IL17RA

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Interleukin 17 receptor A
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols IL17RA ; CANDF5; CD217; CDw217; IL-17RA; IL17R; hIL-17R
External IDs OMIM605461 MGI107399 HomoloGene7378 GeneCards: IL17RA Gene
RNA expression pattern
PBB GE IL17RA 205707 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 23765 16172
Ensembl ENSG00000177663 ENSMUSG00000002897
UniProt Q96F46 Q60943
RefSeq (mRNA) NM_014339 NM_008359
RefSeq (protein) NP_055154 NP_032385
Location (UCSC) Chr 22:
17.57 – 17.6 Mb
Chr 6:
120.46 – 120.48 Mb
PubMed search [1] [2]

Interleukin 17 receptor A, also known as IL17RA and CDw217 (cluster of differentiation w217), is a human gene.[1]

Interleukin 17A (IL17A)is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure.[1]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.