IGFBP6

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Insulin-like growth factor binding protein 6
Protein IGFBP6 PDB 2jm2.png
PDB rendering based on 2jm2.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols IGFBP6 ; IBP6
External IDs OMIM146735 MGI96441 HomoloGene1641 ChEMBL: 2139 GeneCards: IGFBP6 Gene
RNA expression pattern
PBB GE IGFBP6 203851 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3489 16012
Ensembl ENSG00000167779 ENSMUSG00000023046
UniProt P24592 P47880
RefSeq (mRNA) NM_002178 NM_008344
RefSeq (protein) NP_002169 NP_032370
Location (UCSC) Chr 12:
53.49 – 53.5 Mb
Chr 15:
102.14 – 102.15 Mb
PubMed search [1] [2]

Insulin-like growth factor-binding protein 6 (IGFBP-6) is a protein that in humans is encoded by the IGFBP6 gene.[1][2][3]

References[edit]

  1. ^ Kiefer MC, Ioh RS, Bauer DM, Zapf J (May 1991). "Molecular cloning of a new human insulin-like growth factor binding protein". Biochem Biophys Res Commun 176 (1): 219–25. doi:10.1016/0006-291X(91)90912-Q. PMID 1850258. 
  2. ^ Ehrenborg E, Zazzi H, Lagercrantz S, Granqvist M, Hillerbrand U, Allander SV, Larsson C, Luthman H (May 1999). "Characterization and chromosomal localization of the human insulin-like growth factor-binding protein 6 gene". Mamm Genome 10 (4): 376–80. doi:10.1007/s003359901005. PMID 10087296. 
  3. ^ "Entrez Gene: IGFBP6 insulin-like growth factor binding protein 6". 

Further reading[edit]

  • Wood AW, Duan C, Bern HA (2005). "Insulin-like growth factor signaling in fish". Int. Rev. Cytol. International Review of Cytology 243: 215–85. doi:10.1016/S0074-7696(05)43004-1. ISBN 9780123646477. PMID 15797461. 
  • Zapf J, Kiefer M, Merryweather J, et al. (1990). "Isolation from adult human serum of four insulin-like growth factor (IGF) binding proteins and molecular cloning of one of them that is increased by IGF I administration and in extrapancreatic tumor hypoglycemia". J. Biol. Chem. 265 (25): 14892–8. PMID 1697583. 
  • Kiefer MC, Masiarz FR, Bauer DM, Zapf J (1991). "Identification and molecular cloning of two new 30-kDa insulin-like growth factor binding proteins isolated from adult human serum". J. Biol. Chem. 266 (14): 9043–9. PMID 1709161. 
  • Shimasaki S, Gao L, Shimonaka M, Ling N (1991). "Isolation and molecular cloning of insulin-like growth factor-binding protein-6". Mol. Endocrinol. 5 (7): 938–48. doi:10.1210/mend-5-7-938. PMID 1719383. 
  • Andress DL, Birnbaum RS (1991). "A novel human insulin-like growth factor binding protein secreted by osteoblast-like cells". Biochem. Biophys. Res. Commun. 176 (1): 213–8. doi:10.1016/0006-291X(91)90911-P. PMID 1850257. 
  • Martin JL, Willetts KE, Baxter RC (1990). "Purification and properties of a novel insulin-like growth factor-II binding protein from transformed human fibroblasts". J. Biol. Chem. 265 (7): 4124–30. PMID 2154495. 
  • Roghani M, Hossenlopp P, Lepage P, et al. (1989). "Isolation from human cerebrospinal fluid of a new insulin-like growth factor-binding protein with a selective affinity for IGF-II". FEBS Lett. 255 (2): 253–8. doi:10.1016/0014-5793(89)81101-9. PMID 2551732. 
  • Ilvesmäki V, Blum WF, Voutilainen R (1994). "Insulin-like growth factor binding proteins in the human adrenal gland". Mol. Cell. Endocrinol. 97 (1–2): 71–9. doi:10.1016/0303-7207(93)90212-3. PMID 7511544. 
  • Kato M, Ishizaki A, Hellman U, et al. (1995). "A human keratinocyte cell line produces two autocrine growth inhibitors, transforming growth factor-beta and insulin-like growth factor binding protein-6, in a calcium- and cell density-dependent manner". J. Biol. Chem. 270 (21): 12373–9. doi:10.1074/jbc.270.21.12373. PMID 7539002. 
  • Delhanty PJ, Hill DJ, Shimasaki S, Han VK (1993). "Insulin-like growth factor binding protein-4, -5 and -6 mRNAs in the human fetus: localization to sites of growth and differentiation?". Growth Regul. 3 (1): 8–11. PMID 7683540. 
  • Bach LA, Hsieh S, Sakano K, et al. (1993). "Binding of mutants of human insulin-like growth factor II to insulin-like growth factor binding proteins 1-6". J. Biol. Chem. 268 (13): 9246–54. PMID 7683646. 
  • Wegmann BR, Schöneberger HJ, Kiefer PE, et al. (1993). "Molecular cloning of IGFBP-5 from SCLC cell lines and expression of IGFBP-4, IGFBP-5 and IGFBP-6 in lung cancer cell lines and primary tumours". Eur. J. Cancer 29A (11): 1578–84. doi:10.1016/0959-8049(93)90298-T. PMID 7692907. 
  • Neumann GM, Marinaro JA, Bach LA (1998). "Identification of O-glycosylation sites and partial characterization of carbohydrate structure and disulfide linkages of human insulin-like growth factor binding protein 6". Biochemistry 37 (18): 6572–85. doi:10.1021/bi972894e. PMID 9572875. 
  • Neumann GM, Bach LA (1999). "The N-terminal disulfide linkages of human insulin-like growth factor-binding protein-6 (hIGFBP-6) and hIGFBP-1 are different as determined by mass spectrometry". J. Biol. Chem. 274 (21): 14587–94. doi:10.1074/jbc.274.21.14587. PMID 10329650. 
  • Wong MS, Fong CC, Yang M (1999). "Biosensor measurement of the interaction kinetics between insulin-like growth factors and their binding proteins". Biochim. Biophys. Acta 1432 (2): 293–301. doi:10.1016/S0167-4838(99)00106-5. PMID 10407151. 
  • Yu H, Mistry J, Nicar MJ, et al. (1999). "Insulin-like growth factors (IGF-I, free IGF-I and IGF-II) and insulin-like growth factor binding proteins (IGFBP-2, IGFBP-3, IGFBP-6, and ALS) in blood circulation". J. Clin. Lab. Anal. 13 (4): 166–72. doi:10.1002/(SICI)1098-2825(1999)13:4<166::AID-JCLA5>3.0.CO;2-X. PMID 10414596. 
  • Dailly YP, Zhou Y, Linkhart TA, et al. (2001). "Structure and characterization of the human insulin-like growth factor binding protein (IGFBP)-6 promoter: identification of a functional retinoid response element". Biochim. Biophys. Acta 1518 (1–2): 145–51. doi:10.1016/S0167-4781(01)00192-0. PMID 11267670. 
  • Weinzimer SA, Gibson TB, Collett-Solberg PF, et al. (2001). "Transferrin is an insulin-like growth factor-binding protein-3 binding protein". J. Clin. Endocrinol. Metab. 86 (4): 1806–13. doi:10.1210/jc.86.4.1806. PMID 11297622.