IL17A

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Interleukin 17A
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols IL17A ; CTLA8; IL-17; IL-17A; IL17
External IDs OMIM603149 MGI107364 HomoloGene1651 GeneCards: IL17A Gene
RNA expression pattern
PBB GE IL17A 208402 at tn.png
PBB GE IL17A 216876 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3605 16171
Ensembl ENSG00000112115 ENSMUSG00000025929
UniProt Q16552 Q62386
RefSeq (mRNA) NM_002190 NM_010552
RefSeq (protein) NP_002181 NP_034682
Location (UCSC) Chr 6:
52.05 – 52.06 Mb
Chr 1:
20.73 – 20.73 Mb
PubMed search [1] [2]

Interleukin-17A is a protein that in humans is encoded by the IL17A gene.[1][2]

The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.[2]

See also[edit]

References[edit]

  1. ^ Rouvier E, Luciani MF, Mattei MG, Denizot F, Golstein P (Jul 1993). "CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene". J Immunol 150 (12): 5445–56. PMID 8390535. 
  2. ^ a b "Entrez Gene: IL17A interleukin 17A". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.