IKBKE

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Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
Identifiers
Symbols IKBKE ; IKK-E; IKK-i; IKKE; IKKI
External IDs OMIM605048 MGI1929612 HomoloGene23168 ChEMBL: 3529 GeneCards: IKBKE Gene
EC number 2.7.11.10
RNA expression pattern
PBB GE IKBKE 214398 s at tn.png
PBB GE IKBKE 204549 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9641 56489
Ensembl ENSG00000143466 ENSMUSG00000042349
UniProt Q14164 Q9R0T8
RefSeq (mRNA) NM_001193321 NM_019777
RefSeq (protein) NP_001180250 NP_062751
Location (UCSC) Chr 1:
206.64 – 206.67 Mb
Chr 1:
131.25 – 131.28 Mb
PubMed search [1] [2]

Inhibitor of nuclear factor kappa-B kinase subunit epsilon also known as I-kappa-B kinase epsilon or IKK-epsilon is an enzyme that in humans is encoded by the IKBKE gene.[1][2][3]

Interactions[edit]

IKBKE has been shown to interact with TANK.[4]

Clinical significance[edit]

Inhibition of IκB kinase (IKK) and IKK-related kinases, IKBKE (IKKε) and TANK-binding kinase 1 (TBK1), has been investigated as a therapeutic option for the treatment of inflammatory diseases and cancer.[5]

References[edit]

  1. ^ Shimada T, Kawai T, Takeda K, Matsumoto M, Inoue J, Tatsumi Y, Kanamaru A, Akira S (September 1999). "IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases". Int Immunol 11 (8): 1357–62. doi:10.1093/intimm/11.8.1357. PMID 10421793. 
  2. ^ Peters RT, Liao SM, Maniatis T (July 2000). "IKKepsilon is part of a novel PMA-inducible IkappaB kinase complex". Mol Cell 5 (3): 513–22. doi:10.1016/S1097-2765(00)80445-1. PMID 10882136. 
  3. ^ "Entrez Gene: IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon". 
  4. ^ Nomura F, Kawai T, Nakanishi K, Akira S (March 2000). "NF-kappaB activation through IKK-i-dependent I-TRAF/TANK phosphorylation". Genes Cells 5 (3): 191–202. doi:10.1046/j.1365-2443.2000.00315.x. PMID 10759890. 
  5. ^ Llona-Minguez S, Baiget J, Mackay S P, (2013). "Small-molecule inhibitors of IκB kinase (IKK) and IKK-related kinases". Pharm. Pat. Anal. 2 (4): 481–498. doi:10.4155/ppa.13.31. PMID 24237125. 

Further reading[edit]