Interleukin 12 receptor, beta 2 subunit

Interleukin 12 receptor, beta 2
Identifiers
Symbols	IL12RB2; RP11-102M16.1
External IDs	OMIM: 601642 MGI: 1270861 HomoloGene: 1197 GeneCards: IL12RB2 Gene
Gene Ontology Molecular function • receptor activity • cytokine receptor activity • protein kinase binding Cellular component • integral to plasma membrane • external side of plasma membrane • membrane Biological process • cell surface receptor signaling pathway • positive regulation of cell proliferation • peptidyl-tyrosine phosphorylation • cytokine-mediated signaling pathway • response to lipopolysaccharide • positive regulation of interferon-gamma production • response to cytokine stimulus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3595	16162
Ensembl	ENSG00000081985	ENSMUSG00000018341
UniProt	Q99665	P97378
RefSeq (mRNA)	NM_001559.2	NM_008354.3
RefSeq (protein)	NP_001550.1	NP_032380.1
Location (UCSC)	Chr 1: 67.77 – 67.86 Mb	Chr 6: 67.24 – 67.33 Mb
PubMed search	[1]	[2]

Interleukin 12 receptor, beta 2 subunit is a subunit of the interleukin 12 receptor. IL12RB2 is its human gene. IL12RB2 orthologs have been identified in all mammals for which complete genome data are available.

The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense.

Interactions

Interleukin 12 receptor, beta 2 subunit has been shown to interact with Janus kinase 2.

RNA editing

The mRNA of this protein is subject to RNA editing.

Further reading

• Airoldi I, Guglielmino R, Carra G, et al. (2002). "The interleukin-12 and interleukin-12 receptor system in normal and transformed human B lymphocytes.". Haematologica 87 (4): 434–42. PMID 11940489. 
• Chua AO, Chizzonite R, Desai BB, et al. (1994). "Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130.". J. Immunol. 153 (1): 128–36. PMID 7911493. 
• Andrew SE, Goldberg YP, Kremer B, et al. (1993). "The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease.". Nat. Genet. 4 (4): 398–403. doi:10.1038/ng0893-398. PMID 8401589. 
• Presky DH, Yang H, Minetti LJ, et al. (1997). "A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits.". Proc. Natl. Acad. Sci. U.S.A. 93 (24): 14002–7. doi:10.1073/pnas.93.24.14002. PMC 19484. PMID 8943050. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=19484. 
• Zou J, Presky DH, Wu CY, Gubler U (1997). "Differential associations between the cytoplasmic regions of the interleukin-12 receptor subunits beta1 and beta2 and JAK kinases.". J. Biol. Chem. 272 (9): 6073–7. doi:10.1074/jbc.272.9.6073. PMID 9038232. 
• Rogge L, Barberis-Maino L, Biffi M, et al. (1997). "Selective expression of an interleukin-12 receptor component by human T helper 1 cells.". J. Exp. Med. 185 (5): 825–31. doi:10.1084/jem.185.5.825. PMC 2196163. PMID 9120388. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2196163. 
• Yamamoto K, Kobayashi H, Miura O, et al. (1997). "Assignment of IL12RB1 and IL12RB2, interleukin-12 receptor beta 1 and beta 2 chains, to human chromosome 19 band p13.1 and chromosome 1 band p31.2, respectively, by in situ hybridization.". Cytogenet. Cell Genet. 77 (3–4): 257–8. doi:10.1159/000134589. PMID 9284929. 
• Presky DH, Minetti LJ, Gillessen S, et al. (1998). "Analysis of the multiple interactions between IL-12 and the high affinity IL-12 receptor complex". J. Immunol. 160 (5): 2174–9. PMID 9498755. 
• Morton SM, Bocaccio I, Depetris D, et al. (1998). "Assignment of IL12RB2 to human chromosome 1p31.3→p31.2 between D1S230 and D1S198". Cytogenet. Cell Genet. 79 (3–4): 282–3. doi:10.1159/000134743. PMID 9605872. 
• Naeger LK, McKinney J, Salvekar A, Hoey T (1999). "Identification of a STAT4 binding site in the interleukin-12 receptor required for signaling". J. Biol. Chem. 274 (4): 1875–8. doi:10.1074/jbc.274.4.1875. PMID 9890938. 
• Yamamoto K, Shibata F, Miura O, et al. (1999). "Physical interaction between interleukin-12 receptor beta 2 subunit and Jak2 tyrosine kinase: Jak2 associates with cytoplasmic membrane-proximal region of interleukin-12 receptor beta 2 via amino-terminus". Biochem. Biophys. Res. Commun. 257 (2): 400–4. doi:10.1006/bbrc.1999.0479. PMID 10198225. 
• Yao BB, Niu P, Surowy CS, Faltynek CR (1999). "Direct interaction of STAT4 with the IL-12 receptor". Arch. Biochem. Biophys. 368 (1): 147–55. doi:10.1006/abbi.1999.1302. PMID 10415122. 
• Matsui E, Kaneko H, Fukao T, et al. (2000). "Mutations of the IL-12 receptor beta2 chain gene in atopic subjects". Biochem. Biophys. Res. Commun. 266 (2): 551–5. doi:10.1006/bbrc.1999.1859. PMID 10600539. 
• van Rietschoten JG, Smits HH, Westland R, et al. (2000). "Genomic organization of the human interleukin-12 receptor beta2-chain gene". Immunogenetics 51 (1): 30–6. doi:10.1007/s002510050005. PMID 10663559. 
• van Rietschoten JG, Smits HH, van de Wetering D, et al. (2001). "Silencer activity of NFATc2 in the interleukin-12 receptor beta 2 proximal promoter in human T helper cells". J. Biol. Chem. 276 (37): 34509–16. doi:10.1074/jbc.M102536200. PMID 11438525. 
• Kim J, Uyemura K, Van Dyke MK, et al. (2001). "A role for IL-12 receptor expression and signal transduction in host defense in leprosy". J. Immunol. 167 (2): 779–86. PMID 11441083. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Jones ML, Young JM, Huang QR, et al. (2003). "Interleukin 12-augmented T cell proliferation of peripheral blood mononuclear cells from HIV-seropositive individuals is associated with interleukin 12 receptor beta 2 upregulation". AIDS Res. Hum. Retroviruses 19 (4): 283–92. doi:10.1089/088922203764969483. PMID 12804004. 
• Yamamoto K, Yamaguchi M, Miyasaka N, Miura O (2003). "SOCS-3 inhibits IL-12-induced STAT4 activation by binding through its SH2 domain to the STAT4 docking site in the IL-12 receptor beta2 subunit". Biochem. Biophys. Res. Commun. 310 (4): 1188–93. doi:10.1016/j.bbrc.2003.09.140. PMID 14559241.