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Interleukin 36 receptor antagonist
Protein IL1F5 PDB 1md6.png
PDB rendering based on 1md6.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols IL36RN ; FIL1; FIL1(DELTA); FIL1D; IL1F5; IL1HY1; IL1L1; IL1RP3; IL36RA; PSORP
External IDs OMIM605507 MGI1859325 HomoloGene10453 GeneCards: IL36RN Gene
RNA expression pattern
PBB GE IL1F5 222223 s at tn.png
More reference expression data
Species Human Mouse
Entrez 26525 54450
Ensembl ENSG00000136695 ENSMUSG00000026983
UniProt Q9UBH0 Q9QYY1
RefSeq (mRNA) NM_012275 NM_001146087
RefSeq (protein) NP_036407 NP_001139559
Location (UCSC) Chr 2:
113.82 – 113.82 Mb
Chr 2:
24.28 – 24.28 Mb
PubMed search [1] [2]

Interleukin-1 family member 5 is a protein that in humans is encoded by the IL1F5 gene.[1][2][3][4]

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding the same protein have been reported.[4]


  1. ^ Smith DE, Renshaw BR, Ketchem RR, Kubin M, Garka KE, Sims JE (Feb 2000). "Four new members expand the interleukin-1 superfamily". J Biol Chem 275 (2): 1169–75. doi:10.1074/jbc.275.2.1169. PMID 10625660. 
  2. ^ Mulero JJ, Pace AM, Nelken ST, Loeb DB, Correa TR, Drmanac R, Ford JE (Nov 1999). "IL1HY1: A novel interleukin-1 receptor antagonist gene". Biochem Biophys Res Commun 263 (3): 702–6. doi:10.1006/bbrc.1999.1440. PMID 10512743. 
  3. ^ Sims JE, Nicklin MJ, Bazan JF, Barton JL, Busfield SJ, Ford JE, Kastelein RA, Kumar S, Lin H, Mulero JJ, Pan J, Pan Y, Smith DE, Young PR (Sep 2001). "A new nomenclature for IL-1-family genes". Trends Immunol 22 (10): 536–7. doi:10.1016/S1471-4906(01)02040-3. PMID 11574262. 
  4. ^ a b "Entrez Gene: IL1F5 interleukin 1 family, member 5 (delta)". 

Further reading[edit]