/joe.0.1720423. PMID 11874691. 
• Firth SM, Baxter RC (2003). "Cellular actions of the insulin-like growth factor binding proteins". Endocr. Rev. 23 (6): 824–54. doi:10.1210/er.2001-0033. PMID 12466191. 
• Shimasaki S, Shimonaka M, Zhang HP, Ling N (1991). "Identification of five different insulin-like growth factor binding proteins (IGFBPs) from adult rat serum and molecular cloning of a novel IGFBP-5 in rat and human". J. Biol. Chem. 266 (16): 10646–53. PMID 1709938. 
• Ehrenborg E, Vilhelmsdotter S, Bajalica S, et al. (1991). "Structure and localization of the human insulin-like growth factor-binding protein 2 gene". Biochem. Biophys. Res. Commun. 176 (3): 1250–5. doi:10.1016/0006-291X(91)90420-C. PMID 1710112. 
• Andress DL, Birnbaum RS (1991). "A novel human insulin-like growth factor binding protein secreted by osteoblast-like cells". Biochem. Biophys. Res. Commun. 176 (1): 213–8. doi:10.1016/0006-291X(91)90911-P. PMID 1850257. 
• Kiefer MC, Ioh RS, Bauer DM, Zapf J (1991). "Molecular cloning of a new human insulin-like growth factor binding protein". Biochem. Biophys. Res. Commun. 176 (1): 219–25. doi:10.1016/0006-291X(91)90912-Q. PMID 1850258. 
• Ilvesmäki V, Blum WF, Voutilainen R (1994). "Insulin-like growth factor binding proteins in the human adrenal gland". Mol. Cell. Endocrinol. 97 (1–2): 71–9. doi:10.1016/0303-7207(93)90212-3. PMID 7511544. 
• Kou K, James PL, Clemmons DR, et al. (1994). "Identification of two clusters of mouse insulin-like growth factor binding protein genes on chromosomes 1 and 11". Genomics 21 (3): 653–5. doi:10.1006/geno.1994.1329. PMID 7525452. 
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474. 
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139146. 
• Nam TJ, Busby W, Clemmons DR (1997). "Insulin-like growth factor binding protein-5 binds to plasminogen activator inhibitor-I". Endocrinology 138 (7): 2972–8. doi:10.1210/en.138.7.2972. PMID 9202242. 
• Twigg SM, Baxter RC (1998). "Insulin-like growth factor (IGF)-binding protein 5 forms an alternative ternary complex with IGFs and the acid-labile subunit". J. Biol. Chem. 273 (11): 6074–9. doi:10.1074/jbc.273.11.6074. PMID 9497324. 
• Zheng B, Clarke JB, Busby WH, et al. (1998). "Insulin-like growth factor-binding protein-5 is cleaved by physiological concentrations of thrombin". Endocrinology 139 (4): 1708–14. doi:10.1210/en.139.4.1708. PMID 9528953. 
• Twigg SM, Kiefer MC, Zapf J, Baxter RC (1998). "Insulin-like growth factor-binding protein 5 complexes with the acid-labile subunit. Role of the carboxyl-terminal domain". J. Biol. Chem. 273 (44): 28791–8. doi:10.1074/jbc.273.44.28791. PMID 9786878. 
• Kalus W, Zweckstetter M, Renner C, et al. (1999). "Structure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5): implications for IGF and IGF-I receptor interactions". EMBO J. 17 (22): 6558–72. doi:10.1093/emboj/17.22.6558. PMC 1171003. PMID 9822601. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171003. 
• Ständker L, Wobst P, Mark S, Forssmann WG (1999). "Isolation and characterization of circulating 13-kDa C-terminal fragments of human insulin-like growth factor binding protein-5". FEBS Lett. 441 (2): 281–6. doi:10.1016/S0014-5793(98)01497-5. PMID 9883900. 
• Kecha O, Martens H, Franchimont N, et al. (1999). "Characterization of the insulin-like growth factor axis in the human thymus". J. Neuroendocrinol. 11 (6): 435–40. doi:10.1046/j.1365-2826.1999.00343.x. PMID 10336724.