From Wikipedia, the free encyclopedia
Jump to: navigation, search
Immunoglobulin heavy constant gamma 1 (G1m marker)
Symbol IGHG1
External IDs OMIM147100 GeneCards: IGHG1 Gene
Species Human Mouse
Entrez 3500 n/a
Ensembl ENSG00000211896 n/a
UniProt P01857 n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) Chr 14:
106.2 – 106.21 Mb
PubMed search [1] n/a

Ig gamma-1 chain C region is a protein that in humans is encoded by the IGHG1 gene.[1]


Further reading[edit]

  • Ponstingl H, Hilschmann N (1977). "[The rule of antibody structure. The primary structure of a monoclonal IgG1 immunoglobulin (myeloma protein Nie). III. The chymotryptic peptides of the H-chain, alignment of the tryptic peptides and discussion of the complete structure]". Hoppe-Seyler's Z. Physiol. Chem. 357 (11): 1571–604. PMID 826475. 
  • Dreker L, Schwarz J, Reichel W, Hilschmann N (1977). "[Rule of antibody structure. the primary structure of a monoclonal IgG1 immunoglobulin (myeloma protein Nie), I: Purification and characterization of the protein, the L- and H-chains, the cyanogenbromide cleavage products, and the disulfide bridges (author's transl)]". Hoppe-Seyler's Z. Physiol. Chem. 357 (11): 1515–40. PMID 1002129. 
  • Brady RL, Edwards DJ, Hubbard RE, et al. (1992). "Crystal structure of a chimeric Fab' fragment of an antibody binding tumour cells.". J. Mol. Biol. 227 (1): 253–64. doi:10.1016/0022-2836(92)90695-G. PMID 1522589. 
  • Gall WE, Edelman GM (1971). "The covalent structure of a human gamma G-immunoglobulin. X. Intrachain disulfide bonds.". Biochemistry 9 (16): 3188–96. doi:10.1021/bi00818a011. PMID 4923144. 
  • Cunningham BA, Rutishauser U, Gall WE, et al. (1971). "The covalent structure of a human gamma G-immunoglobulin. VII. Amino acid sequence of heavy-chain cyanogen bromide fragments H1-H4.". Biochemistry 9 (16): 3161–70. doi:10.1021/bi00818a008. PMID 5489771. 
  • Rutishauser U, Cunningham BA, Bennett C, et al. (1971). "The covalent structure of a human gamma G-immunoglobulin. 8. Amino acid sequence of heavy-chain cyanogen bromide fragments H5-H7.". Biochemistry 9 (16): 3171–81. doi:10.1021/bi00818a009. PMID 5530842. 
  • Ellison JW, Berson BJ, Hood LE (1982). "The nucleotide sequence of a human immunoglobulin C gamma1 gene.". Nucleic Acids Res. 10 (13): 4071–9. doi:10.1093/nar/10.13.4071. PMC 320779. PMID 6287432. 
  • Takahashi N, Ueda S, Obata M, et al. (1982). "Structure of human immunoglobulin gamma genes: implications for evolution of a gene family.". Cell 29 (2): 671–9. doi:10.1016/0092-8674(82)90183-0. PMID 6811139. 
  • Schmidt WE, Jung HD, Palm W, Hilschmann N (1983). "[Three-dimensional structure determination of antibodies. Primary structure of crystallized monoclonal immunoglobulin IgG1 KOL, I]". Hoppe-Seyler's Z. Physiol. Chem. 364 (6): 713–47. PMID 6884994. 
  • Deisenhofer J (1981). "Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution.". Biochemistry 20 (9): 2361–70. doi:10.1021/bi00512a001. PMID 7236608. 
  • Paterson T, Innes J, McMillan L, et al. (1998). "Variation in IgG1 heavy chain allotype does not contribute to differences in biological activity of two human anti-Rhesus (D) monoclonal antibodies.". Immunotechnology 4 (1): 37–47. doi:10.1016/S1380-2933(98)00005-0. PMID 9661813. 
  • Masat L, Caldwell J, Armstrong R, et al. (2000). "Association of SWAP-70 with the B cell antigen receptor complex.". Proc. Natl. Acad. Sci. U.S.A. 97 (5): 2180–4. doi:10.1073/pnas.040374497. PMC 15774. PMID 10681448. 
  • Sondermann P, Huber R, Oosthuizen V, Jacob U (2000). "The 3.2-A crystal structure of the human IgG1 Fc fragment-Fc gammaRIII complex.". Nature 406 (6793): 267–73. doi:10.1038/35018508. PMID 10917521. 
  • Hotta K, Lange H, Tantillo DJ, et al. (2000). "Catalysis of decarboxylation by a preorganized heterogeneous microenvironment: crystal structures of abzyme 21D8.". J. Mol. Biol. 302 (5): 1213–25. doi:10.1006/jmbi.2000.4503. PMID 11183784. 
  • McLean GR, Nakouzi A, Casadevall A, Green NS (2001). "Human and murine immunoglobulin expression vector cassettes.". Mol. Immunol. 37 (14): 837–45. doi:10.1016/S0161-5890(00)00101-2. PMID 11257305. 
  • Karpusas M, Lucci J, Ferrant J, et al. (2001). "Structure of CD40 ligand in complex with the Fab fragment of a neutralizing humanized antibody.". Structure 9 (4): 321–9. doi:10.1016/S0969-2126(01)00590-1. PMID 11525169. 
  • Mimura Y, Sondermann P, Ghirlando R, et al. (2002). "Role of oligosaccharide residues of IgG1-Fc in Fc gamma RIIb binding.". J. Biol. Chem. 276 (49): 45539–47. doi:10.1074/jbc.M107478200. PMID 11567028. 
  • Pandey JP, Frederick M, (2002). "TNF-alpha, IL1-beta, and immunoglobulin (GM and KM) gene polymorphisms in sarcoidosis.". Hum. Immunol. 63 (6): 485–91. doi:10.1016/S0198-8859(02)00399-3. PMID 12039524. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.