IGSF1

Immunoglobulin superfamily, member 1
Identifiers
Symbols	IGSF1; IGCD1; IGDC1; INHBP; KIAA0364; MGC75490; PGSF2; p120
External IDs	OMIM: 300137 MGI: 2147913 HomoloGene: 1195 GeneCards: IGSF1 Gene
Gene Ontology Molecular function • receptor activity • protein binding • coreceptor activity • inhibin beta-A binding • inhibin beta-B binding Cellular component • extracellular region • membrane • integral to membrane Biological process • regulation of transcription, DNA-dependent • signal transduction Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3547	209268
Ensembl	ENSG00000147255	ENSMUSG00000031111
UniProt	Q8N6C5	n/a
RefSeq (mRNA)	NM_001170961.1	NM_177591
RefSeq (protein)	NP_001164432.1	NP_808259
Location (UCSC)	Chr X: 130.41 – 130.53 Mb	Chr X: 47.14 – 47.15 Mb
PubMed search	[1]	[2]

Immunoglobulin superfamily member 1 is a protein that in humans is encoded by the IGSF1 gene.

Members of the immunoglobulin (Ig) superfamily (see MIM 147100), which includes IGSF1, have a variety of functions, but all appear to play a role in cell recognition and the regulation of cell behavior.[supplied by OMIM]

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Nagase T, Ishikawa K, Nakajima D, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310948. 
• Chapman SC, Woodruff TK (2001). "Modulation of activin signal transduction by inhibin B and inhibin-binding protein (INhBP).". Mol. Endocrinol. 15 (4): 668–79. doi:10.1210/me.15.4.668. PMID 11266516. 
• Gui Y, Murphy LJ (2001). "Insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) binds to fibronectin (FN): demonstration of IGF-I/IGFBP-3/fn ternary complexes in human plasma.". J. Clin. Endocrinol. Metab. 86 (5): 2104–10. doi:10.1210/jc.86.5.2104. PMID 11344214. 
• Kushlinskii NE, Britvin TA, Polyakova GA, et al. (2002). "Soluble Fas antigen (sFAS) in the serum from patients with adrenal tumors.". Bull. Exp. Biol. Med. 132 (4): 990–2. doi:10.1023/A:1013683731516. PMID 11782802. 
• Tanaka S, Tatsumi K, Okubo K, et al. (2002). "Expression profile of active genes in the human pituitary gland.". J. Mol. Endocrinol. 28 (1): 33–44. doi:10.1677/jme.0.0280033. PMID 11854097. 
• Aschkenazi S, Straszewski S, Verwer KM, et al. (2003). "Differential regulation and function of the Fas/Fas ligand system in human trophoblast cells.". Biol. Reprod. 66 (6): 1853–61. doi:10.1095/biolreprod66.6.1853. PMID 12021072. 
• Nat R, Radu E, Regalia T, Popescu LM (2002). "Apoptosis in human embryo development: 3. Fas-induced apoptosis in brain primary cultures.". J. Cell. Mol. Med. 5 (4): 417–28. doi:10.1111/j.1582-4934.2001.tb00177.x. PMID 12067476. 
• Fujita T, Maruyama M, Araya J, et al. (2002). "Hydrogen peroxide induces upregulation of Fas in human airway epithelial cells via the activation of PARP-p53 pathway.". Am. J. Respir. Cell Mol. Biol. 27 (5): 542–52. PMID 12397013. 
• Albertine KH, Soulier MF, Wang Z, et al. (2002). "Fas and fas ligand are up-regulated in pulmonary edema fluid and lung tissue of patients with acute lung injury and the acute respiratory distress syndrome.". Am. J. Pathol. 161 (5): 1783–96. doi:10.1016/S0002-9440(10)64455-0. PMC 1850801. PMID 12414525. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1850801. 
• Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=187542. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Ivanov VN, Lopez Bergami P, Maulit G, et al. (2003). "FAP-1 association with Fas (Apo-1) inhibits Fas expression on the cell surface.". Mol. Cell. Biol. 23 (10): 3623–35. doi:10.1128/MCB.23.10.3623-3635.2003. PMC 164761. PMID 12724420. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=164761. 
• Bilinska M, Frydecka I, Podemski R, Gruszka E (2003). "Fas expression on T cells and sFas in relapsing-remitting multiple sclerosis.". Acta Neurol. Scand. 107 (6): 387–93. doi:10.1034/j.1600-0404.2003.00002.x. PMID 12757469. 
• Strauss G, Knape I, Melzner I, Debatin KM (2003). "Constitutive caspase activation and impaired death-inducing signaling complex formation in CD95-resistant, long-term activated, antigen-specific T cells.". J. Immunol. 171 (3): 1172–82. PMID 12874203. 
• Marsik C, Halama T, Cardona F, et al. (2004). "Regulation of Fas (APO-1, CD95) and Fas ligand expression in leukocytes during systemic inflammation in humans.". Shock 20 (6): 493–6. doi:10.1097/01.shk.0000097248.97298.ea. PMID 14625471.