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Interleukin 17 receptor B
Symbols IL17RB ; CRL4; EVI27; IL17BR; IL17RH1
External IDs OMIM605458 MGI1355292 HomoloGene10287 IUPHAR: 1739 GeneCards: IL17RB Gene
RNA expression pattern
PBB GE IL17RB 219255 x at tn.png
More reference expression data
Species Human Mouse
Entrez 55540 50905
Ensembl ENSG00000056736 ENSMUSG00000015966
UniProt Q9NRM6 Q9JIP3
RefSeq (mRNA) NM_018725 NM_019583
RefSeq (protein) NP_061195 NP_062529
Location (UCSC) Chr 3:
53.88 – 53.9 Mb
Chr 14:
30 – 30.01 Mb
PubMed search [1] [2]

Interleukin-17 receptor B is a protein that in humans is encoded by the IL17RB gene.[1][2][3]

The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E (IL25), but does not bind to IL17(A) or IL17C. This receptor has been shown to mediate the activation of NF-κB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor.[3]

See also[edit]


  1. ^ Shi Y, Ullrich SJ, Zhang J, Connolly K, Grzegorzewski KJ, Barber MC, Wang W, Wathen K, Hodge V, Fisher CL, Olsen H, Ruben SM, Knyazev I, Cho YH, Kao V, Wilkinson KA, Carrell JA, Ebner R (Aug 2000). "A novel cytokine receptor-ligand pair. Identification, molecular characterization, and in vivo immunomodulatory activity". J Biol Chem 275 (25): 19167–76. doi:10.1074/jbc.M910228199. PMID 10749887. 
  2. ^ Tian E, Sawyer JR, Largaespada DA, Jenkins NA, Copeland NG, Shaughnessy JD Jr (Jun 2000). "Evi27 encodes a novel membrane protein with homology to the IL17 receptor". Oncogene 19 (17): 2098–109. doi:10.1038/sj.onc.1203577. PMID 10815801. 
  3. ^ a b "Entrez Gene: IL17RB interleukin 17 receptor B". 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.